Exploring The Hormonal Route. Hair=life.

[Pls_NW-1]

If it increases estrogen bioavailability, it might help further hair recovery!? Because all the E goes from the breast tissue to the scalp!? Ugh

 

[Gergely]

I actually thought that it's a SERM and has antagonistic features on the breast tissue, thus increasing estrogen bioavailability.

hmm oh well i'm not planning on using it anyways

 

[Pls_NW-1]

why not , but We need to understand that this will always be systematic.

I think it is worth the try, I have seen positive reports of raloxifene, however and this mechanism of action.

Maave used 100mg bica + 60mg raloxifene, no gyno, temple regrowth occured. He dropped ralox after gyno surgery because he doesnt want to use anymore for that meds. Nothing heard anymore from him

-> non binary patient.

 

[tato123]

Maave used 100mg bica + 60mg raloxifene, no gyno, temple regrowth occured. He dropped ralox after gyno surgery because he doesnt want to use anymore for that meds. Nothing heard anymore from him

-> non binary patient.

And I say that raloxifene has a very good liver pass, so it wouldn't overload, but he developed gynecomastia even though he took this dose of raloxifene in bicalutamide? have more information about that?
time he waited to operate and where was he for example

 

[Pls_NW-1]

And I say that raloxifene has a very good liver pass, so it wouldn't overload, but he developed gynecomastia even though he took this dose of raloxifene in bicalutamide? have more information about that?
time he waited to operate and where was he for example

He had sore nipples and started ralox, he said it went a bit away, but then did just surgery and dropped it.

Nothing new anymore. I think he is active on REDDIT. Was around here for a time on gourmetstylewellness.com, back then, with Ikarus, DHTcel and Ein, as the first Bica gen lol.

We are the second gen boyos.lol
I wonder why all of them went away...

 

[tato123]

He had sore nipples and started ralox, he said it went a bit away, but then did just surgery and dropped it.

Nothing new anymore. I think he is active on REDDIT. Was around here for a time on gourmetstylewellness.com, back then, with Ikarus, DHTcel and Ein, as the first Bica gen lol.

We are the second gen boyos.lol
I wonder why all of them went away...

Perhaps they achieved the results

I didn't get it right, he developed gynaecomastia on bicalutamide alone, then held it with ralox until the surgery, is that what happened?

Taking Raloxifene and Bicalutamide will look "like CPA"

You will block all your expression AR and ER

Depression, more erectile dysfunction and how many more things.


Tsc..... The old Greek Hydra

 

[Pls_NW-1]

I didn't get it right, he developed gynaecomastia on bicalutamide alone, then held it with ralox until the surgery, is that what happened?

Yes!

 

[Pls_NW-1]

"Exactly. That's the reason I refrain from using any SERM. There haven't been enough studies to find out whether SERMs have agonizing action of estrogen on hair follicles or antagonizing. And looking at the side effect profiles of Tamoxifene and Raloxifene makes me wanna scream out of horror.
Someone on this forum shared with me a link to an article that stated that some women on Tamoxifene experienced hair loss in female pattern. That was quite convincing to me because hair follicles and breast tissues are both a part of the skin.
Then I did a little research and found out that the receptor-ligand complex that Tamoxifene forms with estrogen receptors of hair follicles are structurally similar to the complexes that estrogens form.
This paradox forced me to back off."

- Ein


Tamoxifene prevented any gyno which could occur by Bicalutamide.

I think SERM's are like playing with fire. Your follicles might suffer from them.

I will try to search some stuff about ralox.

Ein said that gyno surgery should permanently prevent any gyno while on bica.

 

[Norwoody]

My goal is NW8

 

[Pls_NW-1]

My goal is NW8

I love your name, this sentence and your profile picture, just hilarious.

 

[Reciprocity]

Perhaps they achieved the results

I didn't get it right, he developed gynaecomastia on bicalutamide alone, then held it with ralox until the surgery, is that what happened?

Taking Raloxifene and Bicalutamide will look "like CPA"

You will block all your expression AR and ER

Depression, more erectile dysfunction and how many more things.


Tsc..... The old Greek Hydra

From what I understand ralox selectively inhibits a type of estrogen receptor that's mostly present only in breast tissue.

 

[Norwoody]

"Exactly. That's the reason I refrain from using any SERM. There haven't been enough studies to find out whether SERMs have agonizing action of estrogen on hair follicles or antagonizing. And looking at the side effect profiles of Tamoxifene and Raloxifene makes me wanna scream out of horror.
Someone on this forum shared with me a link to an article that stated that some women on Tamoxifene experienced hair loss in female pattern. That was quite convincing to me because hair follicles and breast tissues are both a part of the skin.
Then I did a little research and found out that the receptor-ligand complex that Tamoxifene forms with estrogen receptors of hair follicles are structurally similar to the complexes that estrogens form.
This paradox forced me to back off."

- Ein


Tamoxifene prevented any gyno which could occur by Bicalutamide.

I think SERM's are like playing with fire. Your follicles might suffer from them.

I will try to search some stuff about ralox.

Ein said that gyno surgery should permanently prevent any gyno while on bica.

Yeah if you're gonna do SERMs you might as well do SARMs or steroids lol

 

[Norwoody]

I love your name, this sentence and your profile picture, just hilarious.

Love you too? ;*

 

[tato123]

From what I understand ralox selectively inhibits a type of estrogen receptor that's mostly present only in breast tissue.

I want you to note that nothing is selective like that, although perhaps it has a greater selectivity in comparison with its analogous brothers like tamoxifen its use is systematic, your whole body has this type of receptor, I do not believe it will act only there strongly that it does not.

 

[Pls_NW-1]

From what I understand ralox selectively inhibits a type of estrogen receptor that's mostly present only in breast tissue.

No they modulate every estrogen receptor. They antagonize some, and agonize some. The mechanism on the hair follicle on scalp is unknown. Thats why they are called SERM's modulating ER's.

In breast tissue, they antagonize.

 

[tato123]

But opinions are contradictory, there are people who say they keep it with raloxifene, I tell you this is biological individuality, it causes depression because the ER expression in our brain is also impaired, I don't see why it would prevent attack the hair follicle.

 

[Pls_NW-1]

"Irrespective of that, the action of Raloxifene on hair is still unknown. And even if it doesn't affect hair growth, a healthy lipid profile and bone density is still important. NSAAs, in my opinion, make the body form healthy estrogen levels to regulate the HPG axis, since androgens are pretty much useless in the body. So, taking NSAAs(Bicalutamide) and SERMs(Raloxifene) together is not very appealing."

- Ein

I just love Ein lol

 

[tato123]

"Irrespective of that, the action of Raloxifene on hair is still unknown. And even if it doesn't affect hair growth, a healthy lipid profile and bone density is still important. NSAAs, in my opinion, make the body form healthy estrogen levels to regulate the HPG axis, since androgens are pretty much useless in the body. So, taking NSAAs(Bicalutamide) and SERMs(Raloxifene) together is not very appealing."

- Ein

I just love Ein lol

This guy's head works like mine

 

[Pls_NW-1]

"The possibility exists. Hair thinning is a documented side effect of SERMs, but the area of the body isn't mentioned. There are anecdotal reports of hair thinning in scalp from use of SERMs, but like I said, the ligand-receptor complex theory also exists. But binding to the correct receptor isn't the last step. The type of transcriptional regulation generated is also important. Even if the receptor is ER beta in hair follicles of scalp, there is a possibility that SERMs transcripts corepressors instead of coactivators (like Bicalutamide's action on androgen receptors) or they do nothing but block the position that needs to be occupied by estrogen molecules (like Cyproterone Acetate's action on androgen receptors). SERMs are pure enigma."

Hope this clarifies something for you guys!

Better stay off meds for gyno and just do surgery... I still try to find prostate cancer patients who did surgeries. Gotta keep u all updated, on the milky way lol

 

[tato123]

We are getting somewhere here, we have a lot of knowledge in this topic my god

You could make an e-book with it here.

in other words guys

Avoid bicalutamide + raloxifene and tamoxifen toghether

Suppressed AR and ER is not good