Exploring The Hormonal Route. Hair=life.

[DogoDiLaurentiis]

You're right about one thing, it's really not with having a discussion with you about you about this.

Yes because you cannot resort to sophistry and moral grandstanding to get me to agree with you, which is all you have at your disposal.

Thank you for seeing things my way.

 

[keepcoolmybabies]

Yes because you cannot resort to sophistry and moral grandstanding to get me to agree with you, which is all you have at your disposal.

Thank you for seeing things my way.

Because you do none of that. I'm done responding to you though anyway.

Good luck with your regimen.

 

[JaneyElizabeth]

I would call insulin resistance the plague of the 21st century.This is a real plague for sex hormones!The plague of our time!

I am sort of chatting with a Russian man. I love the folks from all over the world who want hair!

 

[DogoDiLaurentiis]

Diverging back to more relevant topics, I have come across this and I'm a bit discouraged as to what steps I should take in order to inhibit the effects of androgens.

Prolonged treatment with bicalutamide induces androgen receptor overexpression and androgen hypersensitivity - PubMed

Bicalutamide-resistant LNCaP-BC2 exhibited AR overexpression and hypersensitivity to low levels of androgen. Our data suggests that AR overexpression is a significant mechanism of bicalutamide resistance similar to resistance from chronic androgen depletion. In addition, pAR(210) overexpression...

pubmed.ncbi.nlm.nih.gov

"Prolonged treatment with bicalutamide induces androgen receptor overexpression and androgen hypersensitivity"

I really do think that because of this potential phenomena, estrogen and estrogen receptor agonists are absolutely necessary to keep hair going.

I still feel I need to get my test levels down, but I just don't know if bica or cyproterone is a better option, I definitely cannot use spironolactone as I already have problems with diuresis because of addison's. I feel like even though it may not make a huge difference I think I may opt for diane35 if only because it contains a small amount of estrogen which will compliment the topical I am applying.

 

[keepcoolmybabies]

Diverging back to more relevant topics, I have come across this and I'm a bit discouraged as to what steps I should take in order to inhibit the effects of androgens.

Prolonged treatment with bicalutamide induces androgen receptor overexpression and androgen hypersensitivity - PubMed

Bicalutamide-resistant LNCaP-BC2 exhibited AR overexpression and hypersensitivity to low levels of androgen. Our data suggests that AR overexpression is a significant mechanism of bicalutamide resistance similar to resistance from chronic androgen depletion. In addition, pAR(210) overexpression...

pubmed.ncbi.nlm.nih.gov

"Prolonged treatment with bicalutamide induces androgen receptor overexpression and androgen hypersensitivity"

I really do think that because of this potential phenomena, estrogen and estrogen receptor agonists are absolutely necessary to keep hair going.

I still feel I need to get my test levels down, but I just don't know if bica or cyproterone is a better option, I definitely cannot use spironolactone as I already have problems with diuresis because of addison's. I feel like even though it may not make a huge difference I think I may opt for diane35 if only because it contains a small amount of estrogen which will compliment the topical I am applying.

Well bica won't technically lower test lvls (only increase them). CPA can suppress T drastically with as little as 12.5mg, if that's indeed your goal.

Diane35's most useful aspect for hair is that it increases shbg rather significantly due to the type of estrogen it contains

 

[Isneezedsohard]

It took me 2 seconds to find those 3 people. I've been active in the community for a while, go to an LGBT center, so I think can offer a bit of empirical observation that your absolutism of ftms isn't being reasonable

What percentage of people on here are transitioning?

 

[keepcoolmybabies]

Also to add, pretty much every AA is linked to androgen hypersensitivity at some point in studies with prostate cancer patients, which is why they keep trying to innovate newer options for castrate resistant prostate cancer. But even daro and enza are a losing battle in those instances too. The biggest variable, though, is the cancer itself and whether or not the same androgen overexpression exists when cancer cells aren't involved. There's a study of finasteride 5 years after usage analyzing AR that suggests it is unfortunately though.

 

[keepcoolmybabies]

What percentage of people on here are transitioning?

No idea. I know of maybe 3 or 4 people altogether, so doubt too many

 

[Gergely]

Diverging back to more relevant topics, I have come across this and I'm a bit discouraged as to what steps I should take in order to inhibit the effects of androgens.

Prolonged treatment with bicalutamide induces androgen receptor overexpression and androgen hypersensitivity - PubMed

Bicalutamide-resistant LNCaP-BC2 exhibited AR overexpression and hypersensitivity to low levels of androgen. Our data suggests that AR overexpression is a significant mechanism of bicalutamide resistance similar to resistance from chronic androgen depletion. In addition, pAR(210) overexpression...

pubmed.ncbi.nlm.nih.gov

"Prolonged treatment with bicalutamide induces androgen receptor overexpression and androgen hypersensitivity"

I really do think that because of this potential phenomena, estrogen and estrogen receptor agonists are absolutely necessary to keep hair going.

I still feel I need to get my test levels down, but I just don't know if bica or cyproterone is a better option, I definitely cannot use spironolactone as I already have problems with diuresis because of addison's. I feel like even though it may not make a huge difference I think I may opt for diane35 if only because it contains a small amount of estrogen which will compliment the topical I am applying.

I really should stop taking bica for that reason, but whos to say lowering androgens in general whoudn't lead to the same fate. I'm about to switch to progesterone and estradiol only.

 

[JaneyElizabeth]

Diverging back to more relevant topics, I have come across this and I'm a bit discouraged as to what steps I should take in order to inhibit the effects of androgens.

Prolonged treatment with bicalutamide induces androgen receptor overexpression and androgen hypersensitivity - PubMed

Bicalutamide-resistant LNCaP-BC2 exhibited AR overexpression and hypersensitivity to low levels of androgen. Our data suggests that AR overexpression is a significant mechanism of bicalutamide resistance similar to resistance from chronic androgen depletion. In addition, pAR(210) overexpression...

pubmed.ncbi.nlm.nih.gov

"Prolonged treatment with bicalutamide induces androgen receptor overexpression and androgen hypersensitivity"

I really do think that because of this potential phenomena, estrogen and estrogen receptor agonists are absolutely necessary to keep hair going.

I still feel I need to get my test levels down, but I just don't know if bica or cyproterone is a better option, I definitely cannot use spironolactone as I already have problems with diuresis because of addison's. I feel like even though it may not make a huge difference I think I may opt for diane35 if only because it contains a small amount of estrogen which will compliment the topical I am applying.

I think XY's often obsess over such decisions. FtM's use one thing. We love to tinker, us Xy's among Mtf's and cis-guys. I spent all this time researching spironolactone and then that was not a good year. Bica is safer so try that.

 

[JaneyElizabeth]

Yeah bica is actually a weak estrogen tbh.

It stops androgen working in your body but raises e2 2× so yeah. I wonder why people cant halt their loss with bica, or even get small regrowth. Bica is far more effective than finasteride+minoxidil tbh. You adress the direct problem and even give a chance to let it regrow (raised e2 levels). Far more effective=far more risks.

But the cool thing about bica is that it wont cause osteoporosis, muscle retention, fat redistribution, ED etc. In theory, you could stay on it for ever and stay freezed in 'before-puberty' mode. The only hurdle is the hepatotoxic feature of it. Hm

Some say less libido diminution but that's a bug versus feature thing. What a relief estrogen is from compulsive stuff guys do.

 

[JaneyElizabeth]

Also to add, pretty much every AA is linked to androgen hypersensitivity at some point in studies with prostate cancer patients, which is why they keep trying to innovate newer options for castrate resistant prostate cancer. But even daro and enza are a losing battle in those instances too. The biggest variable, though, is the cancer itself and whether or not the same androgen overexpression exists when cancer cells isn't involved. There's a study of finasteride 5 years after usage analyzing AR that suggests it is unfortunately though.

Wow! Nicely stated.

 

[JaneyElizabeth]

No idea. I know of maybe 3 or 4 people altogether, so doubt too many

<raises hand>

 

[JaneyElizabeth]

<raises hand>

I swear to Goddess, this is my eight year and I am still getting ahem more fleshy.

 

[Almas]

I think it is safer to add estradiol to Bica than spironolactone. spironolactone seems to have many unpleasant effects.
I wonder if I'm a cis male, would others be suspicious? Or will I still look like a guy without wearing makeup, but with smoother skin? I don’t want others to suspect anything. I am also wondering if I can preserve male breasts if I remove the gland completely

 

[JaneyElizabeth]

I think it is safer to add estradiol to Bica than spironolactone. spironolactone seems to have many unpleasant effects.
I wonder if I'm a cis male, would others be suspicious? Or will I still look like a guy without wearing makeup, but with smoother skin? I don’t want others to suspect anything. I am also wondering if I can preserve male breasts if I remove the gland completely

FWIW. I hear that libido is better on bica, it's better for hair and it has fewer of spironolactone's sides. Only thing is, and it's close, over a lifetime Bica might be more harsh. Bica is also used as a puberty blocker adjunct.

 

[Almas]

I really should stop taking bica for that reason, but whos to say lowering androgens in general whoudn't lead to the same fate. I'm about to switch to progesterone and estradiol only.

It's about the sensitivity of cancer cells to Bicalutamide, but if you don't have cancer, your cells don't mutate. I don't know, I'm not sure if this study applies to us

 

[keepcoolmybabies]

---

It's about the sensitivity of cancer cells to Bicalutamide, but if you don't have cancer, your cells don't mutate. I don't know, I'm not sure if this study applies to us

Not necessarily. Mutation isn't the same thing as receptor sensitivity.

 

[Isneezedsohard]

---

Not necessarily. Mutation isn't the same thing as receptor sensitivity.

Is this for AA's in general? I've read things about finasteride preventing prostate cancer-- but in rare cases, it causes more aggressive prostate cancer.

 

[keepcoolmybabies]

I think it is safer to add estradiol to Bica than spironolactone. spironolactone seems to have many unpleasant effects.
I wonder if I'm a cis male, would others be suspicious? Or will I still look like a guy without wearing makeup, but with smoother skin? I don’t want others to suspect anything. I am also wondering if I can preserve male breasts if I remove the gland completely

A lot of it depends on how you look now in terms of bone structure, etc. There's a decent chance you might just end up looking like a younger guy with nicer skin. But fat redistribution will affect your male attributes in ways that might not be deemed ideal for guys. For instance your jawline will likely soften up and you'll get more cheek fat. And if you don't have especially masculine bone structure as is, then there's a chance you will start looking female given enough time. Personally I didn't feel comfortable presenting female (makeup, clothing, etc) until random strangers began gendering me female while still presenting male. So the possibility to "male fail" exists regardless of presentation in time.