Exploring The Hormonal Route. Hair=life.

I'mme

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With men, it's a different situation since we respond better to hair loss medications evidently.

Really, is that true? About 3 months in and things have only gone worse. Before treatment, I would only lose 5-30 hair but now I shed more than 100. Things seem to be improving though.

You have to remember women can take AAs easily - they won't have to turn into a male to preserve their hair whereas for us men... You know it.
 

Ikarus

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Really, is that true? About 3 months in and things have only gone worse. Before treatment, I would only lose 5-30 hair but now I shed more than 100. Things seem to be improving though.

You have to remember women can take AAs easily - they won't have to turn into a male to preserve their hair whereas for us men... You know it.

Women have it much worse, since they have a significantly greater sensitivity to androgens compared to us. It's harder to treat in a lot of cases, especially with the limited amount of medications which can be prescribed by doctors. I meant that men respond better to medications because we have a greater sensitivity to the effects of estrogen, which could explain why there are significantly more success stories of male anti-androgen users compared to female anti-androgen users, especially within shorter time-periods.
 

Yar

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The fact is that in order to increase body weight, cattle are fed with supplements containing hormones. And 80% of the hormones that are added to feed pigs for a rapid increase in the number ... That is why it is during this period that an increase in body weight can be observed. Testosterone is used to increase body weight.
 

I'mme

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Women have it much worse, since they have a significantly greater sensitivity to androgens compared to us. It's harder to treat in a lot of cases, especially with the limited amount of medications which can be prescribed by doctors. I meant that men respond better to medications because we have a greater sensitivity to the effects of estrogen, which could explain why there are significantly more success stories of male anti-androgen users compared to female anti-androgen users, especially within shorter time-periods.
Makes sense. Thanks!
 

Father_of_Shiseido

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I never understood how the crown is easier to recover with meds, but the most difficult to recover with a transplant.
My Crown is the only part which isn't responding to spironolactone. I have started topical estradiol. It gives me racing hurt. I never knew that it's a possible side effect of estradiol.
 

I'mme

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My Crown is the only part which isn't responding to spironolactone. I have started topical estradiol. It gives me racing hurt. I never knew that it's a possible side effect of estradiol.
If that calcification/fibrosis theory is true, try stronger minoxidil solution. I wouldn't place much hopes on estradiol because it works only by going systematic. As for aromatase specifically on scalp, even alcohol in minoxidil does that. It is your wish however.
 

Father_of_Shiseido

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If that calcification/fibrosis theory is true, try stronger minoxidil solution. I wouldn't place much hopes on estradiol because it works only by going systematic. As for aromatase specifically on scalp, even alcohol in minoxidil does that. It is your wish however.
I am already drinking 0.5 ml minoxidil but to no avail.
 

Ein

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@Ein if you're still around, have you had your testosterone levels checked?
Nope, I haven't got any tests in forever. So, I can't attest to your claims. But I feel like I'm doing good. Also, a couple of days ago, I started using Estrogel (0.06%, meh) on my hairline and face, because even if my hairline is very round and low, it's not symmetrical and I've got a bunch of fuzzy hairs on the left side of my widow's peak and I want my hairline to come down to the lowest point of my widow's peak, even if it's like 50% scanty so I can use Dermmatch to make is symmetrical and awesome AF.
There's a concern though that's being raised lately about its metabolism to metabolites like estriol and estriol sulphate.
Anyone got any suggestions? (I know, I know, I'm being very petty, and I'm sorry for that.)
 
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Father_of_Shiseido

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No no, you'll have to apply it topically in the area where fibrosis has taken place, otherwise other treatments will not be that effective.
I used to apply 3 ml of minoxidil there for the last three years. I stopped topical minoxidil because it wasn't working.
 

Father_of_Shiseido

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Nope, I haven't got any tests in forever. So, I can't attest to your claims. But I feel like I'm doing good. Also, a couple of days ago, I started using Estrogel (0.06%, meh) on my hairline and face, because even if my hairline is very round and low, it's not symmetrical and I've got a bunch of fuzzy hairs on the left side of my widow's peak and I want my hairline to come down to the lowest point of my widow's peak, even if it's like 50% scanty so I can use Dermmatch to make is symmetrical and awesome AF.
There's a concern though that's being raised lately about its metabolism to metabolites like estriol and estriol sulphate.
Anyone got any suggestions? (I know, I know, I'm being very Petty, and I'm sorry for that.)
@Ein ; did you ever noticed that your testicles have shrunken?
 

I'mme

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Nope, I haven't got any tests in forever. So, I can't attest to your claims. But I feel like I'm doing good. Also, a couple of days ago, I started using Estrogel (0.06%, meh) on my hairline and face, because even if my hairline is very round and low, it's not symmetrical and I've got a bunch of fuzzy hairs on the left side of my widow's peak and I want my hairline to come down to the lowest point of my widow's peak, even if it's like 50% scanty so I can use Dermmatch to make is symmetrical and awesome AF.
There's a concern though that's being raised lately about its metabolism to metabolites like estriol and estriol sulphate.
Anyone got any suggestions? (I know, I know, I'm being very petty, and I'm sorry for that.)

I know you are agender. But don't your parents say anything seeing you taking these drugs. You must have obviously feminised.

Enuf of bs, coming to the point, Do you still shed hair?
 

Ein

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Anti-androgens reduces testicular function.
Bicalutamide has a very low binding capacity as compared to regular androgens like testosterone and DHT. The only reason it's able to work for hair loss is because of its elimination half life. Since its elimination half life is around a week, its concentration builds up inside the body and thanks to basic chemical kinetics [the rate of a reaction is the product of the rate constant and (a power of) the concentration of its reactants; the rate constant gives it away for bicalutamide but concentration declares its victory in hairloss].
Now in the gonads and genitals, thanks to the androgen surge due to blockade of androgen receptor in hypothalamus, the concentration of testosterone and DHT is so high that there is no way bicalutamide can bind to even a single receptor.
So, no shrinking of testicles, no other sexual side effects.

I know you are agender. But don't your parents say anything seeing you taking these drugs. You must have obviously feminised.
Yes, my parents do say some things but not a lot. And for that matter, hair loss is a big issue of self esteem, so grave that I was able to convince them to let me take this step, and to my surprise, even my father takes bicalutamide now, hoping his hair would return. I don't have a problem with that, since it can prevent prostate cancer too.
Do you still shed hair?
Well, yes. Never more than 100 (I hate you shampoo days), never less than 10, but I have this crazy habit of constantly combing through my long hairs, so I guess I can't complain. I'm still sceptical of whether this claim of shedding 50-100 hairs a day being normal is really authentic or not. (I can notice all of my shedding because my hair is pretty much all the time in a shower cap.)
Also, I shampoo only once a week, because I've got very less sebum production after starting the treatment.
 

I'mme

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Bicalutamide has a very low binding capacity as compared to regular androgens like testosterone and DHT. The only reason it's able to work for hair loss is because of its elimination half life. Since its elimination half life is around a week, its concentration builds up inside the body and thanks to basic chemical kinetics [the rate of a reaction is the product of the rate constant and (a power of) the concentration of its reactants; the rate constant gives it away for bicalutamide but concentration declares its victory in hairloss].
Now in the gonads and genitals, thanks to the androgen surge due to blockade of androgen receptor in hypothalamus, the concentration of testosterone and DHT is so high that there is no way bicalutamide can bind to even a single receptor.
So, no shrinking of testicles, no other sexual side effects.


Yes, my parents do say some things but not a lot. And for that matter, hair loss is a big issue of self esteem, so grave that I was able to convince them to let me take this step, and to my surprise, even my father takes bicalutamide now, hoping his hair would return. I don't have a problem with that, since it can prevent prostate cancer too.

Well, yes. Never more than 100 (I hate you shampoo days), never less than 10, but I have this crazy habit of constantly combing through my long hairs, so I guess I can't complain. I'm still sceptical of whether this claim of shedding 50-100 hairs a day being normal is really authentic or not. (I can notice all of my shedding because my hair is pretty much all the time in a shower cap.)
Also, I shampoo only once a week, because I've got very less sebum production after starting the treatment.
Why do I see all Indians here are extremely educated?

I don't know how would my parents react if spironolactone provides me some feminization. They would hardly notice though, even if they do only mom would say sth if she does.


Re shedding, I have been reading about it. For those finasteride/dutasteride works, they have reduction/halt in shedding/hair loss, whereas most people on AAs continue to lose hair but they have tremendous regrowth that compensate for shedding. Dunno why this happens.
 

Ein

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Why do I see all Indians here are extremely educated?
It's been two years of reading and re-reading and researching and re-researching for me, though I stopped after a year because of my college. I feel like I've missed out on so many cool updates about different types of regimens. Sigh, I'm not that well educated on this topic anymore, but whatever, thanks.
They would hardly notice though, even if they do only mom would say sth if she does.
My parents do notice changes and my father keeps complaining about gynecomastia, but I don't let him win. With all the science I can use to counterargument his complaints, I always win. Just yesterday, he brought me my new stock of bicalutamide for the next five months. So cool, right?
Re shedding, I have been reading about it. For those finasteride/dutasteride works, they have reduction/halt in shedding/hair loss, whereas most people on AAs continue to lose hair but they have tremendous regrowth that compensate for shedding. Dunno why this happens.
This is so wrong, right? I know that people with thick hair shed more than those with thin hair, and obviously, my scalp is much less visible now, so obviously I've thickened up, but on the expense of leaving trails of long hair everywhere I go in my college where I can't live with my shower caps 24×7. I wish there was a way to stop this eternal shedding.
 

I'mme

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It's been two years of reading and re-reading and researching and re-researching for me, though I stopped after a year because of my college. I feel like I've missed out on so many cool updates about different types of regimens. Sigh, I'm not that well educated on this topic anymore, but whatever, thanks.

My parents do notice changes and my father keeps complaining about gynecomastia, but I don't let him win. With all the science I can use to counterargument his complaints, I always win. Just yesterday, he brought me my new stock of bicalutamide for the next five months. So cool, right?

This is so wrong, right? I know that people with thick hair shed more than those with thin hair, and obviously, my scalp is much less visible now, so obviously I've thickened up, but on the expense of leaving trails of long hair everywhere I go in my college where I can't live with my shower caps 24×7. I wish there was a way to stop this eternal shedding.
What is wrong? You said, that is wrong and went on to explain what I said was right?! Sorry I did not get this. :)

Did your father see any improvement?
 
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