Dear Lord Tsuji If You're Watching.

[Jonnyyy]

No, he is not speeding up. It's 2018 fiscal year, which ends March 2019.

So he's going to start clinical trials by march 2019? According to them?

 

[Sworthyy]

Can anyone give me a run down of what tsuji is trying to do ? Is it a glorified hair transplant or what ?

 

[Jonnyyy]

Can anyone give me a run down of what tsuji is trying to do ? Is it a glorified hair transplant or what ?

Hair transplant with unlimited donor supply, so you can gain a full head of hair again, but it's not a transplant it's an injection that I don't quite understand.

 

[g.i joey]

Only thing we got so far is a mouse with a few random hairs

werent you singing a whole different tune about rat models being oh so close to humans.. OH WAIT, only when its in your best interest of course.

 

[BaldyBalderBald]

werent you singing a whole different tune about rat models being oh so close to humans.. OH WAIT, only when its in your best interest of course.

True that, it will most likely works, and i didn't say the opposite
But that's not the point here, i'm more concern about the cosmetic finality and outcome, adjustements for density, thickness, direction of hairs to make a good product for market, this can take time.One year seems short

I want to see the actual cosmetic result of it

 

[Sworthyy]

True that, it will most likely works, and i don't say the opposite
But that's not the point here, i'm more concern about the cosmetic finality and outcome, adjustements for density, thickness, direction to make a good product for market, this can take time.One year seems short

I want to see the actual cosmetic result of it

Tell me if I'm wrong but that would at least take a decade won't it

 

[BaldyBalderBald]

Tell me if I'm wrong but that would at least take a decade won't it

I don't have a clue, but one year ? Seems unrealistic, and i hope i'm wrong just like everybody else.
I'm waiting for the first before/after pic, this day i'll celebrate

 

[Jonnyyy]

I don't have a clue, but one year ? Seems unrealistic, and i hope i'm wrong just like everybody else.
I'm waiting for the first before/after pic, this day i'll celebrate

PolarityTE thought of a product got investors went through the FDA THE FDDDDDDA and put it in market in two years, Tsuji has been doing this for twenty years, hes thought about every single scenario thousands of times in his head, and if he thinks he can get us a product out by 2020 then I'm not gonna be too much of a non believer.

 

[Keisi92]

It seems I understand Tsuji way less than I actually thought. I should read these forums more carefully. I always thought that he would fully clone hairs outside, than transfer them to our heads. As in a transplant just that he would have an army of cloned hairs to put back in our heads.

I would quote baldybalderbald on the cosmetic results.I would say that thickness of hair shouldn't be a problem considering that it would be a clone of an existing healthy hair. If he at least resolves the density problem it would still be a solution to some people. Doesn't matter much which direction your hair grows if you cut them really short as in 5mm or lower so it wouldn't really be noticable.

Direction though would be a real problem. I can't imagine how bad it would be if you have hair growing in all kind of directions.

 

[Jonnyyy]

It seems I understand Tsuji way less than I actually thought. I should read these forums more carefully. I always thought that he would fully clone hairs outside, than transfer them to our heads. As in a transplant just that he would have an army of cloned hairs to put back in our heads.

I would quote baldybalderbald on the cosmetic results.I would say that thickness of hair shouldn't be a problem considering that it would be a clone of an existing healthy hair. If he at least resolves the density problem it would still be a solution to some people. Doesn't matter much which direction your hair grows if you cut them really short as in 5mm or lower so it wouldn't really be noticable.

Direction though would be a real problem. I can't imagine how bad it would be if you have hair growing in all kind of directions.

I don't think Tsuji would release a product in this state, he's spent too much time doing this to make a mediocre product, they've got a huge team with all the money in the world, I'm sure they're going through every single scenario out there and solving it as best as they can until they can do it hands on in clinical trials.

 

[BaldyBalderBald]

PolarityTE thought of a product got investors went through the FDA THE FDDDDDDA and put it in market in two years, Tsuji has been doing this for twenty years, hes thought about every single scenario thousands of times in his head, and if he thinks he can get us a product out by 2020 then I'm not gonna be too much of a non believer.

PolarityTE ? Nothing relevant for us so far, it's for burned skin, not for Androgenetic Alopecia, even if it works completely, you will loose hair again after your all scalp skin removed and regenerated by their product.They are not "growing" your skin in a lab here, i suggest your read their patent.
No results for density, thickness or whatsoever by now.They mention hair follicles during skin regeneration because all of our skin have hair follicles, arms, legs...this is what makes a skin actually functional.During scarring process or burn wound, skin looses hair follicles and fibroblasts.
Scarless process is fully functionnal by regenerating these hair follciles aswell, i'll wait until PolarityTE actually say something about Androgenetic Alopecia, as of today, that's not the case.

And btw Mr.FDDDAAAA i was aware of PolarityTE before you even came to this forum.

It seems I understand Tsuji way less than I actually thought. I should read these forums more carefully. I always thought that he would fully clone hairs outside, than transfer them to our heads. As in a transplant just that he would have an army of cloned hairs to put back in our heads.

I would quote baldybalderbald on the cosmetic results.I would say that thickness of hair shouldn't be a problem considering that it would be a clone of an existing healthy hair. If he at least resolves the density problem it would still be a solution to some people. Doesn't matter much which direction your hair grows if you cut them really short as in 5mm or lower so it wouldn't really be noticable.

Direction though would be a real problem. I can't imagine how bad it would be if you have hair growing in all kind of directions.

That's pretty much my concern about their timeline, this is not a regular hair transplant.

"The treatment involves extracting a small number of hair follicles from a person’s donor scalp area and then isolating two specific types of cells from the follicle – papilla cells and epidermal cells from the bulge region. These cells are then cultured, expanded, and combined to create a hair follicle “germ” or “follicular primordium.” Once the hair follicle germs are ready they are transported to a facility where they can be implanted back into a person’s scalp to grow hair." - Quote from FollicleThought (yes i know...), but that's pretty much a good and simplified abstract.

So after the papilla cells and epidermal cells are turn into follicular primordium they will "transplant" it back to the scalp and wait for growth to see the first human result.Considering the actual rate of growth of human hair, and the fact that in Japan clinical trials take place in two phases, i don't know if they can pull it off in one single year but again i might be wrong.Density was never noticed in any of their results in mice, they just test it succesfully in 2016.And they think they can resolve the direction problem with strings or things like that, don't quote me on this i'm not sure.That's a lot of work in one single year, even if everything goes well.

I don't know if it's even possible to do 2 clinical trial phases in one year anyway with all the governement paperwork and regulations.

As for the hair direction with a buzzcut @Keisi92, to me, that's where your hair direction is the most noticeable, especially in temples, but i agree, this is a secondary aspect, density and thickness are way more important for advanced hair loss.

Anyway, only time will tell, that's just seems a huge amount of work, even for a research institute like Riken, but i'm talking to hope fanatics here.

 

[Jonnyyy]

PolarityTE ? Nothing relevant for us so far, it's for burned skin, not for Androgenetic Alopecia, even if it works completely, you will loose hair again after your all scalp skin removed and regenerated by their product.They are not "growing" your skin in a lab here, i suggest your read their patent.
No results for density, thickness or whatsoever by now.They mention hair follicles during skin regeneration because all of our skin have hair follicles, arms, legs...this is what makes a skin actually functional.During scarring process or burn wound, skin looses hair follicles and fibroblasts.
Scarless process is fully functionnal by regenerating these hair follciles aswell, i'll wait until PolarityTE actually say something about Androgenetic Alopecia, as of today, that's not the case.

And btw Mr.FDDDAAAA i was aware of PolarityTE before you even came to this forum.



That's pretty much my concern about their timeline, this is not a regular hair transplant.

"The treatment involves extracting a small number of hair follicles from a person’s donor scalp area and then isolating two specific types of cells from the follicle – papilla cells and epidermal cells from the bulge region. These cells are then cultured, expanded, and combined to create a hair follicle “germ” or “follicular primordium.” Once the hair follicle germs are ready they are transported to a facility where they can be implanted back into a person’s scalp to grow hair." - Quote from FollicleThought (yes i know...), but that's pretty much a good and simplified abstract.

So after the papilla cells and epidermal cells are turn into follicular primordium they will "transplant" it back to the scalp and wait for growth to see the first human result.Considering the actual rate of growth of human hair, and the fact that in Japan clinical trials take place in two phases, i don't know if they can pull it off in one single year but again i might be wrong.Density was never noticed in any of their results in mice, they just test it succesfully in 2016.And they think they can resolve the direction problem with strings or things like that, don't quote me on this i'm not sure.That's a lot of work in one single year, even if everything goes well.

I don't know if it's even possible to do 2 clinical trial phases in one year anyway with all the governement paperwork and regulations.

As for the hair direction with a buzzcut @Keisi92, to me, that's where your hair direction is the most noticeable, especially in temples, but i agree, this is a secondary aspect, density and thickness are way more important for advanced hair loss.

Anyway, only time will tell, that's just seems a huge amount of work, even for a research institute like Riken, but i'm talking to hope fanatics here.

View attachment 67457

Hope fanatics? Lmfao if you've seen my regular posts I bash on Brotzu, Replicel, Histogen all of them, because time and time again they fail to deliver or just don't give updates for the obvious reasons that their product is nowhere close to ready, Tsuji is updating people emailing them about his progress, telling him his next barrier then breaking that barrier a few months later, like I said I could be wrong but I don't see him not being able to have this commercialized by 2020, it might be limited but it will be out and if I'm wrong then we will be shiny cue balls for life.

 

[BaldyBalderBald]

Hope fanatics? Lmfao if you've seen my regular posts I bash on Brotzu, Replicel, Histogen all of them, because time and time again they fail to deliver or just don't give updates for the obvious reasons that their product is nowhere close to ready, Tsuji is updating people emailing them about his progress, telling him his next barrier then breaking that barrier a few months later, like I said I could be wrong but I don't see him not being able to have this commercialized by 2020, it might be limited but it will be out and if I'm wrong then we will be shiny cue balls for life.

I hope they will make it by 2020 man

 

[Jonnyyy]

I hope they will make it by 2020 man

Imagine if it's like aderans and that other sh*t company, we'd be fucked til like 2030.

 

[BaldyBalderBald]

Imagine if it's like aderans and that other sh*t company, we'd be fucked til like 2030.

Actually i'm not that pessimistic, I thought about 2021-2022 max considering the working proof of concept of their tech, no one had succeded so far, they are way ahead that's for sure.It's just that 2020 with one year of human trials, well that's utterly optimistic

 

[Jonnyyy]

Actually i'm not that pessimistic, I thought about 2021-2022 max considering the working proof of concept of their tech, no one had succeded so far, they are way ahead that's for sure.It's just that 2020 with one year of human trials, well that's utterly optimistic

I agree with you but at the same time I wouldn't doubt them too much they seem like they've got everything down (obvious other than if it works on humans or not lol)

 

[H]

It seems I understand Tsuji way less than I actually thought. I should read these forums more carefully. I always thought that he would fully clone hairs outside, than transfer them to our heads. As in a transplant just that he would have an army of cloned hairs to put back in our heads.

I would quote baldybalderbald on the cosmetic results.I would say that thickness of hair shouldn't be a problem considering that it would be a clone of an existing healthy hair. If he at least resolves the density problem it would still be a solution to some people. Doesn't matter much which direction your hair grows if you cut them really short as in 5mm or lower so it wouldn't really be noticable.

Direction though would be a real problem. I can't imagine how bad it would be if you have hair growing in all kind of directions.

That direction concern is in the actual interview I believe and the conscencus at least from what I've seen is that the surround tissue actually determines most of the direction so your hair I assume (I don't actually know for sure but from what I've read this is what it seems to me to be) the hairs will take on the natural shape your original hair took based on your scalp configuration.

 

[BaldyBalderBald]

That direction concern is in the actual interview I believe and the conscencus at least from what I've seen is that the surround tissue actually determines most of the direction so your hair I assume (I don't actually know for sure but from what I've read this is what it seems to me to be) the hairs will take on the natural shape your original hair took based on your scalp configuration.

You got the source of the interview ? Are you talking about PCP (Planar cell polarity) ? I don't know if that applies here, it's involved during wound healing tho, but if you got the source i'm interested

Patterning skin by planar cell polarity: the multi-talented hair designer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257556/

 

[H]

You got the source of the interview ?

"Keiko: Thank you. Question 7: On the topic of aesthetics: Do you think the direction of hair growth be controlled by natural processes in the skin, or will the placement and positioning of the primordium cells by a qualified surgeon cells play a role? There was previous mention of using a “Nylon Thread Guide” for controlling hair-growth direction, and to limit epithelial cyst formation. Is this still the current plan?

Mr. Toyoshima: This hair-growth direction, which is the flow of hair, is determined when hair is generated. For our published paper, we create a small incision using a small surgical knife, which, as I mentioned earlier, is in the same direction as the hair flow. When the hair follicle germ is grafted in this incision, all hair was regenerated in the same direction as the original hair flow. On the other hand, as an experiment, we also created a small incision for grafting in the opposite direction. This was an experiment using body hair. It is known that the connection direction of arrector pili muscles of hair completely align with hair flow. The results determined that the connection direction of the arrector muscles of hair, as well hair flow, was actually influenced by the surrounding tissues.

Keiko: So this is what you mentioned earlier that transplanted follicles interact with the surrounding tissues…

Mr. Toyoshima: Yes, we believe this can happen. This is dependent on types of hair, the condition of skin for transplant, etc., therefore although we cannot say that it will definitely happen, we think that the direction of regenerated hair growth will align with that of the original hair. For this, we plan to develop a clinical model in the clinical research in the future in order to further study this point. As for the “Nylon Thread Guide”, the most important objective of using it is to prevent a formation of epithelial cyst. As far as the determination of hair growth, it is used to determine the direction of connection with epidermal direction. Transplanted hair follicle germ should not form a cyst, under the skin, therefore in order to prevent such case, we need to make sure that the epidermal layer is firmly attached to the epidermal layer of the transplanted regenerated hair follicle germ. Nylon thread guide is used to ensure this. Therefore, we will probably have to use it in clinical application, and its use is expected to prevent such abnormal results. So we think it is reasonable to use it."
This site is the source.

 

[BaldyBalderBald]

"Keiko: Thank you. Question 7: On the topic of aesthetics: Do you think the direction of hair growth be controlled by natural processes in the skin, or will the placement and positioning of the primordium cells by a qualified surgeon cells play a role? There was previous mention of using a “Nylon Thread Guide” for controlling hair-growth direction, and to limit epithelial cyst formation. Is this still the current plan?

Mr. Toyoshima: This hair-growth direction, which is the flow of hair, is determined when hair is generated. For our published paper, we create a small incision using a small surgical knife, which, as I mentioned earlier, is in the same direction as the hair flow. When the hair follicle germ is grafted in this incision, all hair was regenerated in the same direction as the original hair flow. On the other hand, as an experiment, we also created a small incision for grafting in the opposite direction. This was an experiment using body hair. It is known that the connection direction of arrector pili muscles of hair completely align with hair flow. The results determined that the connection direction of the arrector muscles of hair, as well hair flow, was actually influenced by the surrounding tissues.

Keiko: So this is what you mentioned earlier that transplanted follicles interact with the surrounding tissues…

Mr. Toyoshima: Yes, we believe this can happen. This is dependent on types of hair, the condition of skin for transplant, etc., therefore although we cannot say that it will definitely happen, we think that the direction of regenerated hair growth will align with that of the original hair. For this, we plan to develop a clinical model in the clinical research in the future in order to further study this point. As for the “Nylon Thread Guide”, the most important objective of using it is to prevent a formation of epithelial cyst. As far as the determination of hair growth, it is used to determine the direction of connection with epidermal direction. Transplanted hair follicle germ should not form a cyst, under the skin, therefore in order to prevent such case, we need to make sure that the epidermal layer is firmly attached to the epidermal layer of the transplanted regenerated hair follicle germ. Nylon thread guide is used to ensure this. Therefore, we will probably have to use it in clinical application, and its use is expected to prevent such abnormal results. So we think it is reasonable to use it."
This site is the source.

Nice, thx
Sounds like meticulous work here this Nylon thread guide