Can someone explain this about the minoxidil clinical study? (pic)
- Thread starter whatwhat
- Start date
Its not 4 months it is close to 2 years, the axis is weeks not days
I'm talking about the drop off after week 12-24
I think the important thing to note is the study ends at week 96 (treatment stopped), and the minoxidil group still retains a + 20% increase in hair weight , whereas placebo resulted in a -10 decrease ... that's a 30% swing. What happens for the first 12 to 16 weeks (+50% !) to cause it to progress so well, plateau and then drop? ... well eventually everything reaches a peak (can't progress forever), and it's perhaps not surprising that some 'negative' adjustment occurs which erases 1/2 the gain. But clearly it does help and this negative adjustment does not render minoxidil useless in the long run. Perhaps a poor analogy: often an unknown pitcher can do exceptionally well against a team for the 1st start, but once they 'understand' him things fall back to the norm. The body adjusts ... the drive by the body to maintain the equilibrium (or genetically programmed slow decline) it had before the minoxidil has to play a role here. minoxidil is not strong enough to overcome that on its own.
Parsia
Established Member
- Reaction score
- 68
Why do the results drop off a cliff after 4 months?
The reason is minoxidil just help you to get some regrowth , but at the same time the Androgens make you to be bald , thats why you need to have
Anti Androgen in your regimen , Most likely minoxidil can not help you to keep the ground , You have to attack all angels of hairloss to keep your result ( Even the regrowth you get from minoxidil ) , The trail was only on persons who use the minoxidil ..
and for long-term minoxidil alone would be fail if your hairloss related to androgens.
Sorry mate my bad. Maybe shulk is right, its the body adjusting to minoxidil.
Either way, I take it to mean 5% is not way above 2% in the longer run, except for the initial boost.
Bred Pittsburgh
Member
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- 7
Interesting that there are is not much reason in taking 5% minoxidil except a boost in the start... I guess Rogaine changed to 5% after they realized that beginning satisfaction of results improved drastically... good in terms of selling better.
"Just take 5% it is of more quality than 2% and a stronger remedy for the tough men's hair."
"Just take 5% it is of more quality than 2% and a stronger remedy for the tough men's hair."
yetti
Experienced Member
- Reaction score
- 750
Well... that's assuming that this chart is accurate. I wouldn't draw conclusions based on one 2004 chart, 1 study...
Parsia
Established Member
- Reaction score
- 68
Good Question , To be honest its a little bit hard to answer very clearly because Minoxidil studies and Propecia Studies are different and we still have lack of the study in largegroup for combination of using both , But from what I have read and my limited knowledge I would say
MOST LIKELY you will lose your hair if you are not blocking Anti Androgen , It could be vary from a person to another ,But my answer to your question is Yes , Even if minoxidil result won't drop in the 4 months I believe it would be drop in the 1-2 years as you see that
in the chart , and this is concluded from many experiences that people had before. So my suggestion is if you have male pattern baldness and it is related to your androgen you need to use it even topical or internal..If you have some side with internal AA , Try to use it topically
..Either finasteride topical or dutasteride Topical...Although the sources for topical Anti Androgen is very limited..You also have RU option as well..