Exploring The Hormonal Route. Hair=life.

[Pls_NW-1]

Anti Androgens are taxing to the liver and may cause damage when used for long periods of time. Using suppositories bypasses the liver, and also achieves total bioavailability. For long term usage it may be beneficial to use these drugs as a suppository. I'm worried about the health of my liver as I'm constantly thirsty, even more so on days when I take meds, does anyone know if bicalutamide/finasteride/dutasteide would work as a suppository?

From my knowledge it needs to pass the liver/digestive system to make it work, ie. Spironolactone. We actually as well dont know if Bicalutamide's metabolites are active, it's unknown. More so it's molecule size is small, so it gets into the blood stream, even if you apply it to the skin, I think pushing it into your *** makes no difference lol. But anyways thats just all broscience.

And yes! Anti androgens are unhealthy!!! The healthiest is Estrogen, in the end.

 

[tato123]

Quando parei a TRH, tudo voltou ao normal.

Progesterone 100mg would probably be really beneficial combined with dutasteride 0.5mg, those 2 might even be enough for regrowth on its own, I’ll try that combo next time if i start balding again.

Hello

First of all I would like to thank you, your solid results and your courage to show and share with us step by step of your treatment from the beginning in the public forum are of an invaluable wealth for this community.

Can I ask you some questions?
They will add a lot to my search

How did you feel after the withdrawal of E2?

I read a lot about behavior change in long HRT therapies

As I understand it, you are in maintenance today with dutasteride.

How do you say your feelings are today? in relation to you, your life, and your result?

Would you say that your sexual side today is the same?

What would you say about Progesterone's inhibitory effect on aromatase?

I know a little about the mechanism of action of progesterone in the body, do you think it helps?
I think that sometimes it is contradictory and you can’t know because normally progesterone treatment is complete MTF, I think a complete treatment would work.

Progesterone + Estrogen + AA.

But that would be a complete MTF treatment

I don't know if randomly added progesterone could help with treatment

And lastly with your knowledge today which scheme would you adopt for a hair loss?

Bicalutamide or CPA?

Bicalutamide alone?
With e2?

CPA + E2?

You used the 2, your opinion will be valuable.

Thanks

 

[franzliszt]

If the medicine is intended for oral use then you need to apply it orally

It's worth a consideration, for those who need to keep taking anti androgens for life to maintain.

from my knowledge it needs to pass the liver/digestive system to make it work, ie. Spironolactone.

Bicalutamide has no known active metabolites, and is reportedly effective effective as a topical anti androgen. Can hard pills such as casodex pills break down when used as a suppository? I can't seem to find any info. Dutasteride should work though, it's a soft capsule, with two less potent active metabolites. It's also effective as a scalp hair loss topical, but with it's large molecular size may have difficulty absorbing through the rectum. But like you said, this is all speculation. I'll give i a try and update the thread if it seems to work.

 

[Pls_NW-1]

Noah, sorry for being again so intrusive, but are you back there where you were before you started HRT, besides having hair again!?

Can you actually do a creampie (again)? Lmfao

 

[Pls_NW-1]

Yes lol

This is just cheating... wtf.

 

[telogen]

I am not sure how E3 works. After researching stuff n' experiences on this forum, it is better using E2.

But as long as my T levels stay inside the reference area that indicate the E3 isn't damaging my nuts?

 

[Almas]

Biohacking we deserve
I would stay on Bicalutamide to minimize the risk of relapse by 100%. Bonus - the oily skin does not return

 

[Pls_NW-1]

But as long as my T levels stay inside the reference area that indicate the E3 isn't damaging my nuts?

Yes, pretty much, but don't forgot; nobody on here is a doctor, all here is pure BroScience...

 

[Pls_NW-1]

Biohacking we deserve
I would stay on Bicalutamide to minimize the risk of relapse by 100%. Bonus - the oily skin does not return

Literally, same. Bica+duta should be considered as nuclear maintenance. +gyno surgery lmfao

 

[Almas]

If I want to temporarily switch to HRT mode, I will try Bicalutamide 75mg + 1.5mg E (2 pump presses) from Estrogel. I wonder what hormone levels can be achieved with this regimen, and how it will help hair.
@Itsnoahkennedy , what do you think about it?

 

[Norwoody]

Noah, sorry for being again so intrusive, but are you back there where you were before you started HRT, besides having hair again!?

Can you actually do a creampie (again)? Lmfao

I'm getting hungry

 

[Norwoody]

I’ve seen many threads on female pattern hairloss websites where women used 50mg Bicalutamide and got all their hair back. So as long as you have E2 you’re good.

What if you're a poor aromatizer?

 

[Pls_NW-1]

How can you know that you are a great aromatizer before starting treatment, lol?

 

[JaneyElizabeth]

Gyno surgery is highly recommended before boobs grow too big if you don’t want to have post-surgery scars.

Yeah, that ship done sailed. Reductions might still work. I have either proven that breast growth is manipulable or I am one in a thousand cause my breasts keep getting bigger and rounder as I attempt to emulate the hormonal profile of a pregnant female. It's worked great hair-wise and well, in the words of @bridgeburn, who doesn't like a nice pair of tits....

 

[JaneyElizabeth]

How can you know that you are a great aromatizer before starting treatment, lol?

Just take a whiff of yourself? Can you smell the T's' aroma as it is transferred into E2?

 

[Norwoody]

How can you know that you are a great aromatizer before starting treatment, lol?

There's probably some kind of T/DHT/E ratios that could show it

 

[Pls_NW-1]

Personally, I dont have a strong smell. I never sweat, only when doing excessive sport lol.

 

[Pls_NW-1]

There's probably some kind of T/DHT/E ratios that could show it

My E is pretty high when comparing to my T. T is barebone low and E2 skyhigh, in terms of normal ranges. It is clearly visible when you look at me #femboy. Soon #temboy.

 

[Norwoody]

My E is pretty high when comparing to my T. T is barebone low and E2 skyhigh, in terms of normal ranges. It is clearly visible when you look at me #femboy. Soon #temboy.

That's a really good sign for you then. Bica should do the job

 

[Almas]

Gyno surgery is highly recommended before boobs grow too big if you don’t want to have post-surgery scars.

Yes, that's what I talked about earlier. I will remove the minor gynecomastia that I get on Bicalutamide monotherapy. After that I will be able to do whatever I want and not be afraid of breast growth.

I’ve seen many threads on female pattern hairloss websites where women used 50mg Bicalutamide and got all their hair back. So as long as you have E2 you’re good.

I wonder if 2 clicks of Estrogel, i.e. 1.5mg E, are enough for a significant result. This is a small dose