Exploring The Hormonal Route. Hair=life.

[Adri23]

After 1 year and 6 months of HRT I conclude I have a short of estrogen insensitivity. My hair is worse than ever and I have very low feminization overall. When I was not using HRT I did a genetic test and it said I had very reduced aromatase activity so I wouldn't be surprise if I have estrogen insensitivity. Even with levels of 450 pg/ml at trough my SHBG does not rise further than 74 nmol/L which is very low in comparison of the estradiol levels.

 

[Fvgwnx]

cpa cannot interfere with the work of duta and finasteride? I've been taking blowout and finn for 3 months now. and I don’t see the result, just small colorless hairs of 1 cm.

 

[SnortingFinasteride]

After 1 year and 6 months of HRT I conclude I have a short of estrogen insensitivity. My hair is worse than ever and I have very low feminization overall. When I was not using HRT I did a genetic test and it said I had very reduced aromatase activity so I wouldn't be surprise if I have estrogen insensitivity. Even with levels of 450 pg/ml at trough my SHBG does not rise further than 74 nmol/L which is very low in comparison of the estradiol levels.

Maybe your high trough estrogen levels have downregulated the Estrogen Receptors somewhat ?


450 pg/ml is pretty high for a trough level. And googling "Estrogen insensitivity" yields a very, very rare condition (much rarer than Androgen insensitiviy)

 

[SnortingFinasteride]

cpa cannot interfere with the work of duta and finasteride? I've been taking blowout and finn for 3 months now. and I don’t see the result, just small colorless hairs of 1 cm.

Give it a year or 2. Hair grows extremely slowly

 

[Adri23]

Maybe your high trough estrogen levels have downregulated the Estrogen Receptors somewhat ?


450 pg/ml is pretty high for a trough level. And googling "Estrogen insensitivity" yields a very, very rare condition (much rarer than Androgen insensitiviy)

No, I lowered my levels to 318 pg/ml still the same .... Also e2 receptors does not downregulate unless you have much higher SHBG than mine cause SHBG is the marker that says to your body your e2 is too high and start to downregulate when high.

 

[SnortingFinasteride]

No, I lowered my levels to 318 pg/ml still the same .... Also e2 receptors does not downregulate unless you have much higher SHBG than mine cause SHBG is the marker that says to your body your e2 is too high and start to downregulate when high.

All SHBG does is bind to sex hormones and makes it harder for the body to use them. It doesn't interfere with receptor sensitivity. It also prefers binding to androgens more so than estrogens

Estrogen insensitivity is a syndrome on a genetic level. Meaning you are born with such condition. I think if you had such condition, your bones would be brittle by now.

Check your DHT levels, and if possible DHEA and Androstenedione levels as well. Adrenal androgens could hinder feminisation

 

[Adri23]

All SHBG does is bind to sex hormones and makes it harder for the body to use them. It doesn't interfere with receptor sensitivity. It also prefers binding to androgens more so than estrogens

Estrogen insensitivity is a syndrome on a genetic level. Meaning you are born with such condition. I think if you had such condition, your bones would be brittle by now.

Check your DHT levels, and if possible DHEA and Androstenedione levels as well. Adrenal androgens could hinder feminisation

This: https://www.ncbi.nlm.nih.gov/pmc/ar...ristics, and exhibit progressive virilization.

My blood test:

Total T: 26 ng/dl.
Free T: 1.6 pg/ml.
DHT: 4,98 ng/dl.
3a diol G: 0.52 ng/ml.
Androstenodione: 110 ng/dl.
E2: 388.1 pg/ml.
Estrone: 138. pg/ml.
SHBG: 85.5 nmol/L.
FSH: <0.30 mUI/ml.
LH: 0.39 mUI/ml.
DHEA: 2.48 ng/mL.
DHEA-S: 219.7 µg/dL.
Prolactin: 13.1 ng/ml.
PSA: 0.040 ng/ml.
Somatomedin C(IGF-1): 180 ng/ml

 

[SnortingFinasteride]

This: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939057/#:~:text=Aromatase deficiency results from autosomal,characteristics, and exhibit progressive virilization.

Doesn't say anything about high SHBG downregulating the estrongen receptors. And your SHBG isn't high to be fair, seems quite consistent with cis females

In any case, your hormonal profile looks to be in range with cis women.

looking at your regimen, you may need to up the Bicalutamide dosage to 50mg everyday

 

[Adri23]

Doesn't say anything about high SHBG downregulating the estrongen receptors. And your SHBG isn't high to be fair, seems quite consistent with cis females

In any case, your hormonal profile looks to be in range with cis women.

looking at your regimen, you may need to up the Bicalutamide dosage to 50mg everyday

The thing is, I used to use bica 25 mg daily which is enough for my body with that blood test but even that didn't improve my hair a tiny bit.

 

[SnortingFinasteride]

Free T 1.6 lmfao no wonder your hair is nuked

1.6 pg/ml seems to be in range for cis females bruh

 

[SnortingFinasteride]

The thing is, I used to use bica 25 mg daily which is enough for my body with that blood test but even that didn't improve my hair a tiny bit.

How long did you give it before judging that it has no effect ?

 

[Adri23]

How long did you give it before judging that it has no effect ?

9 months.

First pic was my hair on april (10 months hrt) and the second pic is today (1 year 6 months hrt)

The blood test for the first pic was:

Total T: 25 mg/dl
Free T: 1.7 pg/ml
DHT: 6.42 ng/dl
3a diol G: 0.42 ng/ml
Estradiol: 278.5 pg/ml
SHBG: 61 nmol/L
FSH: <0.30 mUI/ml
LH: 0.15 mUI/ml
DHEA-S: 220.1 μg/dl
Prolactin: 33 ng/ml
PSA: 0.08 ng/ml

 

[SnortingFinasteride]

“Cis” lol what are you some Biden loving fa880t

Indeed. I am a Biden loving fa eight-eight-zero t

 

[SnortingFinasteride]

he’s not a female

Doesn't matter dumbfÛk.

 

[SnortingFinasteride]

All this science being spilled yet conclusion is the same: It’s over.

View attachment 186159

It's over for the weak willed

 

[SnortingFinasteride]

9 months.

First pic was my hair on april (10 months hrt) and the second pic is today (1 year 6 months hrt)

The blood test for the first pic was:

Total T: 25 mg/dl
Free T: 1.7 pg/ml
DHT: 6.42 ng/dl
3a diol G: 0.42 ng/ml
Estradiol: 278.5 pg/ml
SHBG: 61 nmol/L
FSH: <0.30 mUI/ml
LH: 0.15 mUI/ml
DHEA-S: 220.1 μg/dl
Prolactin: 33 ng/ml
PSA: 0.08 ng/ml

You need to try Bicalutamide 50 mg. This is further proof that HRT isn't some magic cure to male pattern baldness

 

[Adri23]

You need to try Bicalutamide 50 mg. This is further proof that HRT isn't some magic cure to male pattern baldness

But idk bica + dutas long term do not seem ok for liver in my head

 

[SnortingFinasteride]

But idk bica + dutas long term do not seem ok for liver in my head

It isn't. That's why you either take blood tests every 3 months or so, to ensure that your liver enzymes are still within normal range. Or, you make due with what you've got.

Perhaps when enzalutamide gets cheaper (patent expiry is circa 2027), you replace Bica with Enza since it is supposedly way stronger

 

[SnortingFinasteride]

View attachment 186160
I agree. Lets fix this problem once and for all!!





Lmao

"Commited suîcide because he was balding" lmfao

 

[Adri23]

It isn't. That's why you either take blood tests every 3 months or so, to ensure that your liver enzymes are still within normal range. Or, you make due with what you've got.

Perhaps when enzalutamide gets cheaper (patent expiry is circa 2027), you replace Bica with Enza since it is supposedly way stronger

Yeah for now I'm taking blood test every 3 months. So I will prob continue with bica for as long as I can(I'm not sure tho)

Idk if I will have hair till 2027 but if it gets cheaper and available on DIY websites I may try it.