Interesting. I always had a general understanding of horomones and their respective receptors, but not at this detail. Assuming other advanced and effective treatments for hair loss are not developed, I wonder if SARM's might ever enter the ring to replace finasteride.
Everything we need to know about Androgen Receptors
- Thread starter Danik0226
- Start date
I'm trying to understand this, but it's hurting my brain !
I think I get the first parts of it - how the androgens enter the cell and then bind to the androgen receptor. After that, I get kind of lost but thats ok...
My main question is in regards to something like CB, where it binds to the androgen receptor, but then what happens? Most importantly I don't understand the timing of all of this - after CB binds to the androgen receptor, what happens to it and how long does it take for the follicle to develop a new androgen receptor? Is there only one androgen receptor per follicle, or several?
A video animation would be sooooooo helpful lol.
I think I get the first parts of it - how the androgens enter the cell and then bind to the androgen receptor. After that, I get kind of lost but thats ok...
My main question is in regards to something like CB, where it binds to the androgen receptor, but then what happens? Most importantly I don't understand the timing of all of this - after CB binds to the androgen receptor, what happens to it and how long does it take for the follicle to develop a new androgen receptor? Is there only one androgen receptor per follicle, or several?
A video animation would be sooooooo helpful lol.
finfighter said:
Yeah this was my concern... because say CB binds to the androgen receptor, then the androgen receptor "goes away" for a while until a new one is generated.
How quickly this happens is what I kind of wanted to know, because if a new androgen receptor is generated and there is no CB present, we can assume DHT will be binding to it, no? Also curious is to how quickly DHT binds to to the androgen receptor upon its inception... wouldn't you assume there would always be some DHT in the scalp because your body is continuously producing testosterone. So if a new androgen receptor pops up, wouldn't DHT bind to it almost instantaneously?
And what if you apply CB when there are no (or very few) available androgen receptors?? Ahhhhh so confusing... but I guess if the studies show it is effective once or twice a week that is a good sign. Would be nice to understand it though lol
optimus prime
Experienced Member
- Reaction score
- 12
Does RU58841 bind to the receptors like CB or does it block the receptors so nothing blinds to them?
The reason I ask is I remember a thread a while ago that suggested that the body can detect that the receptors are not binding with anything and then creates more receptors. Suggesting that after many years of use RU would become less affective.
However, if RU & CB bind with the receptor, how does the body know what is binding with it and won't it just accept that it does not need to create more receptors?
The reason I ask is I remember a thread a while ago that suggested that the body can detect that the receptors are not binding with anything and then creates more receptors. Suggesting that after many years of use RU would become less affective.
However, if RU & CB bind with the receptor, how does the body know what is binding with it and won't it just accept that it does not need to create more receptors?
Hey finasteride, I posted this on the previous page but no response... I don't know if you can answer it, but I'll post it again:
So essentially I get HOW CB/antagonists bind to the androgen receptor, and that they have a higher affinity for the androgen receptor compared to Test/DHT.
I don't understand the timing though. One thing I wonder is if when you apply CB to your scalp, the molecules STAY there for a while (say a few days???)... so when a new androgen receptor pops up (presumably every few days... maybe daily though?), CB can bind to it before DHT does. Is this why Cosmo found success with applications only once or twice a week?
So essentially I get HOW CB/antagonists bind to the androgen receptor, and that they have a higher affinity for the androgen receptor compared to Test/DHT.
I don't understand the timing though. One thing I wonder is if when you apply CB to your scalp, the molecules STAY there for a while (say a few days???)... so when a new androgen receptor pops up (presumably every few days... maybe daily though?), CB can bind to it before DHT does. Is this why Cosmo found success with applications only once or twice a week?