Was already on a high dose of it, massive dose and it wasn’t working. In fact it caused more itching and acne etc. You have to figure, aside from receptor upregulation, it also raises T quite a bit. Bica works by outnumbering the androgens in volume, but molecule for molecule it has a very weak affinity for AR. It’s certainly no match for DHT. The other factor most people don’t realize is that all that excess T can still be converted to DHT via intracellular mechanisms. Even if you are on a 5ARI we already know that the significant blockage occurs in the serum. However, these drugs only block scalp DHT by 50%. This is because, unlike T, DHT is a paracrine hormone (it is produced in the local cells). Thus, the spike in serum T from bica can reach the scalp to the cells of the hair follicle and be converted to DHT. Not all of it, but some of it will be enough to continue to do the damage, especially since the AA will upreg AR.