Cnn - Cotsarelis And Christiano Interview 10/18

[hellouser]

That's what it exactly is. Christiano is insincere. It just doesn't make sense at all from a scientific standpoint. It's painful to see how hopeless this attempt is really.

I also wonder how stupid you have to be if you really genuinely believe that this is going to work and then sell your IP for JAK inhibitors to treat androgenetic alopecia that easily to a small company like Aclaris in the pharmaceutical world.

She could have just shown the world through a single case report that this works on Androgenetic Alopecia by applying a topical JAK inhibitor to someone his scalp. Brett King could have helped her with that for instance.

That way she;

- Would have become famous instantly and the hype would be insanely crazy among the whole world and field.

- Would have giants of pharmaceutical companies throwing money at her that dwarf Aclaris.

But off course she didn't do that. She just sold the rights to Aclaris easily as if a possible (near) cure to Androgenetic Alopecia would be worth nothing .

Then again she needs to get bread on the table too, and I bet you know what I mean .

And they didn't do it after YEARS of so many requests for ONE single effing case study... all of it being completely ignored. The disrespect towards Androgenetic Alopecia is unreal... even from some of the researchers. My god. No wonder I got stiffed by Dr. Christiano in Abilene!

 

[Beowulf]

Then again she needs to get bread on the table too, and I bet you know what I mean .

Dermo's don't get paid wait too much as it is in your country? Took me a month to see one because he only works two days a week and he was an hour late because he had to see a colleague's patient because he only worked one day a week.

I don't blame you guys though, in her interviews she did say that she was only interested in AA because she has it.

Someone should egg her house.

I imagine you could probably fake a clinical trial by just getting a bunch of guys to rub a little bit of acid into their temples, send them to the GP for a diagnosis, spray some bullshit into their hair and then watch their hair grow and say you did it.

 

[hidden]

I'm going to officially decide that JAK inhibitors are a complete write off. Here's why:

So the guy clearly has regular androgenic alopecia along with alopecia areata... only one alopecia was solved.

Case closed.

Cristiano and ceo of aclaris said it a zillion times that oral jak doesn't work for Androgenetic Alopecia it works only for aa so nothing newhas been discovered we will wait until results of topical bein tested are out ...

 

[InBeforeTheCure]

And they didn't do it after YEARS of so many requests for ONE single effing case study... all of it being completely ignored. The disrespect towards Androgenetic Alopecia is unreal... even from some of the researchers. My god. No wonder I got stiffed by Dr. Christiano in Abilene!

Christiano has said that she started with simple monogenic disorders -- the low-hanging fruit -- before moving on to the more complex alopetia areata:

I came to dermatology so recently that I really believed that everything about hair follicle regulation is known… so I started looking in the database and there’s nothing! Really nothing understood at all about genes that regulate hair and I sort of sat there staring at the machine and thinking that this can’t be true — this can’t be that the rest of the world is doing genetics and nobody’s doing it on hair. So rather than start our work with a big problem like androgenetic alopecia, or what I have, alopecia areata, we decided to take sort of a reductionist approach and go for a very, very simple form of inherited hair loss — where it was clearly recessively inherited so we could track how it segregated through the family as opposed to androgenetic or alopecia areata where it’s really not known how it goes through families. So for a genetics point of view we needed to find a large enough family with enough infected people to do the genetic linkage. So we started with this family in Pakistan for just that reason: because we could do the linkage and hopefully identify the gene. In contrast to the family we studied, the Pakistani family, which is a single gene defect, is that male pattern and probably alopecia areata are probably polygenic, meaning there’s more than one gene that does everything.

She got past Level 1, went up to the more difficult intermediate stage, and after some time conquered it. But is she ready to take on A.G.A., the impossibly hard, rage-inducing, final boss level? Everyone who has attempted the feat has died within seconds after the loading screen. Cotsarelis has been stuck at the very beginning of the level for decades and has trashed maybe 200 controllers in the process. And the ultimate insult is the ultra-skilled Asian gamer flying past them like it's nothing, on a speed run, when they can't even get past the first room.

 

[hellouser]

She got past Level 1, went up to the more difficult intermediate stage, and after some time conquered it. But is she ready to take on A.G.A., the impossibly hard, rage-inducing, final boss level? Everyone who has attempted the feat has died within seconds after the loading screen. Cotsarelis has been stuck at the very beginning of the level for decades and has trashed maybe 200 controllers in the process. And the ultimate insult is the ultra-skilled Asian gamer flying past them like it's nothing, on a speed run, when they can't even get past the first room.

LMAO!!!!

 

[Beowulf]

And the ultimate insult is the ultra-skilled Asian gamer flying past them like it's nothing, on a speed run, when they can't even get past the first room.

I thought the idea was the at Tsuji wasn't trying to stop baldness, but just replace what was lost? Not that I'm complaining!

 

[That Guy]

She got past Level 1, went up to the more difficult intermediate stage, and after some time conquered it. But is she ready to take on A.G.A., the impossibly hard, rage-inducing, final boss level? Everyone who has attempted the feat has died within seconds after the loading screen. Cotsarelis has been stuck at the very beginning of the level for decades and has trashed maybe 200 controllers in the process. And the ultimate insult is the ultra-skilled Asian gamer flying past them like it's nothing, on a speed run, when they can't even get past the first room.

Easily the greatest explanation of the situation.

 

[NewUser]

I thought the idea was the at Tsuji wasn't trying to stop baldness, but just replace what was lost? Not that I'm complaining!

Lo'



Even Christiano's bald mice grow more hair. lol!

 

[Beowulf]

Another problem is it doesn't look like any of the people in the photos actually got all of their hair back. But if it is indeed the case that the guy did have both AA and Androgenetic Alopecia, then it's probably the case that there aren't two forms of Androgenetic Alopecia, rather that lots of people actually have both at once.

Oh yeah and my point being that Tsuji is like one of those tool assisted runners.

 

[NewUser]

How many people do you meet in a year who are totally bald? So far I can count them on less than one finger.

So the less effective method of delivery worked to cure the 47 year-old's AA but not all of his Androgenetic Alopecia - he still gained quite a bit of hair with the glaring exception of none in his widow's peaks. Two questions:

1.How long was he performing the inferior method of ingesting Xeljanz orally?
2. And is he still taking the drug orally? Is it possible for him to grow even more hair by the inferior
delivery method?

 

[pegasus2]

JAK inhibitors wouldn't do jack for Androgenetic Alopecia by themselves, so that picture proves nothing if that guy wasn't on a DHT inhibitor. Supposedly JAK inhibitors effect on hair follicles isn't limited to immune response, but actually modulates hair follicle cycling somehow. If Christiano is wrong about that then why does it work better when applied topically? I would expect the opposite. I'm not holding my breath, but I'm still not 100% convinced that it won't work at all for Androgenetic Alopecia.

 

[champpy]

I really believe Christiano has intentionally led people to believe this might work for Androgenetic Alopecia. Then she forms a small company and sells its IP. I believe she intentionally ignored requests for a trial on any fully grown adult male with male pattern baldness so that she could get as much for her IP as possible

 

[pegasus2]

I really believe Christiano has intentionally led people to believe this might work for Androgenetic Alopecia. Then she forms a small company and sells its IP. I believe she intentionally ignored requests for a trial on any fully grown adult male with male pattern baldness so that she could get as much for her IP as possible

Most definitely. I'm sure she knows that the chances of it working on Androgenetic Alopecia are slim to none. She made sure to cash out before it was confirmed, but on the odd chance that it does work on Androgenetic Alopecia, she will profit from that too.

 

[champpy]

Most definitely. I'm sure she knows that the chances of it working on Androgenetic Alopecia are slim to none. She made sure to cash out before it was confirmed, but on the odd chance that it does work on Androgenetic Alopecia, she will profit from that too.

It shouldnt piss me off but it does. She never promised anything, but she made it seem like its possible. Just to get a company interested so they would give her money. You go girl, get your money.

All it would have taken was one researcher to apply the cream to a adult male w male pattern baldness's head. One.

Nobody would try it cause they knew it would show their hand. Cash that sh*t in quick. Im not mad at Aclaris. They are at least trying it out. That would have never happened with christiano.

Now she can go work on her Rapunzel company and fix women's hair problems, children's hair problems, dog's hair problems... everyone except men's hair problems.

 

[NewUser]

All it would have taken was one researcher to apply the cream to a adult male w male pattern baldness's head. One.

What cream? If she did develop a special topical designed to penetrate human skin, and one that will cause the drug to remain at the depth of human hair follicles for maximum effect, then Christiano must be a pathological liar when she said that it would take time and expertise to develop. She already said in an interview that mixing tofa with dmso or lanolin hand cream won't get the job done. Human skin is a lot thicker than that of Tsuji's naked mouse.

I think if Androgenetic Alopecia had a similar non-profit group as the National Alopecia Areata Foundation funding research like Christiano's, we might have had some results by now. Who's really to blame for the situation?

 

[Swoop]

Most definitely. I'm sure she knows that the chances of it working on Androgenetic Alopecia are slim to none. She made sure to cash out before it was confirmed, but on the odd chance that it does work on Androgenetic Alopecia, she will profit from that too.

+1

It shouldnt piss me off but it does. She never promised anything, but she made it seem like its possible. Just to get a company interested so they would give her money. You go girl, get your money.

All it would have taken was one researcher to apply the cream to a adult male w male pattern baldness's head. One.

Nobody would try it cause they knew it would show their hand. Cash that sh*t in quick. Im not mad at Aclaris. They are at least trying it out. That would have never happened with christiano.

Well said. FYI, this sort of stuff is very common in research nowadays.

 

[NewUser]

Well said. FYI, this sort of stuff is very common in research nowadays.

When we start slogging the handful few researchers who do actual science and have actually found a promising solution to one of several major hairloss diseases, I think it's time for a reality check.

Tha Reality check:

Contrary to the popular belief that R&D grows on trees, research and clinical trials take money and lots of it. So on that note, how much money has the National Androgenic Alopecia Foundation donated to a single starving hair biologist besides none?

NAAF's early support of Dr. Angela Christiano’s genetic studies (the first of 12 grants) in 1997, followed by the formation of the Alopecia Areata Registry, Biobank and Clinical Trials Network (Registry) in partnership with the National Institutes of Health* in 2001, proved instrumental in bringing about the groundbreaking 2010 Genome-Wide Association Study (GWAS) published in Nature.

Who should we contact to find out about an Androgenic Alopecia Registry and Biobank? Tsuji's mouse would be less naked after a few rubs of tofa or ruxo even.

 

[Beowulf]

Who should we contact to find out about an Androgenic Alopecia Registry and Biobank?

So the NAAF is just by donation and holds summits and decides how to invest the donations right? I'm sure there are people on this forum who are informed enough to tell us who to throw money at. Just invite a bunch of scientists to get drunk in your backyard and you're done!

 

[KO1]

This is why I respect Cotsarelis. He gets heat on the forums but he's our biggest voice in the research world.

 

[Swoop]

When we start slogging the handful few researchers who do actual science and have actually found a promising solution to one of several major hairloss diseases, I think it's time for a reality check.

Tha Reality check:

Contrary to the popular belief that R&D grows on trees, research and clinical trials take money and lots of it. So on that note, how much money has the National Androgenic Alopecia Foundation donated to a single starving hair biologist besides none?

Who should we contact to find out about an Androgenic Alopecia Registry and Biobank? Tsuji's mouse would be less naked after a few rubs of tofa or ruxo even.

The real reality check is that JAK inhibitors are a hopeless attempt for Androgenetic Alopecia. Like I already said I respect her as a researcher and the work she has done. Absolutely. However on the front of JAK inhibitors and Androgenetic Alopecia? It's a joke dude, from all angles.

You are so gullible. Let me give you an example.

You read this;

Though she thinks men might have the same success with an ointment, she said the trick is that it has to penetrate properly. Compared with the paper-thin skin of mice, human skin is "much thicker, and it's oily, and it's deep, and it's got a fat layer

And you parrot it immediately.... But you said that topical JAK inhibitors work for AA a few posts ago????? So tell me how do they don't penetrate properly?