Exploring The Hormonal Route. Hair=life.

[tato123]

ClinicalKey

www.clinicalkey.com

""By day 4, control HFs and HFs treated with DHT plus bicalutamide were still in anagen, whereas HFs treated with DHT alone had entered catagen phase. Hair length recording revealed that DHT inhibited hair growth and that this effect was partly reversed by bicalutamide""

Very good @Almas article, I had never seen anything from specific bicalutamide treating androgenic alopecia in that sense DHT

Only studies in women

Good article.

 

[tato123]

@tato123 Heya!

So, in your opinion, does this mean you can't take Metformin for live?

What would you consider as a long term risk for Metformin?

Nice posts!!!

I think that this needs studies.

Since patients who have diabetes can be a normal complication the kidneys do not function properly, so there are not many studies in this regard in the long term as the kidneys are affected by the underlying disease that the drug is used to treat.

I think this pathway interferes with a very dangerous pathway in our body, but it is a medication widely used worldwide.

But like all drugs, think about whether you are willing to take that risk.

I'm not going to give my opinion openly like this anymore, a lot of people visit this topic and read loose things, I don't want to influence anyone at all, I made available all the content I got, I want everyone to read and put it on the scale if they are willing to take the risks or not, since nothing can happen, or it can happen, as well as any treatment.

See that metformin was as effective as finasteride in treating various conditions.

It works!

And so ? Are you going to sign the contract?

COMPARISON OF FINASTERIDE, METFORMIN, AND FINASTERIDE PLUS METFORMIN IN PCOS - PMC

The effects of finasteride on insulin resistance and of metformin on hyperandrogenism in patients with polycystic ovary syndrome (PCOS) are not clear. This study therefore compared the effects of finasteride, metformin, and finasteride plus ...

www.ncbi.nlm.nih.gov

 

[Almas]

Bicalutamide has shown excellent results in mice. It should be borne in mind that in combination with a 5AR blocker, Bicalutamide shows the best results, that is, a complete cure is possible if you started treatment on time. I do not know what dose was used in the study in terms of human equivalent, the appropriate dose in combination with a 5AP blocker I have to find empirically, doing research on myself
This dosage is somewhere in the 50-100mg range.

 

[John Difool]

Flashback from the past:

https://www.gourmetstylewellness.com/interact/threads/safest-antiandrogen-for-your-dick-bicalutamide.123190/page-5#dat-menu

 

[John Difool]

Bicalutamide dosage is 1mg per 4 ng/dL of T. However binding affinity of Bica to AR is lower than T and of course DHT. But it will work somewhat by flooding the AR 5000 times to 1. You still need a 5ARI like Duta to block T from converting to DHT or even higher dose of Bica (as DHTCel did but not advised because drug can be hard on liver.) You won't lower your T with Bica. It stays in the blood serum and doesn't bind. It could even increase due to feedback loop (the formula above takes that into consideration). To lower T you need E2. Then feedback loop will create even more E2 with T conversation to E2 (thankfully the opposite doesn't happen). Increasing E2 will at some point lower your T so much that Bica is not necessary as you are approaching female range. If you suffer male pattern baldness keep using Duta to cut DHT but at lower T you can start adding longer cycles. At this point you are on HRT just because you have hairloss dysphoria which won't be ideal in society if you don't embrace the sides as your new lifestyle.

PS: don't even think about lowering your T and keeping your E low unless you want to live like a zombie. You need one dominant sex hormone in your body. And don't nuke your T entirely. It's still needed for many functions.

PSS: the biggest miss from all these posts is to learn that bridgeburn, ikarus, @Itsnoahkennedy and others haven't bothered to track their progress and associate it with lab work. Doing HRT without blood levels is like playing minigolf blind folded. All they did was using the mirror to experience their progress. This individualistic method doesn't work well for people to try emulating the journey.

 

[WindR]

MPMD guy mentioned progesterone among his blown-up list of supplements.
Progesterone (8 mg before bed; will up the dose; not recommended for naturals)

 

[Pls_NW-1]

Just amazing! This is all summarized very well from the past threads, thank you!

 

[Pls_NW-1]

I see Bicalutamide as a safe medicine as well, besides the possible liver damage and making you look neotenice. The liver issues are inevitable, so it would be great avoiding too many drugs, especially if you want to stay on them for the long term.

 

[Almas]

PSS: the biggest miss from all these posts is to learn that bridgeburn, ikarus, @Itsnoahkennedy and others haven't bothered to track their progress and associate it with lab work. Doing HRT without blood levels is like playing minigolf blind folded. All they did was using the mirror to experience their progress. This individualistic method doesn't work well for people to try emulating the journey.

Agree with you. However, Ikarus followed his analyzes, as did DHTCEL. Ikarus had female hormone levels.

Bicalutamide dosage is 1mg per 4 ng/dL of T.

10ng/dl
It is also not a fact that we necessarily need to completely block the receptors. Ein somehow got the result on a low dose of Bicalutamide, which suggests that we are wrong in the theoretical calculations. There are also factors such as T concentration in different tissues, which we do not know. Therefore, it remains only to empirically look for the right dosage, I am doing this right now. I also know someone who got 75mg Bica, even though his T was 1150 ng / dl. That is why I assume that dosages from 100mg are unnecessary, and 50-75 are enough to block T in the skin.

 

[Pls_NW-1]

That is why I assume that dosages from 100mg are unnecessary

I start to more and more agree on your statement. I think 75mg is sufficient enough, yes.

I will probably start off with 75mg and if needed to 100mg. I will let the 75mg do its' job for 6months then.

 

[John Difool]

I would advise for bioidentical p4 instead. However the half life is short and best administration is rectal.

 

[John Difool]

Agree with you. However, Ikarus followed his analyzes, as did DHTCEL. Ikarus had female hormone levels.

No one shared their lab work. Thanks for all the fish ladies.

10ng/dl
It is also not a fact that we necessarily need to completely block the receptors. Ein somehow got the result on a low dose of Bicalutamide, which suggests that we are wrong in the theoretical calculations. There are also factors such as T concentration in different tissues, which we do not know. Therefore, it remains only to empirically look for the right dosage, I am doing this right now. I also know someone who got 75mg Bica, even though his T was 1150 ng / dl. That is why I assume that dosages from 100mg are unnecessary, and 50-75 are enough to block T in the skin.

If you admit that we are wrong in theorical calculations then I guess there is no point correcting me about the calculation.

Anyway, it all depends and everyone is different. Some mtf patients still lose their hair even after orectomy. There are more than one path to get DHT production than just gonads. Bica can always help but to some extent Some ladies experience remasculanisation. So it's not a done deal. It would be interesting to hear from the ones that have recovered what has happened overtime.

 

[Almas]

If you admit that we are wrong in theorical calculations then I guess there is no point correcting me about the calculation.

I have corrected you in the dosage calculation to completely stop the activation of the AR receptor in the prostate. But he added that it is not a fact that the same dose is needed for the scalp

Anyway, it all depends and everyone is different. Some mtf patients still lose their hair even after orectomy

Yes, there are cases when there is no way out other than a complete trans transition (. I hope this is not about me

 

[Almas]

I finally got rid of the blackheads on my nose. Bicalutamide reduces pores and oil production, it is comfortable

This suggests that it worked well on the face and scalp. I wonder how the follicles will react to this. Look forward to

 

[Pls_NW-1]

No one shared their lab work. Thanks for all the fish ladies.

If you admit that we are wrong in theorical calculations then I guess there is no point correcting me about the calculation.

Anyway, it all depends and everyone is different. Some mtf patients still lose their hair even after orectomy. There are more than one path to get DHT production than just gonads. Bica can always help but to some extent Some ladies experience remasculanisation. So it's not a done deal. It would be interesting to hear from the ones that have recovered what has happened overtime.

On reddit, transtimelines, I read that DHT gets formed through 3 (/4 pathways), and sometimes... the other pathways tank the lost DHT (through the adrenal androgens and other precursors (DHEA-S, P, T (gonadal) and T (from DHEA-S (adrenal))).

I have problems with my adrenal gland and I just HOPE Bicalutamide will work for me, if not, then I am done lol. I will try using Resveratrol and maybe Metformin.

 

[Norwoody]

A while ago, did someone say that bicalutamide and dutasteride have an interaction? Can someone explain this?

 

[Pls_NW-1]

It's counter productive to take them together, Bicaludamide and avodart inhibit the metabolism of progesterone including progestins like CPA, all three drugs are extensively metabolized by the CYP3A4 enzyme. Bicaludamide has been shown to inhibit CYP3A4 in preclinical trials, but no recorded evidence of Bicaludamide inhibiting CYP3A4 is shown, so it may or may not inhibit CYP3A4 in humans. But still Bicaludamide and Dutasteride both inhibit the metabolism of CPA and progesterone, I need CPA, it's effects are more along the lines of what i desire. I may slowly transition from CPA to bio-identical micronized progesterone (Prometrium) as my testosterone blocker, because it's as effective as CPA and lowers LH and FSH without the Brain tumor risk that CPA carries, even though Prometriums side effects list is much longer. The only thing ive noticed from Prometrium is better, longer, deeper sleep, and I'm more hostile, moody but not in a way that makes me feel bad it's more like I'm just, meaner lol.

.

 

[John Difool]

I have corrected you in the dosage calculation to completely stop the activation of the AR receptor in the prostate. But he added that it is not a fact that the same dose is needed for the scalp

Yes, there are cases when there is no way out other than a complete trans transition (. I hope this is not about me

That is not even a way to tell that's a cure. Gonadal pathway is one source of androgen production.

 

[Pls_NW-1]

A while ago, did someone say that bicalutamide and dutasteride have an interaction? Can someone explain this?

I can't find the quotation a member made back then, but it's better using Finasteride, what I gathered from a few users. Tho nobody here's a doctor lmfao.

 

[John Difool]

Bica & Duta have two different mechanisms. One can complement the other for folks with male pattern baldness.