DHT inhibitors (dutasteride/finasteride) cause premature aging (?)

Mindfull

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I CANNOT back this up scientifically. Im only suggesting the obvious while concluding that there in fact has not been any long term studies of what effect long term systemic supression of dht has on the aging body. Common sense would suggest that any altering of testoterone levels of this magnitude will affect your body in many, perhaps subtle, ways over the years. Short term clinical studies most likely will not be able to uncover such gradual changes or accelerated degeneration. Perhaps your skin just wrinkles a litle more and faster as you become more vulnerable to the attack of free radicals, or perhaps dna is more easily oxidized and the notorious damage from bad diet, lifestyle, toxins, pollution, radiation and other stuff is accelerated if your homone balance is not intact.

Nowadays hormones are introduced to repair socalled telomeres on the dna. You may say that this has nothing to do wiht dht supression, but its known that testosterone does play a role in aiding genetic repair and telomerase and thus, in theory, any altering of testosterone levels could also potentially affect telomerase. I obviously cant know.

As we age the secretion of many hormones declines and their effectiveness (compared unit to unit) is also reduced due to the receptors down-grading. Again, thats why growth hormone has been put forward as a potential age defiant (although clinical studies show no clear benefit in this regard). If we´re left with more testoterone circulating in your bodies, some of this will be converted into oestrogen even if it does not result in any experienced side effects. I just wonder how this affects the ageing process when you also consider that hypothalamus, as we grow older, looses its precision and regulatory abillity and that the receptors which uptake individual hormones become less sensitive to them.

I searched for relevant keywords on pubmed, but dit not find any studies. Im only suggesting the common sense: Your hormones are in your body for a very good reason.
 

Mindfull

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I will look into this further, and I will contact some biogerontologists for some qualified 'speculation' ... since if there was any clear 'yes' or 'no' to the question of whether dht inhibition can cause premature aging, then surely it would be written all over. But I think everybody deserves to be informed even about the theoretical perspectives in this matter. I will keep you updated and I welcome any personal experiences or qualified feedback on the subject.

Thanks
 

mvpsoft

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I asked Loren Pickart whether dutasteride has any negative effect on the skin, and he did not know. He is a research scientist that has been studying skin aging and remodeling for over 40 years. So I doubt that there is any research on this issue. All he told me is that it's better to stay away from messing with hormones because we don't know what unintended effects it may have. Well, I know that, but it doesn't answer the specific question.
 

Mindfull

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mvpsoft said:
I asked Loren Pickart whether dutasteride has any negative effect on the skin, and he did not know. He is a research scientist that has been studying skin aging and remodeling for over 40 years. So I doubt that there is any research on this issue. All he told me is that it's better to stay away from messing with hormones because we don't know what unintended effects it may have. Well, I know that, but it doesn't answer the specific question.

Of course no specialist can say anything for sure based on no clinical studies. However, I´d like to hear several oppinions, even if they are just speculations, since such speculations most likely express some sort of possibility of one thing or the other. Clinical studies are costly and long term studies take... time. Hypothesis´s are for free, but if 4 out of 6 specialists (I would prefer if they are biochemistrists or alike specializing in aging ) say that inhibiting dht could possibly accelerate aging, then Im probably going to get off these pills right away. Remember that Propecia works the same way, although finasteride only inhibits type AR-2 isozyme while dutasteride inhibits both type 1 and 2 of the AR isozymes that convert testosterone into DHT.

Ill keep you informed, thanks
 

Karmaz

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I think there's way to much worrying about how finasteride might mess you up in the long term.

Women have taken the contraceptive pill for many years, with no negative effects.
 

Mindfull

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Bismarck said:
dutasteride has an effect on the skin, it reduces sebum production.

And finasteride does not? As far as Ive heard, finasteride only works on the follicles, and not the skin ... ?
Perhaps that is why Avodart dryed out my skin and added wrinkles to my face in just 2 months....
 

Bismarck

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Mindfull said:
Bismarck said:
dutasteride has an effect on the skin, it reduces sebum production.

And finasteride does not? As far as Ive heard, finasteride only works on the follicles, and not the skin ... ?
Perhaps that is why Avodart dryed out my skin and added wrinkles to my face in just 2 months....

dutasteride inhibits 5aR type I and type II. finasteride only inhibits type II.
Type I is found in the sebaceous glands in the skin (these small organs produce sebum). That's why people experience dry skin on dutasteride but not on finasteride.


bis
 

Mindfull

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curiously enough the guy(s) in the link above experienced increased sebaceous oil gland production ... thats odd
 

otis

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DHT is bad . it is bad for your prostate gland and your hair.Getting rid of it is very good for you.
 
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