Does minoxidil slow down hair loss?

finalflare

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I know it helps regrow hair but will it help slow down hair loss? I've been using it on my hairline but with the intention to slow down hair loss... I really don't care about regrowth...
 

cthulhu2.0

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Yes it will, but it will start to lose efficacy after the 1 year mark. Finasteride is def better for slowing down/preserving
 

cthulhu2.0

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[h=1]Five-year follow-up of men with androgenetic alopecia treated with topical minoxidil.[/h]Olsen EA1, Weiner MS, Amara IA, DeLong ER.
[h=3]Author information[/h]

[h=3]Abstract[/h]Thirty-one men with androgenetic alopecia completed 4 1/2 to 5 years of therapy with 2% and 3% topical minoxidil. Hair regrowth with topical minoxidil tended to peak at 1 year with a slow decline in regrowth over subsequent years. However, at 4 1/2 to 5 years, maintenance of nonvellus hairs beyond that seen at baseline was still evident. Topical minoxidil appears to be effective in helping to maintain nonvellus hair growth in men with androgenetic alopecia.




 

finalflare

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Five-year follow-up of men with androgenetic alopecia treated with topical minoxidil.

Olsen EA1, Weiner MS, Amara IA, DeLong ER.
Author information



Abstract

Thirty-one men with androgenetic alopecia completed 4 1/2 to 5 years of therapy with 2% and 3% topical minoxidil. Hair regrowth with topical minoxidil tended to peak at 1 year with a slow decline in regrowth over subsequent years. However, at 4 1/2 to 5 years, maintenance of nonvellus hairs beyond that seen at baseline was still evident. Topical minoxidil appears to be effective in helping to maintain nonvellus hair growth in men with androgenetic alopecia.



thanks man! Hmm I really wonder how minoxidil does that as it doesn't do anything to dht
 

finalflare

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Five-year follow-up of men with androgenetic alopecia treated with topical minoxidil.

Olsen EA1, Weiner MS, Amara IA, DeLong ER.
Author information



Abstract

Thirty-one men with androgenetic alopecia completed 4 1/2 to 5 years of therapy with 2% and 3% topical minoxidil. Hair regrowth with topical minoxidil tended to peak at 1 year with a slow decline in regrowth over subsequent years. However, at 4 1/2 to 5 years, maintenance of nonvellus hairs beyond that seen at baseline was still evident. Topical minoxidil appears to be effective in helping to maintain nonvellus hair growth in men with androgenetic alopecia.



thank you! I'm really curious of how minoxidil does that as it doesn't do anything to dht
 

WarLord

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Yes it will, but it will start to lose efficacy after the 1 year mark. Finasteride is def better for slowing down/preserving

This is not true! Please, stop spreading this misinformation. In the longest study that has been done on the efficiacy of minoxidil (Olsen et al., 1990: Five-year follow-up of men with androgenetic alopecia treated with topical minoxidil), 31 patients, who remained in the study were still above baseline after 5 years (on average). But there were large individual differences. Some were gradually losing their hair, but about a third were still REGROWING hair after 5 years. (Now I noticed that a collegue had already listed it above :)

Some clueless people see 1-2 years' studies, in which the number of hairs starts to decrease after 1 year, and they conclude that "minoxidil will start to lose efficiacy after 1 year". Don't you remember finasteride studies, in which the number of hairs also decreases after 2 years? This is due to the fact that anti-hairloss drugs stimulate a lot of hairs at once and with the passing time, the cycles of these hairs will desynchronize. This will lead to the decrease of density, but not necessarily to the overall worsening, because the quality (thickness) of hair shafts will increase.

The effect of minoxidil is dose-dependent, which means that the statement "minoxidil will lose its efficiacy" is simply nonsensical. If the dosage is not enough, you must simply increase it. For some people, the 5% concentration is too weak in the long run. But there are others, who have been using 5% minoxidil for 20+ years.
http://www.hairlosshelp.com/forums/...d=90004&STARTPAGE=2&FTVAR_FORUMVIEWTMP=Linear

I was using 2-5% minoxidil alone for 15,5 years and if I didn't start to make experiments with some hormonal drugs, I believe that it would work on its own until now. But today, I must already combine it with dutasteride.
 

cthulhu2.0

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Yes, there were some people who had increasing growth after 5 years but there were also some minoxidil users that had hair below baseline. However, the general trend was that minoxidil slowly loses effectiveness after 1 year for the majority of patient's in the trial. Of course, in every study there will be outliers. Can you point me to the study that finasteride causes the "number of hairs also decreases after 2 years". The long term studies on finasteride that I have read show finasteride to be more effective in the long term for those who who responded well to finasteride initially.
 

WarLord

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However, the general trend was that minoxidil slowly loses effectiveness after 1 year for the majority of patient's in the trial.

This is inevitable. Even if 90% patients were stable and only 10% were losing hair, the AVERAGE HAIR COUNTS would decline. People often misinterpret the graphs in the way that when the average hair counts decline, then they decline in 100% men in the study. Apparently, this is not true. There is a very large variability. Furthermore, 3% minoxidil must be very weak for lots of men. I was actually lucky that 2% minoxidil worked for me for 11,5 years. No regrowth, but it kept the hairline without any change.

As for the declining hair counts in men using finasteride, it has been documented in every 5-year study.
https://encrypted-tbn3.gstatic.com/...zARRrHJmmFK2D493v2-XtkrvzWZlfSldpkAEQbiNhocBw
http://images.ddccdn.com/pro/images/c32453b1-1683-4fe8-bbf5-dba927966729/propecia-02.jpg

But as I said, it doesn't mean that it stopped working. Initially, the drug simply stimulates a regrowth of many thin hairs, but they gradually become stronger and their cycles desynchronize.
 
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