Multiple cross sectional studies have found association between early androgenic alopecia,insulin resistance and metabolic syndrome,[SUP][62][/SUP][SUP][63][/SUP] with low HDL being the component of metabolic syndrome with highest association.[SUP][64][/SUP] Linolenic and linoleic acids, two major dietary sources of HDL, are 5 alpha reductase inhibitors.[SUP][65][/SUP] It has been suggested that premature androgenic alopecia and insulin resistance are a clinical constellation that represents the male homologue, or phenotype, of polycystic ovary syndrome.[SUP][66][/SUP] Others have found a higher rate of hyperinsulinemia in family members of women with polycystic ovarian syndrome.[SUP][67][/SUP]
In support of the association, finasteride improves glucose metabolism and decreases glycosylated hemoglobin HbA1c, a surrogate marker for diabetes mellitus.[SUP][68][/SUP] The low SHBG seen with premature androgenic alopecia is also associated with, and likely contributory to, insulin resistance,[SUP][69][/SUP] and for which it still is used as an assay for pediatric diabetes mellitus.[SUP][70][/SUP]
Obesity leads to upregulation of insulin production and decrease in SHBG. Further reinforcing the relationship, SHBG is downregulated by insulin in vitro, although SHBG levels do not appear to affect insulin production.[SUP][71][/SUP] In vivo, insulin stimulates both testosterone production and SHBG inhibition in normal and obese men.[SUP][72][/SUP] The relationship between SHBG and insulin resistance has been known for some time; decades prior, ratios of SHBG and adiponectin were used before glucose to predict insulin resistance.[SUP][73][/SUP] Patients with Laron syndrome, with resultant deficient IGF, demonstrate varying degrees of alopecia and structural defects in hair follicles when examined microscopically.[SUP][24][/SUP]
Because of its association with metabolic syndrome and altered glucose metabolism, both men and women with early androgenic hair loss should be screened for impaired glucose tolerance and diabetes mellitus II.[SUP][74][/SUP] A low fat and high fiber diet combined with regular aerobic exercise increases SHBG and insulin sensitivity.[SUP][75][/SUP] Regarding androgenic impact of diet with exercise, a study found increased protein intake led to higher concentrations of free and total testosterone immediately post exercise.[SUP][76]
http://en.wikipedia.org/wiki/Androgenic_alopecia
what are your thoughts? my dad is diabetic and i am overweight and have been for a long while [/SUP]
In support of the association, finasteride improves glucose metabolism and decreases glycosylated hemoglobin HbA1c, a surrogate marker for diabetes mellitus.[SUP][68][/SUP] The low SHBG seen with premature androgenic alopecia is also associated with, and likely contributory to, insulin resistance,[SUP][69][/SUP] and for which it still is used as an assay for pediatric diabetes mellitus.[SUP][70][/SUP]
Obesity leads to upregulation of insulin production and decrease in SHBG. Further reinforcing the relationship, SHBG is downregulated by insulin in vitro, although SHBG levels do not appear to affect insulin production.[SUP][71][/SUP] In vivo, insulin stimulates both testosterone production and SHBG inhibition in normal and obese men.[SUP][72][/SUP] The relationship between SHBG and insulin resistance has been known for some time; decades prior, ratios of SHBG and adiponectin were used before glucose to predict insulin resistance.[SUP][73][/SUP] Patients with Laron syndrome, with resultant deficient IGF, demonstrate varying degrees of alopecia and structural defects in hair follicles when examined microscopically.[SUP][24][/SUP]
Because of its association with metabolic syndrome and altered glucose metabolism, both men and women with early androgenic hair loss should be screened for impaired glucose tolerance and diabetes mellitus II.[SUP][74][/SUP] A low fat and high fiber diet combined with regular aerobic exercise increases SHBG and insulin sensitivity.[SUP][75][/SUP] Regarding androgenic impact of diet with exercise, a study found increased protein intake led to higher concentrations of free and total testosterone immediately post exercise.[SUP][76]
http://en.wikipedia.org/wiki/Androgenic_alopecia
what are your thoughts? my dad is diabetic and i am overweight and have been for a long while [/SUP]
just dont lose too much weight too fast-Sudden weight loss is a form of physical trauma that can result in thinning hair. Watch yor proteine intake-min. 60g/day