Yeah, this has gone surprisingly very smoothly and quickly for me too assuming everything checks out on confirmatory testing. If everything checks out I'll order 5 grams from Luo which in total should last me a full year. If for any reason it doesn't, I'll order a gram to test from Beryl Yang and we'll start keep going.
Either way the darolutamide train keeps running.
Just applied 2.5 mL. At 2-2.5 mL per application, that's 6-7.5 mg twice a day. Castration doses as we reviewed previously are 600 mg twice a day (due to the short half life), so even if it all goes systemic, this is still just a tiny fraction of that. If I could afford it, I'd use more. I'd love 1-2%. 1% would probably be amazingly powerful and still with likely fewer or the same side effects as finasteride/dutasteride.
Also I have to comment that this vehicle composition is very nice. I can't recommend 1,3-propanediol enough as a propylene glycol replacement. Again, anyone interested can buy it
here. Very cheap. Much smoother and silkier than propylene glycol. More soothing on the scalp. Dissolves minoxidil and other agents very well. I love it.
The 3.5% minoxidil dissolved so well in fact, I just added another 78 mg minoxidil to the remaining 15.5 mL of solution to bump it to 4%. Dissolved beautifully as well. I will keep going to see what the max minoxidil this solvent composition can handle is.
As for what you mentioned earlier about awareness for darolutamide, I think we're actually quite lucky here, and have little to worry about. Unlike RU58841, this will NOT remain an underground drug. Regardless of anything we do, unless there is some catastrophic failure in Phase III testing (highly unlikely), Bayer is bringing this to market in 3-5 years, with an intention to make hundreds of millions of dollars a year from it.
This is a superior drug to any on the market for prostate cancer and it will be huge. At that point, all the Chinese factories will be making it for $40/gram at MOST just like enzalutamide now. We will then all be able to easily afford to mix even 1% solutions.
I doubt there's anything we can do to meaningfully shift the price curve at this stage, even with more awareness. Great if more guys want to try it. I will keep posting my experience and purity results from testing. But either way, I think the big price change is going to come from Bayer and Phase III finishing above all else.
Additionally, with Replicel soon coming to market and possibly offering a way to confer actual permanent DHT resistance from injections of DHT resistant stem cells, it occurs to me we might actually be coming to an end of an era. This is the end of the era where unlucky men have to resort to swallowing castration level drugs to stop our hair loss.
In 5 years, it is actually starting to seem like things are actually going to change. I mean actually for real. Because we actually already have the technology now. It's not a fantasy anymore. It just needs to become more affordable, with longer safety data, and more mainstream.
f*****g crazy really. Pretty sure the next generation won't have any of these problems at all. The idea of taking cyproterone, spironolactone, or estrogen for hair loss will likely sound even crazier to them than it does to an average person now.
It's kind of bittersweet being on the edge of a revolution. Wish I never had to worry about any of this. As do we all I'm sure. The amount of mental and physical energy my hair loss has consumed for me is astounding. Still, better to be here, than 20 years ago when even RU wasn't available, and there was no way to learn everything we have learned. And it will be remarkable to possibly watch the end of male pattern baldness.
