Dutasteride And Letrozole Together, Gynecomastia Side

[nicksparrow]

I'm a 24y.o male. Have a receding hairline and thinning at crown.
I noticed my hair thinning and receding since about 6 months ago.
I tried dutasteride, but by the 8th pill i noticed my breasts have enlarged(mild gynecomastia).
I'm taking letrozole now to reduce my estrogen levels and hopefully reduce this gyno, however,

has anyone tried taking both drugs simultaneously?
letrozole to combat increased estrogen levels as a result of DHT reduction.
dutas to combat hairloss/

 

[whatevr]

I only took letrozole for 2 weeks and it destroyed my temples (major shed from that area that took 2 months to recover).

Front is very sensitive to low estrogen, so be prepared for heavy losses the longer you take it. I don't think the dutasteride will save you from that.

 

[nicksparrow]

I only took letrozole for 2 weeks and it destroyed my temples (major shed from that area that took 2 months to recover).

Front is very sensitive to low estrogen, so be prepared for heavy losses the longer you take it. I don't think the dutasteride will save you from that.

Well as of now I'm taking 2.5mg pill once a week of letrozole so starting out low dose to see if it helps with gynecomastia.
And I thought DHT was the cause for hairloss, why would reduced estrogen make it worse? Perhaps you took too high of dosage.
Perhaps a low dose of letrozole could help to regulate estrogen levels, instead of crushing them completely.

 

[Afro_Vacancy]

Well as of now I'm taking 2.5mg pill a week of letrozole so starting out low dose to see if it helps with gynecomastia.
And I thought DHT was the cause for hairloss, why would reduced estrogen make it worse? Perhaps you took too high of dosage.

I think it goes like this:

DHT hurts hair.
Estrogen helps hair.

Not sure.

 

[michel sapin]

no offense to the OP , but with only 8 pills of duta you can't have gyno . Duta need 3 month to reach steady state ,and reduce your DHT by 90 %.
Your dht decrease might be really small with only 8 pilL .
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014202/

 

[g.i joey]

OP, i suggest making your letrozole run as short as possible as nuking your estrogen comes with MANY consequences. Hair loss, libido loss, bone problems and many more, so please be cautious.

As someone who suffered exactly what you have, letrozole was able to clear up about 75-80% of any gyno symptom i had, on top of that my gland shrunk back to its original size.

For now, if i can offer any advice its take a break from the dutasteride, i know for a fact that dutasteride half life is ALOT longer than finasteride so you may need an extended break. Anyways my suggestion is take letrozole this way (keeping in midn you should be off dutasteride) .25mg day 1, .5 mg day 2, .75mg day 3 and increase in increments of .25 until you reach the full 2.5mg dose. Once you've reached the full dose you must assess your gyno symptoms and note if its made any improvement, if you have then keep on the 2.5mg dose for another week or even 2. Estrogen rebound is very real therefore i highly suggest either tapering off letrozole OR supplementing letro with a SERM and slowly tapering off as these drugs dont have the same estrogen rebound effect.

 

[michel sapin]

you might have DHT supression of 70 percent after 8 days . so the symptom like uffy nipples might occur if you are extremely sensitive to the drug .

 

[michel sapin]

joey do you think only 8 pills of duta could cause this ?? he has just begun the treatment . if h took it for 2 month i would understand but 8 days ?

 

[whatevr]

Well as of now I'm taking 2.5mg pill once a week of letrozole so starting out low dose to see if it helps with gynecomastia.
And I thought DHT was the cause for hairloss, why would reduced estrogen make it worse? Perhaps you took too high of dosage.
Perhaps a low dose of letrozole could help to regulate estrogen levels, instead of crushing them completely.

I took 0.20 mg of letrozole and had coughing fits and joint pains while being completely unable to orgasm because I didn't feel anything in my dick.
Just google it, those are the symptoms of nonexistent estrogen levels.

Anyway, DHT and estrogen are in antagonism and estrogen reverses miniaturisation, the less of it you have, the more devastated your hair will become. You will see.

 

[michel sapin]

Sure that is why transgender got great regrowyh . oestrogen allow regrowth and The anti oestrogen casuse hairloss

 

[whatevr]

Also one other thing is that if you get side effects from letrozole and if you've taken several pills (it builds up) it will take about 2 - 2.5 weeks for all the symptoms to go away while the aromatase enzyme rebuilds.

Imagine 2-3 weeks of non-stop coughing and bone and joint pains all over your body like someone is taking a saw and pneumatic drill to them all day long. Fun stuff.

 

[nicksparrow]

I took 0.20 mg of letrozole and had coughing fits and joint pains while being completely unable to orgasm because I didn't feel anything in my dick.
Just google it, those are the symptoms of nonexistent estrogen levels.

Anyway, DHT and estrogen are in antagonism and estrogen reverses miniaturisation, the less of it you have, the more devastated your hair will become. You will see.

Only .2mg? Damn. Only thing I've felt was a sudden depression/sadness past two days, crying for no reason. But it's better now. No other sides yet.

no offense to the OP , but with only 8 pills of duta you can't have gyno . Duta need 3 month to reach steady state ,and reduce your DHT by 90 %.
Your dht decrease might be really small with only 8 pilL .
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014202/

I took first 3 pills in a row. Then the other 5 every other day. But yeah after the 8th pill I noticed gynecomastia symptoms. I'm the lucky .0001% lol ;/

 

[whatevr]

I took first 3 pills in a row. Then the other 5 every other day. But yeah after the 8th pill I noticed gynecomastia symptoms. I'm the lucky .0001% lol ;/

Well, finasteride started giving me puffy nipples within 2 weeks of starting it at 0.5 mg. It's no surprise that you can have that with dutasteride which is even more powerful.

 

[nicksparrow]

So after this letrozole run to treat this gynecomastia, shall I use something softer like Arimidex instead, to go along with dutasteride and prevent future gynecomastia development by keeping estrogen in its place?

It was too early to tell if dutasteride helped with anything after 8 pills. I want to keep trying it.

 

[Alk]

No no no, stick to regiment if you literally feel gyno u can letro but for like a week. You will have horrible rebound.

 

[ajbrah]

The issue with taking dutasteride and letro simultaneously is that they will both be mutually less effective. DHT is one of the most important hormones for blocking estrogen at the receptor sites and managing serum levels, and for that reason DHT alone can reduce gyno symptoms. The more DHT, the better when it comes to treating gyno.

I have done exactly what you are contemplating, except with finasteride instead of dutasteride. The results were mediocre (maybe a 70% reduction?) and it came back pretty much immediately even though I was using tamoxifen at the end. A lot of this had to do with the fact that I did not taper off as gently as I should have.

What I would recommend sounds strange but it is working extremely well for me. I've powdered my tamoxifen pills and mixed them with some Cetaphil lotion. My dose is around 2mg tamoxifen every day along with two drops of exemestane (which is highly androgenic by AI standards) rubbed in completely, and this is working extremely well. The logic is that using this method, you can be 100% sure the drugs are penetrating the target tissue. I can feel a small "head rush" after several minutes, which tells me some is getting absorbed, but the effects on gyno reduction are profoundly improved compared to taking 20mg tamoxifen per day along with exemestane.

I also had side effects from tamoxifen orally, which I do not experience nearly as much from the topical form.

This is, again, just a personal experience. I also recommend creatine for increasing DHT levels as this will result in around a 10% rapid reduction on its own.

In total, I have reduced the size of the tissue from ping-pong ball sized (flatted and spread out) to raisin sized (flattened and spread out).

The only hair loss I experienced from all of this was when I was megadosing exemestane and injectable GH. I gained a lot of muscle during this period (and body hair), but hair loss is expected when running an AI solo. Using Nizoral on its own and no other hair loss products pretty much arrested the hair loss I experienced during that period. YMMV of course, and I'm still a NW1.

 

[nicksparrow]

The issue with taking dutasteride and letro simultaneously is that they will both be mutually less effective. DHT is one of the most important hormones for blocking estrogen at the receptor sites and managing serum levels, and for that reason DHT alone can reduce gyno symptoms. The more DHT, the better when it comes to treating gyno.

I have done exactly what you are contemplating, except with finasteride instead of dutasteride. The results were mediocre (maybe a 70% reduction?) and it came back pretty much immediately even though I was using tamoxifen at the end. A lot of this had to do with the fact that I did not taper off as gently as I should have.

What I would recommend sounds strange but it is working extremely well for me. I've powdered my tamoxifen pills and mixed them with some Cetaphil lotion. My dose is around 2mg tamoxifen every day along with two drops of exemestane (which is highly androgenic by AI standards) rubbed in completely, and this is working extremely well. The logic is that using this method, you can be 100% sure the drugs are penetrating the target tissue. I can feel a small "head rush" after several minutes, which tells me some is getting absorbed, but the effects on gyno reduction are profoundly improved compared to taking 20mg tamoxifen per day along with exemestane.

I also had side effects from tamoxifen orally, which I do not experience nearly as much from the topical form.

This is, again, just a personal experience. I also recommend creatine for increasing DHT levels as this will result in around a 10% rapid reduction on its own.

In total, I have reduced the size of the tissue from ping-pong ball sized (flatted and spread out) to raisin sized (flattened and spread out).

The only hair loss I experienced from all of this was when I was megadosing exemestane and injectable GH. I gained a lot of muscle during this period (and body hair), but hair loss is expected when running an AI solo. Using Nizoral on its own and no other hair loss products pretty much arrested the hair loss I experienced during that period. YMMV of course, and I'm still a NW1.

'flatted and spread out' ?
I thought gynecomastia had hard lumps under the nipples as glands.

No no no, stick to regiment if you literally feel gyno u can letro but for like a week. You will have horrible rebound.

How do i stop the rebound?

 

[ajbrah]

'flatted and spread out' ?
I thought gynecomastia had hard lumps under the nipples as glands.


How do i stop the rebound?

It is, but typically the lump you feel is like the tip of an iceberg and there is some additional tissue spread around and below the nipple, which is also what gives it the breast-like appearance. Kind of like if you were to flatten a raisin against a table - there would be a lump in the middle but also some less noticeable tissue spread around it thinly.

'flatted and spread out' ?
I thought gynecomastia had hard lumps under the nipples as glands.


How do i stop the rebound?

Taper off extremely slowly over the course of 2 weeks.

 

[nicksparrow]

The issue with taking dutasteride and letro simultaneously is that they will both be mutually less effective. DHT is one of the most important hormones for blocking estrogen at the receptor sites and managing serum levels, and for that reason DHT alone can reduce gyno symptoms. The more DHT, the better when it comes to treating gyno.

I have done exactly what you are contemplating, except with finasteride instead of dutasteride. The results were mediocre (maybe a 70% reduction?) and it came back pretty much immediately even though I was using tamoxifen at the end. A lot of this had to do with the fact that I did not taper off as gently as I should have.

What I would recommend sounds strange but it is working extremely well for me. I've powdered my tamoxifen pills and mixed them with some Cetaphil lotion. My dose is around 2mg tamoxifen every day along with two drops of exemestane (which is highly androgenic by AI standards) rubbed in completely, and this is working extremely well. The logic is that using this method, you can be 100% sure the drugs are penetrating the target tissue. I can feel a small "head rush" after several minutes, which tells me some is getting absorbed, but the effects on gyno reduction are profoundly improved compared to taking 20mg tamoxifen per day along with exemestane.

I also had side effects from tamoxifen orally, which I do not experience nearly as much from the topical form.

This is, again, just a personal experience. I also recommend creatine for increasing DHT levels as this will result in around a 10% rapid reduction on its own.

In total, I have reduced the size of the tissue from ping-pong ball sized (flatted and spread out) to raisin sized (flattened and spread out).

The only hair loss I experienced from all of this was when I was megadosing exemestane and injectable GH. I gained a lot of muscle during this period (and body hair), but hair loss is expected when running an AI solo. Using Nizoral on its own and no other hair loss products pretty much arrested the hair loss I experienced during that period. YMMV of course, and I'm still a NW1.

how long did it take to reduce the size, using this topical form of tamoxifen/nolvadex ? Interested to try now.