"[...] we speculate that the inhibitory effect of mangifein on hSRD5A2 is due to direct inhibition of hSRD5A2 itself rather than its non-specific anti-oxidant potential. Inhibition activity of mangiferin may derive from the precipitation activity of the protein. Mangiferin possibly binds to complexes of hSRD5A2 and substrate, and this binding inhibits conversion of T to DHT. [...] There is also the possibility that other components in mangiferin can competitively or noncompetitively inhibit hSRD5A2. The finding of active component and its molecular action mechanism will be an interesting further study".