baldeagle said:Scoiland, Its the Minoxidil. I had this face puffiness a few days back. The puffiness went away when I dropped Minoxidil for a few days. Did you apply Minoxidil over your wet scalp? Applying on a wet scalp results in excessive systemic absorption( a lot of Minoxidil is absorbed in the blood stream) and hence the face puffiness.