Blood Test +15years On Propecia 1mg/day

[GVT]

Men 35 years:

JUNE 2015

11 years with propecia

Good density with last year increase hairloss

DHT: 353 pg/ml
Testo: 9,7 ng/ml
Testo free: 11,60 pg/ml

NOVEMBER 2019

15 year with propecia + 1 year complidermol plus 1/día (nov 18-nov 19), + shampoo pilexil 1 year 3 times/week (nov 18 - nov 19)

Less density.

DHT: 558,1 pg/dl
Testo: 11,38 ng/ml
Testo free: 19,98 pg/ml
Progesterone: 0,2 ng/ml
SHBG: 17,76 ng/ml

Las 3 years I started to do crossfit...

As you can see with 30 years I had less dht than with 35, with an increase of 40%, something quite remarkable. All this keeping the medication with Propecia of 1mg a day.

My hypotheses about why the dht may have increased:

3 years ago I have incorporated into my routine crossfit training, which increases the testo and in turn the dht.

Propecia has lost effectiveness.

The increase in testosterone caused by Propecia in turn increases dht.

Pilexil can block scalp dht and raise serum dht. I see this unlikely.

My doubts:
Still losing density in the last year, just after incorporating complidermol the itching is much lower and it seems that the fall.

 

[medSTATIC]

This is an interesting thread. I don't see how your DHT could raise so dramatically while it it supposed to decrease with age.
However male pattern baldness progresses with age because of the sensitivy of your follicles to DHT, this probably explains why for some users they see a decrease in propecia's effectiveness .
It also raises the question which has been asked many times here: does working out increase DHT to such an extent that it leads to hairloss (even if you're on propecia)?

Anyway I suggest switching to Dutasteride given your story and your long time use of Propecia

 

[badhabiz]

have you changed your diet since crossfit?
im trying to exclude the most likely explanation...which is your AA is getting stronger than the medication

yes dht is supposed to decline with age, but what concerns you is dht scalp and follice's sensivity to it...again, AA

 

[GVT]

No diet changes...

Lot of wuestions about it:

Is dht serum levels reliable? Or change at the same day?
It will be possible that our sensivity depends on dht levels? Any people say that sensivity increase with age and levels down, but perhaps sensivity is relation with total amount...
In other post I can read that hairloss depends also with ratio dht/testo, and perhaps I can find reason, because now my hairloss and itchy head decrease....

 

[Ollie]

A 40% increase could simply be due to having taken the blood test at different times of the day . Its important if you're going to compare hormone levels over time that they are taken at exactly the same time ... I.E. an hour after waking up from a nights sleep etc..

However if that isn't the problem here then it could be because your T has obviously increased between the 11 year mark and now which would explain a large part as to why DHT has increased. We dont have your SHBG levels before hand which doesn't help us understand how much of that 11 year T was bioavailable either.

 

[Feelsbadman.jpg]

Have you been taking name brand Merck the entire time or switching between generic brands?

 

[Feelsbadman.jpg]

Also, 5 alpha reductase does not decrease with age, it increases. The only reason DHT would decrease with age is due to less T which doesnt really change much between 30-35. I dont think you would see a drop in T that is significant enough to affect DHT output until middle age.

 

[Ollie]

OP having just read your results properly it’s obviously because your free T has gone up 70%. For whatever reason that may be ...

As I said though that difference may be from time of day the reading(s) took place.

 

[badhabiz]

As you've been told, no its not reliable.
I would check sexual precursors like androstenedione to get the real hormonal situation.
About the disbalance..its a theory, a fascinating one, but that ratio (which is optimal for overall wellness) is something alot of people without hair have.
What cause this sensivity? This is a good genetic question

 

[GVT]

As you've been told, no its not reliable.
I would check sexual precursors like androstenedione to get the real hormonal situation.
About the disbalance..its a theory, a fascinating one, but that ratio (which is optimal for overall wellness) is something alot of people without hair have.
What cause this sensivity? This is a good genetic question

Same moment of day, at 09:00 am. But I talk about different laboratory, same test and different results, it will be possible also?

 

[GVT]

If sensivity is genetic ok, but how can change this sensivity along life and which factors are determining it?

I have two grandparents and two cousins, one from the mother and one from the father with much less hair than me today. Also my father hair loss about 20 years.

I thought that DHT decrease with age and sensivity increase, but really is not simple.

 

[GVT]

OP having just read your results properly it’s obviously because your free T has gone up 70%. For whatever reason that may be ...

As I said though that difference may be from time of day the reading(s) took place.

Can testo free affect to DHT levels? Or only total testo?

 

[GVT]

Have you been taking name brand Merck the entire time or switching between generic brands?

9 months before first blood test I started with alocare, generic finasteride for 6 months, but my libido decrease with no time I feel with propecia, and also increase my hairloss and itchy head. I´m sure that I had a hormonal imbalance, and I change another time to propecia. Never again I feel this.

 

[badhabiz]

Same moment of day, at 09:00 am. But I talk about different laboratory, same test and different results, it will be possible also?

Yes Indeed
Thats why you should use precursors and more reliable data
You dont "change" dht sensivity thru life your genetics is programmed to be like that
Yes free testo contains a fraction of dht (along with other sexual hormones and precursors)

 

[Ollie]

Can testo free affect to DHT levels? Or only total testo?

Yes your free T is the testosterone in your blood that isn't bound to SHBG. Free test then either remains as test or it gets converted to estrogen (via aromatase) or to DHT via 5ar. As finasteride only inhibits 60-70% of your DHT production then an increase in T will mean more DHT will be created from the remaining 30% of 5ar.

 

[Feelsbadman.jpg]

9 months before first blood test I started with alocare, generic finasteride for 6 months, but my libido decrease with no time I feel with propecia, and also increase my hairloss and itchy head. I´m sure that I had a hormonal imbalance, and I change another time to propecia. Never again I feel this.

This is most likely your answer. All generics are not equal. The 10 year propecia study showed 90% retention over 10 years. 90%. They used brand name in the study. So your situation is either as unfortunate as the 10% in the study (odds are agaisnt this) or it's because the generics don't work as well.

If you are constantly changing brands, you are most likely going to have hormone fluctuations.

 

[GVT]

This is most likely your answer. All generics are not equal. The 10 year propecia study showed 90% retention over 10 years. 90%. They used brand name in the study. So your situation is either as unfortunate as the 10% in the study (odds are agaisnt this) or it's because the generics don't work as well.

If you are constantly changing brands, you are most likely going to have hormone fluctuations.

I only change one time along 15 years, and only for 6 months. Then back to Propecia...

 

[Moosey]

OP is a lying retard. Your Testosterone doesnt jump up that f*****g high because you are doing "crossfit".
Hes pinning TRT and is lying about it.
Either way even TRT doses are so marginal, im surprised finasteride allowed the DHT to almost double

 

[GVT]

[QUOTE = "Moosey, post: 1853206, miembro: 128702"] OP es un retrasado mentiroso. Su testosterona no sube esa f ***** g de altura porque está haciendo "crossfit".
Hes inmovilizando TRT y está mintiendo al respecto.
De cualquier manera, incluso las dosis de TRT son tan marginales, estoy sorprendido de que la finasterida haya permitido que el DHT casi se duplique [/ CITA]
no mate...
Nunca tomes ninguna droga, only do sport. But finasteride increase really my testo but I don't have data before take Propecia.

 

[GVT]

OP is a lying retard. Your Testosterone doesnt jump up that f*****g high because you are doing "crossfit".
Hes pinning TRT and is lying about it.
Either way even TRT doses are so marginal, im surprised finasteride allowed the DHT to almost double

Sure you are retard to propose any hypothesis. Yo know that finas down DHT and when you listen that occurs otherwise then you don´t know tp answer. Very simple knowledge...