Dutasteride Is One Hell Of An Interesting F*cking Drug

whatevr

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Time is a factor also because once male pattern baldness starts or progresses you cant get the hair back its not a reversible process.

What the sh*t. Yes you can, with estrogen, cyproterone... There are people right here on this forum who posted progress pics with those regimens. Sure looks like reversal of male pattern baldness to me...
 

Thespain

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Had the same thing with finasteride at .5mg/Day, shedding increased significantly due to Telogen Effluvium and my male pattern baldness sped up significantly as well, had all the sides you had except the libido thing. I went back down to a much lower level, I cut the 1mg pills into 7 pieces. Been doing this for a month, shedding has slowed, and the best part is those damn burning/tingling/itching/creepy-crawly feelings went away almost entirely, hair is looking a bit thicker. Maybe try dropping your dose, your body could be like, compensating with increased androgen levels, just more then it does for the normal person, and maybe a lower dose would work better in your situation.

The only thing that leads me to believe that the higher dose for me made my androgen levels super high is the fact that I since I lowered my dose I gained a bit of fat and lost some strength/muscle when I didn't even change my diet or routine. So maybe our bodies are very sensitive to too much change and combats it.
 

GoldenMane

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How much more potent is DHT than Testosterone in terms of affinity for ARs? I just find it odd that ARs can become unregulated despite the increased amount of testosterone floating around when on 5a reductase inhibitors. It's not like they actually reduce overall androgens, just DHT, and testosterone should increase by the same amount DHT is reduced. I know some Testosterone is converted to estrogen but it wouldn't be enough to starve the androgen receptors of testosterone would it?
 
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GoldenMane

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Of course if you're blocking the receptors themselves then you're blocking both androgens in which case I can see AR upregulation being more likely. One reason why the likes of equol and spironolactone slightly worry me.
 

Ruby

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What the sh*t. Yes you can, with estrogen, cyproterone... There are people right here on this forum who posted progress pics with those regimens. Sure looks like reversal of male pattern baldness to me...

Some of us are betting the farm on it.
 

lifewithouthair

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Buckthorn, what brand of dutasteride do you use?, brand name or generic?.

I just got my DHT levels checked. And guess what?, their above average levels. Actually pretty high.

658.4 with a ref range of 250 to 990. pg/ml

I have been taking finpecia for the last four or three years, and duprost- both cipla products, for the last 3 months and seen basically next to no results except gradual worsening of my crown.

How is it possible to have such high dht levels despite being on dual inhibitors?, it doesn't make any sense since dutasteride and finasteride reduce DHT levels by 90% and 70% respectively.

I have to mention that I did use spironolactone a few months back but quit as soon as read about the potential sides. Started Duprost then. Could this have thrown my hormones out of whack?. But then again i never saw results even before spironolactone.

Today I purchased Dr reddy's Dutas and Finax. Can anyone attest and confirm their efficacy?

I feel like I just wasted four years of my life taking bunk pills, I don't know how this is possible. I mean cipla is a pretty reputed brand from what I read everywhere. Am I an unlucky anomaly?.

I have seen just one post on TBT forum from a member who tested his Dht on Dutas and saw actual reduction in the hormone.

This whole ordeal has emphasized how important it is to monitor hormones. Kinda wish I checked earlier tbh.
 
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buckthorn

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Buckthorn, what brand of dutasteride do you use?, brand name or generic?.

I just got my DHT levels checked. And guess what?, their above average levels. Actually pretty high.

658.4 with a ref range of 250 to 990. pg/ml

I have been taking finpecia for the last four or three years, and duprost- both cipla products, for the last 3 months and seen basically next to no results except gradual worsening of my crown.

How is it possible to have such high dht levels despite being on dual inhibitors?, it doesn't make any sense since dutasteride and finasteride reduce DHT levels by 90% and 70% respectively.

I have to mention that I did use spironolactone a few months back but quit as soon as read about the potential sides. Started Duprost then. Could this have thrown my hormones out of whack?. But then again i never saw results even before spironolactone.

Today I purchased Dr reddy's Dutas and Finax. Can anyone attest and confirm their efficacy?

I feel like I just wasted four years of my life taking bunk pills, I don't know how this is possible. I mean cipla is a pretty reputed brand from what I read everywhere. Am I an unlucky anomaly?.

I have seen just one post on TBT forum from a member who tested his Dht on Dutas and saw actual reduction in the hormone.

This whole ordeal has emphasized how important it is to monitor hormones. Kinda wish I checked earlier tbh.

What the hell? I can't believe your DHT levels are that high while on dutasteride!! I don't know what to tell you man. Perhaps the dutasteride you're taking is fake? Or the body has somehow counteracted it by producing large amounts if testosterone? idk. what are your testosterone levels?
I get my dutasteride through Murray Ave. Apothecary and it's legit. I have heard Dr. Reddy's is legit as well.
 

lifewithouthair

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What the hell? I can't believe your DHT levels are that high while on dutasteride!! I don't know what to tell you man. Perhaps the dutasteride you're taking is fake? Or the body has somehow counteracted it by producing large amounts if testosterone? idk. what are your testosterone levels?
I get my dutasteride through Murray Ave. Apothecary and it's legit. I have heard Dr. Reddy's is legit as well.

Yeah, From now on i'll be keeping a close eye on my DHT levels.
 

horunger

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2) VIVID, weird sex dreams, like I haven't had since I was 15. Rock hard erections all through the night.
Small dose finasteride had a somewhat similar but more limited effect on me, sexual function and quality definitely improved at first but then went gradually back to normal. A few days without finasteride and then restarting it in a higher initial dose on day 1 and the extra sexual function came back again. dutasteride may have a very strong effect for me as well then same as you, will try, eventually.
 

horunger

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By the way, you've got balls, @buckthorn. I would be too scared to try dutasteride, taking into account my total loss of libido and erections with 1,25 mg of finasteride ed. But if it works for you, and you even get a libido boost without undesirable side effects, you should feel satisfied, am I wrong?
Sounds right, if you had ED on finasteride i doubt dutasteride is a good idea for you, especially since dutasteride stays so long in the body, it can take 3-8 weeks for the wood to return after stopping dutasteride.

Strange why some of us, like me and buckthorn, get more wood from DHT reduction meds, it was so much more than "a little improvement", a wild guess would be that a slightly overactive thyroid function is involved.
 

buckthorn

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Strange why some of us, like me and buckthorn, get more wood from DHT reduction meds, it was so much more than "a little improvement", a wild guess would be that a slightly overactive thyroid function is involved.

Horunger, did you ever try dutasteride? How long were you on finasteride, and if you don't mind, can you give me a thorough account of your experience? did it increase hair loss?
 

Mach

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It's been long debated that generic might be absorbed differently than brand.
I buy brand for piece of mind. I THINK I remember guys drinking grapefruit juice with finasteride to increase absorption.
 

horunger

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Horunger, did you ever try dutasteride? How long were you on finasteride, and if you don't mind, can you give me a thorough account of your experience? did it increase hair loss?
Not tried dutasteride yet. I only tested finasteride in a low dose for 6 months, had unexpected good regrowth and some recovery of miniaturized hairs, impressive enough considered im a high Norwood already but not enough regrowth to justify continuation. Will buy some dutasteride and bring home from an asian vacation in sep/oct, i will not start while i am there just in case its not like finasteride, we wouldnt want to disappoint any chinese sl*ts of Kowloon City now would we, that would be rude =) The plan is to pick up generic dutasteride in Manila, both finasteride and dutasteride are sold without prescription in some reliable pharmacies but prices are on the high side there.

Edit: No hairloss on finasteride, no more than normal.
 
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buckthorn

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we wouldnt want to disappoint any chinese sl*ts of Kowloon City now would we, that would be rude =).

hahahaha!!! YOU DOG!
 

horunger

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It's been long debated that generic might be absorbed differently than brand.
I buy brand for piece of mind. I THINK I remember guys drinking grapefruit juice with finasteride to increase absorption.
Its not something that can be proven in blind tests, can safely be disregarded. Fake generics is another thing, but fakers tend to use famous brand names, like it is with fake v****, one could speculate that generics have a bigger chance of being genuine in such places. As for grapefruit juice, there are probably good reasons why we havent heard about it, people get caught up in little things they do and ignore the big ones, like this lady who said low alcohol beer healed her UTI and "forgot" to mention she was taking Amoxicillin at the same time and how her 2 previous beer cures wich didnt involve amoxicillin had no effect on the UTI.
 

Mach

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Its not something that can be proven in blind tests, can safely be disregarded. Fake generics is another thing, but fakers tend to use famous brand names, like it is with fake v****, one could speculate that generics have a bigger chance of being genuine in such places. As for grapefruit juice, there are probably good reasons why we havent heard about it, people get caught up in little things they do and ignore the big ones, like this lady who said low alcohol beer healed her UTI and "forgot" to mention she was taking Amoxicillin at the same time and how her 2 previous beer cures wich didnt involve amoxicillin had no effect on the UTI.
It's not about being fake but the inactive ingredients that could effect absorption. Grapefruit juice has been talked about sense early 2000s on this forum. I haven't seen it being brought up lately. Maybe because it's BS?
 

horunger

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I have been taking finpecia for the last four or three years, and duprost- both cipla products, for the last 3 months and seen basically next to no results except gradual worsening of my crown.
Unfortunately all too common, finasteride just doesnt give good results over time, dutasteride is our only option. I strongly recommend everyone to not waste valuable time on finasteride, go straight to dutasteride. I just started dutasteride and side effects so far are smaller than finasteride, and my already adequate sexual ability increased almost immediately, just an hour after the first capsule. Wish i started dutasteride long ago.
 

jetlife1

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Hey @horunger you're full of sh*t!!!! Finasteride is effective in greater than 90% of men with androgenetic alopecia after 10 years and is actually said to be more effective with time as you're hair growth should increase/improve with every hair cycle. I can attest to this.
 

Massive

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Unfortunately all too common, finasteride just doesnt give good results over time, dutasteride is our only option. I strongly recommend everyone to not waste valuable time on finasteride, go straight to dutasteride. I just started dutasteride and side effects so far are smaller than finasteride, and my already adequate sexual ability increased almost immediately, just an hour after the first capsule. Wish i started dutasteride long ago.

Were you on finasteride before you took dutasteride today for the first time ?

Were you a good responder to finasteride ?
 

horunger

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Hey @horunger you're full of sh*t!!!! Finasteride is effective in greater than 90% of men with androgenetic alopecia after 10 years and is actually said to be more effective with time as you're hair growth should increase/improve with every hair cycle. I can attest to this.
Thats true for some but not all, and the finasteride results are nowhere near long term dutasteride users. When dutasteride in addition seem to have less severe side effects then we can leave it to people to draw their own conclusions. Better effect, lower side effects, let each and every one chose who is more full of sh*t here.

Edit: additionally, lets not ignore the large number of finasteride users here who have slowly but surely lost hair while on it, that was the basis of my comment, the 90% good responders you talk about are not to be found here. And post your awesome 10 year result please, or keep quiet.
 
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