Exploring The Hormonal Route. Hair=life.

[Ikarus]

Yes, about those three ways:

1. The blockade of receptors is in no way comparable to that of bicalutamide. It is a steroidal selective androgen receptor antagonist. It works only by reducing the concentration of testosterone so that kinetics don't mess up with its binding. That's why it works only in people with female hormone ranges.
2. The testosterone levels are lowered only when it is already very low and in female ranges, because it can't mess with HPG axis. Therefore, it works only with sufficient levels of estradiol, otherwise good bye to bone density and energy.
3. Yes, it binds to estrogen receptors, but has no estrogenic effects in cells other than osteoblasts and hypothalamus.

Bicalutamide, on the other hand, makes all of the androgens useless and shifts the entire equilibrium to estrogenic support.
Spironolactone, can get easily replaced by androgens when used without estrogens to shift the equilibrium.

How much T does bicalutamide block? There appears to be so many different opinions on this...

 

[Ein]

How much T does bicalutamide block? There appears to be so many different opinions on this...

It varies depending upon what area you're talking about.
50mg/day can block almost all of it (>93%) in the skin and hair. But the same blocks around 0% receptors on the gonads.

 

[coco_304]

Inhousepharmacy.vu use E-check as payment

More options?

 

[Ikarus]

It varies depending upon what area you're talking about.
50mg/day can block almost all of it (>93%) in the skin and hair. But the same blocks around 0% receptors on the gonads.

So, 50mg/day is enough for hair loss and acne? DHTcel explained that 50mg blocks 500 ng/dL of T, but other people say other things... It's quite confusing!

 

[I'mme]

So, 50mg/day is enough for hair loss and acne? DHTcel explained that 50mg blocks 500 ng/dL of T, but other people say other things... It's quite confusing!

That only when increase in T is permanent. Moreover you don't want it to block T there in gonads as Ein said.

 

[I'mme]

Yes, about those three ways:

1. The blockade of receptors is in no way comparable to that of bicalutamide. It is a steroidal selective androgen receptor antagonist. It works only by reducing the concentration of testosterone so that kinetics don't mess up with its binding. That's why it works only in people with female hormone ranges.
2. The testosterone levels are lowered only when it is already very low and in female ranges, because it can't mess with HPG axis. Therefore, it works only with sufficient levels of estradiol, otherwise good bye to bone density and energy.
3. Yes, it binds to estrogen receptors, but has no estrogenic effects in cells other than osteoblasts and hypothalamus.

Bicalutamide, on the other hand, makes all of the androgens useless and shifts the entire equilibrium to estrogenic support.
Spironolactone, can get easily replaced by androgens when used without estrogens to shift the equilibrium.

Darling, what is this! Why are you comparing tmit to bicalutamide? I have always held that Bicalutamide is superior of all. In fact, new 2nd/3rd (don't remember) NSAA are more messy than bicalutamide. I was simply saying that Spironolactone effects are underestimated time and again. It sure has fuckin off-target effects, but for us males who want to remain males, it does the job. If ever I wunt have problem with feminization, I would simply opt for Bicalutamide.

Thanks anyway - you inspire me to do deep researches, but I'm pursuing CA which is one of the most crappiest designed course, takes lots of time, and return have not been good recently. Had I not opted for it, I could have spent my time doing sth else. But my fascination of money...!

 

[I'mme]

So, 50mg/day is enough for hair loss and acne? DHTcel explained that 50mg blocks 500 ng/dL of T, but other people say other things... It's quite confusing!

DHTcel is doing what Itchymadsclap did: not giving treatments enough time and continously tinkering with them.

 

[Yar]

You will regret using spironolactone...

I will not use one spironolactone, only combined with progesterone and estradiol. See the video above.

 

[keepcoolmybabies]

I would ponder on other points later - when I get time, but that spironolactone is a weak anti-androgen is simply a myth. If somebody take say 50mg then yes it is in most cases.
It works in three ways - blocks receptors just like Bicalutamide, reduces testosterone (in most cases), has estrogenic effects (which can be pretty potent at higher dosages. Note however that a higher dose may not works at all and/or may have opposite effect. Taker of this medicine has to know what s/he want with it and adjust accordingly).

I've seen so much conflicting info in regards to whether spironolactone can or can't lower T levels, including multiple studies. The initial study that is used as the basis for why it's included in transgender HRT regimens was conducted in the late 80's. It concluded that spironolactone + E had a bigger impact on bringing T levels to female ranges than E alone. The biggest flaw with the study, however, is that it didn't account for the fact that participants were concurrently using medroxyprogesterone, which a more recent study has concluded was the biggest reason for the difference in T levels.

Speaking from personal experience, however, I've been on a combo of spironolactone and E for about 10 months. The first couple months I was at 4mg E and 100mg spironolactone. Blood tests then showed my T at 40ng/ml. I then upped dosages to 6mg E and 150mg spironolactone and T fell to 15ng/ml. Since then i've switched to estradiol injections and lowered my spironolactone dosage to 100mg and my T ranges between 12 to 16ng/ml. Injections are known to substantially lower T levels, but not so much sublingual unless it's at extreme dosages. My E level on sublingual pills never went above 140pg/ml, however, so I'm not sure if that's sufficient enough to completely quash T to the levels I've experienced. Thus I'm not entirely sure if spironolactone has contributed to the low T levels, but it seems likely.

 

[I'mme]

I've seen so much conflicting info in regards to whether spironolactone can or can't lower T levels, including multiple studies. The initial study that is used as the basis for why it's included in transgender HRT regimens was conducted in the late 80's. It concluded that spironolactone + E had a bigger impact on bringing T levels to female ranges than E alone. The biggest flaw with the study, however, is that it didn't account for the fact that participants were concurrently using medroxyprogesterone, which a more recent study has concluded was the biggest reason for the difference in T levels.

Speaking from personal experience, however, I've been on a combo of spironolactone and E for about 10 months. The first couple months I was at 4mg E and 100mg spironolactone. Blood tests then showed my T at 40ng/ml. I then upped dosages to 6mg E and 150mg spironolactone and T fell to 15ng/ml. Since then i've switched to estradiol injections and lowered my spironolactone dosage to 100mg and my T ranges between 12 to 16ng/ml. Injections are known to substantially lower T levels, but not so much sublingual unless it's at extreme dosages. My E level on sublingual pills never went above 140pg/ml, however, so I'm not sure if that's sufficient enough to completely quash T to the levels I've experienced. Thus I'm not entirely sure if spironolactone has contributed to the low T levels, but it seems likely.

Agree w everything you say. It increases T in some people because they use it with combo "finasteride + dutasteride" or w finasteride or dutasteride. Now both decreases activity of 5ar. Now spironolactone also decreases 5-alpha reductase activity via increased clearance of testosterone secondary to augmented liver hydroxylase activity. This way they increase way too much T and spironolactone AA effects becomes weaker. There are couple of other factors as well.
But please don't take anything I say as full truth - I'm still researching on it. I was just stating that it is not as bad as people make it out to be.

 

[I'mme]

I've seen so much conflicting info in regards to whether spironolactone can or can't lower T levels, including multiple studies. The initial study that is used as the basis for why it's included in transgender HRT regimens was conducted in the late 80's. It concluded that spironolactone + E had a bigger impact on bringing T levels to female ranges than E alone. The biggest flaw with the study, however, is that it didn't account for the fact that participants were concurrently using medroxyprogesterone, which a more recent study has concluded was the biggest reason for the difference in T levels.

Speaking from personal experience, however, I've been on a combo of spironolactone and E for about 10 months. The first couple months I was at 4mg E and 100mg spironolactone. Blood tests then showed my T at 40ng/ml. I then upped dosages to 6mg E and 150mg spironolactone and T fell to 15ng/ml. Since then i've switched to estradiol injections and lowered my spironolactone dosage to 100mg and my T ranges between 12 to 16ng/ml. Injections are known to substantially lower T levels, but not so much sublingual unless it's at extreme dosages. My E level on sublingual pills never went above 140pg/ml, however, so I'm not sure if that's sufficient enough to completely quash T to the levels I've experienced. Thus I'm not entirely sure if spironolactone has contributed to the low T levels, but it seems likely.

If you notice very few people has taken oral Spironolactone 200 mg for more than 6 months and it has worked for all of them.
It effectiveness was less seen by @Father_of_Shiseido because he was using it with 2.5mg Duta, which is an insane dose.

 

[I'mme]

Guys I'm getting flacky skin (kinda peeling) from use of tretinoin, is that normal? It is like flakes we get from scalp stimes.

 

[Ikarus]

Guys I'm getting flacky skin (kinda peeling) from use of tretinoin, is that normal? It is like flakes we get from scalp stimes.

Do you use it on your face?

 

[I'mme]

Do you use it on your face?

Yes.

 

[I'mme]

0.05 concentration

 

[Ikarus]

Yes.

If you are using it on your face and you are experiencing what you are experiencing, that means you are using it too often. Tretinoin is meant to train your skin to behave; peeling and flakey skin isn’t skin which is behaving. How often do you use it?

 

[I'mme]

If you are using it on your face and you are experiencing what you are experiencing, that means you are using it too often. Tretinoin is meant to train your skin to behave; peeling and flakey skin isn’t skin which is behaving. How often do you use it?

Started 3 days before. Actually, it is with hydroquinone and a steroid. I bought this cream to treat a small sign where I had brown skin. But since It has retain A, started applying in on face.

 

[Ikarus]

Started 3 days before. Actually, it is with hydroquinone and a steroid. I bought this cream to treat a small sign where I had brown skin. But since It has retain A, started applying in on face.

Don't use that on your face... That's such a powerful trio to use on your face!

 

[itchymadscalp]

DHTcel is doing what Itchymadsclap did: not giving treatments enough time and continously tinkering with them.

I've been on strong AA for 2.5 years ... and I lost 70% of my hair on the top, and I will remain on Lupron + Estradiol for at least 3 years.
I should give up, because I know it's useless but I cannot accept it. You cannot say I don't give my treatments enough time, even doctors told me to stop so many times.

 

[Yar]

@Ein is it pointless to take dutasteride with bicalutamide/cyproterone acetate and estrogen? do i need dutasteride to get the full effect of this therapy, if i do need it, then i will order a years supply of it tonight.

dutasterid and what is it for you if it increases testosterone?