Exploring The Hormonal Route. Hair=life.

[DHTcel]

Bicalutamide, as far as, I know doesn't do much to DHEA.
A study concluded - Conclusions:  Our data show that flutamide suppresses the adrenal androgens in comparison with bicalutamide. The responsiveness and response duration of flutamide can be predicted in patients with a higher baseline androstenediol level and a lower DHEA level. Metabolites from adrenal androgens contribute to the progression of prostate cancer."

DHEA and other adrenal androgens have a 15-30x lower binding affinity than DHT does for the Androgen Receptor.
Testosterone has a 2-3x lower affinity than DHT so its just as bad considering its 10-15x more abundant as an androgen.

 

[I'mme]

I've used spironolactone for about 10 months now. After the first 4 months I tried increasing my dosage from 100mg to 150mg. But it started giving me dark circles under my eyes and overall kinda just hollowing my face out in a negative way, so I had to cut back to 100mg. Obviously everyone is different, but I've seen this characteristic in numerous spironolactone users. Might have to do with it being a diuretic. Also, whenever I would stand up I would immediately get light headed due to the decreased blood pressure. Not sure I could go anywhere near 400mg without feeling and looking like a zombie.

No no, hollow cheeks looks great. Even if not from front (depending on face), from sides at least.

I agree about its diuretic effect. I never take more than 100mg at once.

People have done that, - maybe our body start taking it well after some days.

 

[I'mme]

It did the same to me. I am much more knowledgeable about how the human body works than i was before i had hair loss, i wouldn't say i'm smarter though because hair loss kept me from finishing college, i was losing my mind over it and stopped going to my classes to focus on how to reverse balding, a lot of time gone doing research and obsessing, but at least i know how to prevent a bald head now and i can finish school with peace of mind lol.

I did that in +1, +2 but the only difference is I topped both my school as well as coaching. Learn from me. Lol

 

[I'mme]

For sure. I spent a couple years buzzing my head to try and "accept" it.

f***, you look fckin beautiful. Do you have any preference for dating 19yo boys haha?

 

[I'mme]

DHEA and other adrenal androgens have a 15-30x lower binding affinity than DHT does for the Androgen Receptor.
Testosterone has a 2-3x lower affinity than DHT so its just as bad considering its 10-15x more abundant as an androgen.

Hey mate! How have your results been? Has it completely stopped your hair loss?

 

[I'mme]

Bicalutamide, as far as, I know doesn't do much to DHEA.
A study concluded - Conclusions:  Our data show that flutamide suppresses the adrenal androgens in comparison with bicalutamide. The responsiveness and response duration of flutamide can be predicted in patients with a higher baseline androstenediol level and a lower DHEA level. Metabolites from adrenal androgens contribute to the progression of prostate cancer."

" concentrations of PRL, total T, A, DHEA, or DHEA-S. No difference was observed, however, in the induction of these endocrine changes between the Diane and Androcur groups"

So ditto for CPA. But even role of DHEA has been found by very few studies and Iirc most of them found its role in prostate cancer. Only two studies found its role in AA

 

[I'mme]

@bridgeburn @Sonolmn98 Thanks for providing your two cents.

However, I can't help but to disagree. For one, I have seen many bald homeless men and many hairy homeless men. I have seen many vegans with hair and those without. There isn't a 1+1 formula here.

Perfect example is the ancient Japanese people. What happened when the Westernized diet was introduced? The incidences of baldness skyrocketed.

Another example. Greece is one of the baldest nations. Same with Czech Republic, UK, Spain, and U.S. The one striking commonality I see in such countries is, you named it: Dairy. Greece is know to thrive on dairy. They have tzatzkik sauce, greek yogurt, greek ice cream, feta cheese, etc. I won't be surprised if they bathed in dairy.

Sure there are extreme cases of an obese man having a full head of hair and a vegan man having no hair.

I am not saying diet will regrow hair. What I am saying is diet and stress can cause Androgenetic Alopecia and other forms of hair loss.

It did plain and simple for me. Whey destroyed my life and hair. I am an ideal example of Androgenetic Alopecia kicking in at a young age because of diet-manipulation.

When you extrapolate the ANCIENT Japansese diet, you'll come to find that dairy, grains, and red meat aren't commodities. I like to use them as an example, because they have the longest life spans AND, prior to Westernization, they were almost immune to baldness. Plus, the graying of hair is almost non-existent even at a ripe old age. Doesn't this tell you something?????

They must be doing something right in their lifestyle. Eating smaller portions, lots and lots of iodine, lots and lots of soy.... All these tiny changes accumulate over time and as result, because their androgens are low, they pass these good qualities to their offspring.

So their offspring now has almost Androgenetic Alopecia-proof genes thanks to their parents and grand parents and great grand parents.

Princessrambo (a legend in this forum) was a prime example of someone who went from a Norwood 7 to a Norwood 2 I believe via supplements and minoxidil. But all of us know minoxidil alone cannot restore a Norwood hairline in about 8-12 months.

Meanstick on the bodybuilding forum was also a prime example of reversing his Norwood 2 hairline via supplementation and NO drugs.

I also have some case studies from a well known doctor in India who's currently helping his patients reverse Androgenetic Alopecia via supplementation and a natural peptide cream. His work is patented and he has 25 years of experience and surplus of accolades. If you want more info, I will be more than happy to share his work and comparable before and after pics.

I hated dairy for years and was not eating much/any of it when balding started.

 

[bridgeburn]

DHEA and other adrenal androgens have a 15-30x lower binding affinity than DHT does for the Androgen Receptor.
Testosterone has a 2-3x lower affinity than DHT so its just as bad considering its 10-15x more abundant as an androgen.

DHEA is both an androgen and an estrogen, and supposedly a better agonist of ERb(good for hair) than ERalpha(responsible for gyno). still it might be problematic cause it can metabolize into DHT locally.

Wikipedia:
Though it was found to be a partial agonist of the ERα with a maximal efficacy of 30–70%, the concentrations required for this degree of activation make it unlikely that the activity of DHEA at this receptor is physiologically meaningful. Remarkably however, DHEA acts as a full agonist of the ERβ with a maximal response similar to or actually slightly greater than that of estradiol, and its levels in circulation and local tissues in the human body are high enough to activate the receptor to the same degree as that seen with circulating estradiol levels at somewhat higher than their maximal, non-ovulatory concentrations; indeed, when combined with estradiol with both at levels equivalent to those of their physiological concentrations, overall activation of the ERβ was doubled. As such, it has been proposed that DHEA may be an important and potentially major endogenous estrogen in the body.[10][19]

 

[DHTcel]

DHEA is both an androgen and an estrogen, and supposedly a better agonist of ERb(good for hair) than ERalpha(responsible for gyno). still it might be problematic cause it can metabolize into DHT locally.

Wikipedia:
Though it was found to be a partial agonist of the ERα with a maximal efficacy of 30–70%, the concentrations required for this degree of activation make it unlikely that the activity of DHEA at this receptor is physiologically meaningful. Remarkably however, DHEA acts as a full agonist of the ERβ with a maximal response similar to or actually slightly greater than that of estradiol, and its levels in circulation and local tissues in the human body are high enough to activate the receptor to the same degree as that seen with circulating estradiol levels at somewhat higher than their maximal, non-ovulatory concentrations; indeed, when combined with estradiol with both at levels equivalent to those of their physiological concentrations, overall activation of the ERβ was doubled. As such, it has been proposed that DHEA may be an important and potentially major endogenous estrogen in the body.[10][19]

correct, great find, I doubt DHEA can cause hair loss, its just T and DHT

 

[keepcoolmybabies]

DHEA is both an androgen and an estrogen, and supposedly a better agonist of ERb(good for hair) than ERalpha(responsible for gyno). still it might be problematic cause it can metabolize into DHT locally.

Wikipedia:
Though it was found to be a partial agonist of the ERα with a maximal efficacy of 30–70%, the concentrations required for this degree of activation make it unlikely that the activity of DHEA at this receptor is physiologically meaningful. Remarkably however, DHEA acts as a full agonist of the ERβ with a maximal response similar to or actually slightly greater than that of estradiol, and its levels in circulation and local tissues in the human body are high enough to activate the receptor to the same degree as that seen with circulating estradiol levels at somewhat higher than their maximal, non-ovulatory concentrations; indeed, when combined with estradiol with both at levels equivalent to those of their physiological concentrations, overall activation of the ERβ was doubled. As such, it has been proposed that DHEA may be an important and potentially major endogenous estrogen in the body.[10][19]

I noticed that @likemike had a DHEA supplement listed as a part of his regimen, so perhaps that's the reason?

 

[Ikarus]

LOL I should see if i still have a photo of me when i was having a mental breakdown in 2017, i shaved off all of my hair, eyebrows etc for like 3 months.

 

[bridgeburn]

I noticed that @likemike had a DHEA supplement listed as a part of his regimen, so perhaps that's the reason?

I think its because DHEA is touted as anti-aging

 

[keepcoolmybabies]

View attachment 124953

I was hardly smiling like Britney the first time I took a razor to my head.

 

[bridgeburn]

Lolol okay @bridgeburn, here it is lmfao, the time when i was having mental breakdown in 2017. I legit looked like a cancer patient going through chemo and radiation. My friend sent it to me cause i didn't have it in my phone.

View attachment 124946

bwahhahaahaa, it's more shocking than I expected!

its pretty sad actually f*** hairloss, I'm glad you're here

 

[bridgeburn]

I was hardly smiling like Britney the first time I took a razor to my head.

 

[Ikarus]

me and OP tried the "natural path " before, i used to drink gooseberry juice and smear nettle root and curry every morning but nothing happened plus i would smell like sh*t for few days

I was CONVINCED I had telogen effluvium for months and months... I had this weird mindset of ‘I’m not like others guys, it will grow back ‘ and it never did lmao

 

[bridgeburn]

Tbh i am lucky to be here, i was drinking entire bottles of codeine caugh syrup / nyquill dxm and taking all kinds of excessive amounts of anything that would get me high, to escape my growing insanity, but i am much better today, i am lucky to have survived my suicidal drug abuse phase, f*** hair loss to infiniti and beyond.

:`( god that is depressing.
The world needs to open its eyes to the seriousness of hair loss

 

[bridgeburn]

It's funny how emo and dark this looks, lol. I used to take so many stupid weird pictures of myself years ago and I was so serious >.<
but now I look back and think I was a big grumpy dork

(fake blood, don't ask >.< Lol)

 

[bridgeburn]

" concentrations of PRL, total T, A, DHEA, or DHEA-S. No difference was observed, however, in the induction of these endocrine changes between the Diane and Androcur groups"

So ditto for CPA.

but this is comparing diane and androcur which both have cypro

 

[keepcoolmybabies]

if HRT is a forever treatment for me that works, then that will be just as great lol. okay rant over.

I've wasted so much of my life to hairloss. And every social situation, no matter how much I laughed and smiled, I'd secretly hated because I'd feel that at any moment my hat could get pulled off.

Luckily finesteride helped regain a decent amount of hair and initially some confidence. But when that stopped working everything seemed doomed. Then I stumbled upon this thread a little over a year ago and read the entire thing over night and it was life changing.