Best Antiandrogen

[Rework24]

Since i now know my hair responds well to antiandrogens and grows back in without any need for a stimulant (eg minoxidil) when I get a working antiandrogen I need to know whats the best options since i can longer get flutagel and genhair 2% flutamide appears to be unstable as it does not work at all.

All suggestions welcome!!

 

[Billy-The-Kid]

I would start with Propecia (Finasteride). It worked well for me for 10 years.

I added Avodart with propecia with very good re-growth. I'm not a fan of topicals.

 

[CCS]

spironolactone. Maybe topical azelaic acid. Lavender oil. Lavender oil is not well tested though. Why not use Nizoral?

 

[zayin]

Best topical antiandrogen would be RU58841.

 

[but What about Today]

You can get MDF. Its kinda new though, so we dont know how it is.

 

[Rework24]

I would try MDF but being from England i can't get it sent over here.

I've order 6 months worth of sprio 5% to see how it compares. I had noticeable results within 3 months on flutagel and it was getting much better by 5 so 6 months on spironolactone should give me an idea if its working

 

[neis]

Rework,

Has the flutangel helped you only to maintain your hair or also to regrow? I am asking because if they were still selling it,it would be a worth addition to any regimen. I think that it's more powerful than genhair's flutamide.

 

[Rework24]

It didnt do much for my crown but my temples had re-growth and thickening. It was beautiful. Gave me loads of confidence back!

They no longer sell flutagel - i have begged and pleaded with them to make me some without joy. Genhairs stuff destroyed all the gains i had made.

I'm just hoping that my hair responds to anti androgens and that spironolactone will help.

 

[neis]

I can't understand why genhair's flutamide doesn't work as flutangel. They both have the same antiandrogen: Flutamide.

 

[Rework24]

when i contacted sinere - they said but did not conclude (for legal reasons) that genhairs formula was probably unstable

 

[Fundi]

Why did they stop making flutagel?

That must suck, good results and then unable to buy it.

 

[Bryan]

I can't understand why genhair's flutamide doesn't work as flutangel. They both have the same antiandrogen: Flutamide.

Yes, but significantly different VEHICLES. Some people think that makes a big difference.

 

[Bryan]

Why did they stop making flutagel?

I'd like to think it's because I was able to convince them that it's dangerous to use topical flutamide!

 

[Fundi]

Why did they stop making flutagel?

I'd like to think it's because I was able to convince them that it's dangerous to use topical flutamide!

How come? Is it Eurapcil (sp.) which claims it's completely side affect free? (Not that I really believe that but it's a bold claim to make)

 

[Bryan]

How come?

It could be pretty nasty to get any significant systemic absorption of flutamide. Several months ago on hairsite, I had a running conversation with a guy who was associated with the company that used to make "flutagel", and I hounded him about the relative lack of evidence for a local effect of topical flutamide, the lack of testing done by his company, and related issues. Like I said before, I'd like to think that _I_ was the one who finally made them see the light of day on selling that highly experimental stuff!

Is it Eurapcil (sp.) which claims it's completely side affect free? (Not that I really believe that but it's a bold claim to make)

Are you thinking of Eucapil (fluridil)? I won't believe ANYTHING at all about that product, until I see independent testing of it.

 

[Rework24]

Since I am sure a company would not stop a product on the say so of one person I won't rise to the bait.

But I would happily shoot you where you stood if i thought you had contributed to them discontinuing flutagel.

It was a great product.... for me anyway, like any drug being taken for something its not actually meant for people will react, but thats just tough on them! Why should the people who are not suffering the side effects and getting the benefits lose out?

Like most of the 'newer' hair loss drugs around, there is always risks and the individual should have the option to hedge his own bets!

 

[Jonathan Strange]

Since I am sure a company would not stop a product on the say so of one person I won't rise to the bait.

But I would happily shoot you where you stood if i thought you had contributed to them discontinuing flutagel.

It was a great product.... for me anyway, like any drug being taken for something its not actually meant for people will react, but thats just tough on them! Why should the people who are not suffering the side effects and getting the benefits lose out?

Like most of the 'newer' hair loss drugs around, there is always risks and the individual should have the option to hedge his own bets!

Rework,

I currently use Genhair's flutamide (at 4 months) and have seen reduced hair loss. I'm curious; how long were you on Sinere's Flutagel? How long were you on Genhair's flutamide?

BTW. It's unlikely that Bryan's handwringing motivated Sinere to take Flutagel off the market. It's far more likely that they took it off the market after receiving negative feedback from users regarding its side effects. Holster your pistol.

Other potential topical AAs:

Cyproterone acetate in an alcohol solution. CA is given in large doses to male sex offenders. Taken orally, it reduces free testosterone (by suppressing leutinizing hormone) and interferes with androgen binding to androgen receptors. Some studies have shown that topical CA reduces sebum output, which suggests that it might be effective against male pattern baldness, but I'm not aware of any studies measuring its effect on male pattern baldness directly. Not sure I'd recommend this. I've never seen reports, negative or positive, of any male pattern baldness users who have tried it.

RU58841. You're probably familiar with this one. Problems with RU include its high cost, relative unavailability (apparently a lab in China is the only current supplier), instability and consequent unreliability (some purchasers report having received "bad" batches of RU from the Chinese supplier). Another potential problem is its questionable long-term efficacy. Some long-term studies have stated that RU58841 loses effectiveness (maintenance or regression of RU-induced hair gains) after one year.

Curcumin. Might be an effective androgen receptor downregulating agent. Instead of exerting AA effects by blocking androgens from binding to the AR, like cyproterone or RU58841, curcumin actually reduces the amount of AR. Plenty of in vitro evidence, but I'm not aware of any in vivo studies. (It's only potentially effective orally for this purpose if taken with piperine, an extract of black pepper, which has been shown in at least one study to dramatically increase the bioavailability of oral curcumin in humans).

 

[Bryan]

Cyproterone acetate in an alcohol solution. CA is given in large doses to male sex offenders.

Are you sure you're not thinking of medroxyprogesterone? I don't recall ever hearing of cyproterone acetate being given to sex offenders. Maybe my memory is failing me!

Some studies have shown that topical CA reduces sebum output...

The only study I've ever seen that tested topical CA found no effect at all on sebum output.

RU58841. [...] Another potential problem is its questionable long-term efficacy. Some long-term studies have stated that RU58841 loses effectiveness (maintenance or regression of RU-induced hair gains) after one year.

As I pointed out on another site, I don't think there's even a SINGLE "study" (something published in a medical journal) that ever made such a claim. That odd statement about a "regression" with RU58841 apparently is just something written in some book, it's not something that Hideo Uno or any other researcher ever wrote about in an RU58841 study.

 

[Jonathan Strange]

Are you sure you're not thinking of medroxyprogesterone? I don't recall ever hearing of cyproterone acetate being given to sex offenders. Maybe my memory is failing me!

Both have been prescribed. CA's also been used to treat "hypersexuality" and to affect gender transformation. Pretty serious stuff!

The only study I've ever seen that tested topical CA found no effect at all on sebum output.

There are several studies indexed on pubmed showing that topical CA reduces acne lesions. Not all of these studies measured sebum levels. Here's one that did: http://www.ncbi.nlm.nih.gov/pubmed/...nel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum Perhaps the vehicle is important.

As I pointed out on another site, I don't think there's even a SINGLE "study" (something published in a medical journal) that ever made such a claim. That odd statement about a "regression" with RU58841 apparently is just something written in some book, it's not something that Hideo Uno or any other researcher ever wrote about in an RU58841 study.

It's a small world. Yeah, you replied to my post (as Chris) on HLH with the same reference to Uno (1996). I won't copy and paste my HLH reply here, but take another look at that thread if you get a chance. I'll try to clear up a few things for you here. Chang (2002), summarizing several RU studies, including Uno (1996b) and Obana, observed that early gains seen on RU treatment merely maintained or actually reversed in some cases after one year. I agree that his observations are hard to reconcile with Uno's. I'm inclined to value Chang's report over Uno's because (1) it was more recent than Uno's; (2) it's extremely unlikely that Chang misread Uno's or Obana's findings re Ru effects beyond one year -- especially since Chang actually worked with Uno AND Obana on RU58841 in 1997!! I included a reference to their joint work on RU58841 on HLH.

By the way, both Chang's (2002) and Uno's (1996) findings were published as books. Not sure why you're hung-up on format. And both are research scientists at reasonably well-regarded American universities.

 

[Jonathan Strange]

Argh! I can't get my previous message to wordwrap correctly. It looks like the right-most portion of each sentence is cut off. Can anyone tell me how to fix this?

Thanks.