Dutasteride's Protein Binding (Using dutas topically?)

[outbulk]

Hey GourmetStyleWellness,

I was researching Dutasteride, and according to Wikipedia it has a protein binding of 99%. This means that 99% of dutas will be bound to plasma proteins in the blood, making the amount of active dutas way lower, and the drug will be released a lot slower from the blood.

Based on this, it makes sense that the dutas will be in free form on the place of application, but be more bound to proteins as it goes systemically. So the effectiveness of dutas will be be less the further it travels in the body, making the risk of sides lower, right?

Anybody can confirm this?


Going on finasteride anyway after I've seen my dermatologist in 2 weeks (for the prescription), but figured my hair would need something stronger as I'm already balding quite fast at 18.

 

[Agustin Araujo]

I think using a 5-AR inhibitor topically probably won't do anything; taking it orally is the best route. If you're young and balding rapidly, definitely go for Dutasteride since Finasteride could be a little too weak to halt your Androgenetic Alopecia.

 

[outbulk]

Why would orally (= systemically) do more than topically? From what I've read, the 5-AR enzyme works locally (correct me if I'm wrong). Blood DHT might have an effect on the follicle, but it's quantity would be quite low, right?

Especially when using a strong inhibitor like dutasteride, there would be very little DHT left locally.

I'm not a pharmacist or doctor but it seems to make sense.

Anybody with experience on topical dutas on the forum?

 

[DontWant2BeBald]

The thing is that nobody knows if taking it topically will reach to the bottom of the follicle for it to take affect.

Im not turkish but I went to the turkish forum and there was a lot of people using topical dutasteride+minoxidil there


Heres the site link: http://www.sacimindoktoru.com/forum.php

Use google translate to get around.

I do believe topicals work though. Only because I have used s5 cream in the past and my hairloss was much slower back then, but that could be a coincidence.

 

[outbulk]

The thing is that nobody knows if taking it topically will reach to the bottom of the follicle for it to take affect.

Im not turkish but I went to the turkish forum and there was a lot of people using topical dutasteride+minoxidil there


Heres the site link: http://www.sacimindoktoru.com/forum.php

Use google translate to get around.

I do believe topicals work though. Only because I have used s5 cream in the past and my hairloss was much slower back then, but that could be a coincidence.

Thank you, I'll read about it on the turkish forum.