can you increase absorption of minoxidil by 3-5times

[gamegammy]

by applying it to wet hair?

"Why can't I get my hair wet for four hours after using Rogaine / Can I use Rogaine after showering with my hair wet?

Wet scalp skin increases the penetration of topical drugs by several times (2x-5x more powerful). Because Rogaine does have side effects, they must attempt to keep you from increasing its potency and thereby side effects. However, if you apply Rogaine and do not experience any side effects, you might try applying it to wet scalp if you want to make it more potent. Be sure you have someone around if you do this since there is a change that you may not experience side effects on dry scalp, but may with wet scalp. If you experience side effects when applying Rogaine to dry hair, DEFINITELY *NEVER* apply it to your hair wet and be sure to follow Upjohn's instructions about not letting your hair get wet for 4 hours."

http://www.regrowth.com/hairloss-articl ... tments.cfm"

Does anybody has any knowledge about this?

 

[seneca]

Never heard this before. Always thought that applying it to damp hair would dilute the solution because of the water present and result in a loss of efficacy.

 

[franky123]

When the concentration was at 2-3%, yes this would be ok. But when you have 5% conectration with 50% pro glycol, i don't think you want to do that. Your just gonna irritate the sh*t out of your scalp.

Your welcome to try this for a few months and report back.

 

[Bryan]

Never heard this before. Always thought that applying it to damp hair would dilute the solution because of the water present and result in a loss of efficacy.

You must be fairly new around here, because people have been talking about increasing the aborption of topicals by applying to moistened skin for YEARS!

Dr. Proctor was the first one to talk about that, back on alt.baldspot. He said that applying topical drugs to moistened skin is a common "trick" among dermatologists, to increase their absorption. You have to be careful how you do it, though; you don't just use skin that's dripping wet with water, like it is immediately after showering or shampooing. You get it thoroughly wet at first, but then you dry it off till it's just a bit moist, then apply the topical. You never do it with dripping water still on your skin! :shakehead: A common piece of advice on hairloss forums is to towel-dry your hair after shampooing, then apply the topical within just a few minutes (maybe 15 minutes or so), leaving the skin still "hydrated", for absorption.

Be aware that there may still be reasons NOT to do that! Use what I just told you with care and caution!

 

[Jacob]

Dr. Lee:

"Q. Should the scalp be wet or dry when I apply the minoxidil solutions?

A. As a general rule, medications are more readily absorbed when the skin is hydrated, but pharmacodynamic studies are performed with applications to a dry skin. So the quoted statistics in regards to absorption apply to application on a dry skin. Minoxidil is not soluble in water and there is no scientific evidence to show any appreciable advantage to the application of minoxidil solutions on a hydrated scalp. Our recommendation is to apply the minoxidil solutions to a dry scalp or to the scalp that is at least towel dried in order to avoid dilution."

 

[gamegammy]

Hey guys,
I am getting severe headache I am applying minoxidil to hydrated skin. Is this the side effect related to over absorption of minoxidil?

 

[rupe]

Is it advisable to towel dry hair?

I have been avoiding this due to the damage it could do to fine hair..

 

[Xandroxuser]

Dr. Lee:

"Q. Should the scalp be wet or dry when I apply the minoxidil solutions?

A. As a general rule, medications are more readily absorbed when the skin is hydrated, but pharmacodynamic studies are performed with applications to a dry skin. So the quoted statistics in regards to absorption apply to application on a dry skin. Minoxidil is not soluble in water and there is no scientific evidence to show any appreciable advantage to the application of minoxidil solutions on a hydrated scalp. Our recommendation is to apply the minoxidil solutions to a dry scalp or to the scalp that is at least towel dried in order to avoid dilution."

Many thanks for posting this Dr Lee 'answer'. That was the great thing about Dr Lee. His supporters/followers often felt that he had a plausible/'reasonable' answer for pretty much every question which gave us great confidence to just get on and do the best we could - avoid obsessing, etc. In my experience, he was reasonable, too, in his claims. I was intrigued the other day to come across on the internet an 'answer' from him about avoiding grapefruit juice if you were taking finasteride. He argued that there was some 'scientific' evidence that made it sensible to avoid grapefruit juice if you were on finasteride. An intriguing thought - perhaps some who claim finasteride doesn't work for them have grapefruit juice for breakfast every day!

 

[WillNotLetItHappen]

I don't know about absorption but applying it to dry hair makes it look like sh*t for hours. Applying it to wet hair: 2 hrs and my hair looks nice and dry.

 

[Bryan]

Many thanks for posting this Dr Lee 'answer'. That was the great thing about Dr Lee. His supporters/followers often felt that he had a plausible/'reasonable' answer for pretty much every question which gave us great confidence to just get on and do the best we could - avoid obsessing, etc. In my experience, he was reasonable, too, in his claims.

As I explained in an earlier post in this thread, Dr. Proctor (not Dr. Lee) was the first one to talk about the issue of applying drugs to hydrated skin.

I was intrigued the other day to come across on the internet an 'answer' from him about avoiding grapefruit juice if you were taking finasteride. He argued that there was some 'scientific' evidence that made it sensible to avoid grapefruit juice if you were on finasteride. An intriguing thought - perhaps some who claim finasteride doesn't work for them have grapefruit juice for breakfast every day!

Grapefruit juice is a CYP3A4 inhibitor, which increases the absorption of drugs which would be affected by that (finasteride and dutasteride would be examples of that). I'm puzzled, though, why Dr. Lee would make such a rather odd comment like that. It might make a bit of a difference to a person who deliberately takes one of those tiny "micro-doses" of finasteride, but I don't see why anybody else would care about it. The exact amount you take of finasteride doesn't make much difference, when you're taking more significant doses.

 

[Xandroxuser]

I'm puzzled, though, why Dr. Lee would make such a rather odd comment like that. It might make a bit of a difference to a person who deliberately takes one of those tiny "micro-doses" of finasteride, but I don't see why anybody else would care about it. The exact amount you take of finasteride doesn't make much difference, when you're taking more significant doses.[/quote]


There is a Dr. Richard Lee, MD - question and answer page [an old one] where you can read responses to questions from HairLossFight.com viewers as well as post your own.

I can't open it now. And when I tried to post the link this site turns key words into ******** so I can't post the link. Sorry. I might try again another time.

 

[Bryan]

Why don't you just copy/paste what he says at that site, avoiding the obvious censorship directly? :dunno:

 

[Xandroxuser]

Why don't you just copy/paste what he says at that site, avoiding the obvious censorship directly? :dunno:

Because for some reason, I can't open it now.

This is the heading - but the censor may intervene again!

Dr. Richard Lee, MD - Hair Loss Fight

 

[Jacob]

Many thanks for posting this Dr Lee 'answer'. That was the great thing about Dr Lee. His supporters/followers often felt that he had a plausible/'reasonable' answer for pretty much every question which gave us great confidence to just get on and do the best we could - avoid obsessing, etc. In my experience, he was reasonable, too, in his claims.

As I explained in an earlier post in this thread, Dr. Proctor (not Dr. Lee) was the first one to talk about the issue of applying drugs to hydrated skin.

Oh I'm sure he was the first :shakehead: Dr Lee sure made a heck of a lot more sense..regardless.

 

[Jacob]

Why don't you just copy/paste what he says at that site, avoiding the obvious censorship directly? :dunno:

Because for some reason, I can't open it now.

This is the heading - but the censor may intervene again!

Dr. Richard Lee, MD - Hair Loss Fight

This one?

Strangely enough, yes, it can. Drinking grapefruit juice to wash down the oral doses of finasteride can raise the blood concentrations of the drug beyond what the dosage has been known to do. Unlike other citrus juices, grapefruit juice inhibits one of the body's intestinal enzyme systems and can result in marked increases in absorption of the drugs. Within the liver, the grapefruit juice competes with finasteride in its metabolic pathways and may further increase the serum levels of many prescription drugs.

Studies show that the interaction of grapefruit juice with drugs involves the compounds in grapefruit juice, called furanocoumarins (e.g. bergamottin), which block the enzymes in the intestines that normally break down many drugs, allowing more of the drug to be absorbed into the bloodstream.

In addition, grapefruit juice is one of the foods most likely to cause problems with drugs, because it is metabolized by the same enzyme in the liver that breaks down many drugs, including finasteride. The cytochrome P-450 3A4 enzyme breaks down grapefruit juice into useful components for the body, just like it breaks down dozens of medications. But, if the grapefruit juice can overload the system, keeping the liver busy and blocking it from breaking down drugs and other substances, the blood levels of the affected medication may remain too high.

Some sources recommend not ingesting grapefruit juice within 2 hours before and 5 hours after a drug, which may interact with it. Others contend that one glass of grapefruit juice could elicit the maximum blocking effect, and that the effect may persist for longer than 24 hours. Therefore, a safer approach would be to substitute another citrus juice, such as orange juice, which has the same vitamins but has not demonstrated the drug interactions.

 

[Bryan]

As I explained in an earlier post in this thread, Dr. Proctor (not Dr. Lee) was the first one to talk about the issue of applying drugs to hydrated skin.

Oh I'm sure he was the first :shakehead:

He was! You'd know that, if you'd been reading alt.baldspot for a long time. But you haven't been doing that, have you? :laugh:

 

[Jacob]

As I explained in an earlier post in this thread, Dr. Proctor (not Dr. Lee) was the first one to talk about the issue of applying drugs to hydrated skin.

Oh I'm sure he was the first :shakehead:

He was! You'd know that, if you'd been reading alt.baldspot for a long time. But you haven't been doing that, have you? :laugh:

And somebody else..not even a Doctor...probably posted something prior to him.

I wouldn't be surprised if you are still reading alt.baldspot :shock:

 

[Xandroxuser]

[Therefore, a safer approach would be to substitute another citrus juice, such as orange juice, which has the same vitamins but has not demonstrated the drug interactions.[/quote][/quote]

Thank you. Yes, that's the one. Strangely, when I went to it now, I could open it.

 

[All_The_Above]

Thank you to the original poster. I had briefly read somewhere that applying minoxidil to a wet scalp helps in absorption or the product, but I didn't realize to what degree it was until I read this post.

Is there anyone out there that has gone from applying liquid and/or foam to a dry scalp to applying it to a wet scalp? Were your results any better? I have done quite a bit of a research on the internet and I have yet to find anyone to report if they experienced positive effects from applying their minoxidil to a wet scalp.

Starting two days ago, I started applying the foam in the morning and the liquid at night to my head while it is still slightly wet. I will update on my progress in three months or so, or sooner if I notice any significant differences.


My hair continues to thin. I am currently using a combination of .5mg Dutasteride, 1 mg Finasteride, liquid monixidil, Rogaine foam and Nizoral. Nothing is working. My hair loss progresses. I have been on finasteride for 12 years, the liquid and foam for a year, and Nizoral for a couple of years now. My hair continues to go to sh*t.

I think hair loss is attached to alcohol abuse and stress more than many of us realize, because in the last year, since starting my new awful job, my stress and alcohol abuse has been through the roof, and at the same time, my hair has become significantly thinner.

I pray to God that administering the liquid and foam to a wet scalp will be my salvation.