Exploring The Hormonal Route. Hair=life.

[Ikarus]

I've got no idea. I mean I think hairloss should be considered just as worthy a dysphoria for these meds, but it would be completely up to the discretion of the doctor. I told my Doctor I had gender issues. But obviously tell them whatever you are comfortable with. You can always order meds online like multiple people here do and then see a Doctor for blood tests if need be.

That's what I might do... I visit my endocrinologist soon, and I think it's best for me to just tell him I suffer with gender dysphoria. It would be easier for myself in the long-run, and it would be safer for myself in the long-run. I'm not sure how the process is, if he deals with it or if he refers me to a gender specialist but I believe it will be a difficult process...

 

[baba_yaga]

I will never watch Vsauce the same way I did before.

 

[itchymadscalp]

It seems that I'm the only on who's unlucky with his HRT regimen ... that sucks. I mean that's nice if there is no other guys with the same issues, but ... that sucks anyway.

Sometimes I think I should be hit by the thunderbolt, not to get some superpowers, but to repair my DNA (it doesn't make sense in reality, only in comics, no?), so AA+E could finally work.
If you have other ideas, maybe safer, I would love to take them in consideration.

 

[bridgeburn]

It seems that I'm the only on who's unlucky with his HRT regimen ... that sucks. I mean that's nice if there is no other guys with the same issues, but ... that sucks anyway.

Sometimes I think I should be hit by the thunderbolt, not to get some superpowers, but to repair my DNA (it doesn't make sense in reality, only in comics, no?), so AA+E could finally work.
If you have other ideas, maybe safer, I would love to take them in consideration.

maybe you should switch to bicalutimide again, but stay on it longer.. Because it has some special corepressor sciency function that Ein ws talking about

 

[Sonolmn98]

If anyone knows, i stopped minoxidil 3.5 months ago. It has made hair grow on my back, neck, nose, ears, and under my lower eye lids (looks like my beard grows up to my eyeballs now) its been 3.5 months without minoxidil and they are not getting smaller, are these permanent? Or how long do you think it will take for them to go away?

the hairs should be dependent and weak, as long as your androgens are under check then dnt worry as dht causes ear, nose, beard hair regrowth it is the ugly hormone the transforms a juvenile angel into an ork, drop the mino and block T and give it time, it should be reversed

 

[I'mme]

It seems that I'm the only on who's unlucky with his HRT regimen ... that sucks. I mean that's nice if there is no other guys with the same issues, but ... that sucks anyway.

Sometimes I think I should be hit by the thunderbolt, not to get some superpowers, but to repair my DNA (it doesn't make sense in reality, only in comics, no?), so AA+E could finally work.
If you have other ideas, maybe safer, I would love to take them in consideration.

Increase in prolactin has been found to cause hyperandrogenity, Iirc. But that's in prostate cancer guys

 

[Sonolmn98]

Increase in prolactin has been found to cause hyperandrogenity, Iirc. But that's in prostate cancer guys

we know that many types of anti androgens can cause elevated prolactin as a side effects, and eunuchs were shown to have low prolactin and high progesterone levels naturally, thats why surgical castration is used for prostate cancer patients who arent responding to AA and have hyperandrogenity from elevated prolactin

 

[I'mme]

we know that many types of anti androgens can cause elevated prolactin as a side effects, and eunuchs were shown to have low prolactin and high progesterone levels naturally, thats why surgical castration is used for prostate cancer patients who arent responding to AA and have hyperandrogenity from elevated prolactin

Spironolactone decrease prolactin prod and its levels. But yeah most AA increase it. We can also extrapolate that prolactin may not be directly causing hairloss (hair loss) but it does by making us more sensitive to androgens.
One thing I don't understand is that some people see continuation of p cancer even after been surgically castrated.

 

[bridgeburn]

Increase in prolactin has been found to cause hyperandrogenity, Iirc. But that's in prostate cancer guys

we know that many types of anti androgens can cause elevated prolactin as a side effects, and eunuchs were shown to have low prolactin and high progesterone levels naturally, thats why surgical castration is used for prostate cancer patients who arent responding to AA and have hyperandrogenity from elevated prolactin

prolactin lowers SHBG

 

[I'mme]

prolactin lowers SHBG

You mean higher prolactin lowers Shbg? Otherwise it doesn't make sense as spironolactone decreases prolactin but also increases Shbg levels.

 

[Sonolmn98]

Spironolactone decrease prolactin prod and its levels. But yeah most AA increase it. We can also extrapolate that prolactin may not be directly causing hairloss (hair loss) but it does by making us more sensitive to androgens.
One thing I don't understand is that some people see continuation of p cancer even after been surgically castrated.

if the spread of cancer doesn't stop after orchiectomy then they will add back the anti androgens, but stopping and anti androgens all the sudden will cause hyperandrognity in some people even if they are castrated, so they mind need both orchectomy, an AA and estrogen to be safe but it is rare

 

[bridgeburn]

You mean higher prolactin lowers Shbg? Otherwise it doesn't make sense as spironolactone decreases prolactin but also increases Shbg levels.

estrogen also increases prolactin, however estrogen itself increases SHBG. the SHBG increase effect is greater than the SHBG lowering affect of the amount of prolctin estrogen increases

 

[bridgeburn]

SHBG prefers to bind to DHT over T and T over E which is great!

However, it also has greater affinity for Estradiol than Estrone therefore, if we have Zero androgens then elevated SHBG could shift the E1/E2 ratio more towards the E1 side (not good)

 

[bridgeburn]

prolactin is elevated for about 1 hour after orgasm (perhaps this could make women more estrogenic and men more androgenic?) *If they aren't on hrt or hormonally altered i mean

 

[Sonolmn98]

SHBG prefers to bind to DHT over T and T over E which is great!

However, it also has greater affinity for Estradiol than Estrone therefore, if we have Zero androgens then elevated SHBG could shift the E1/E2 ratio more towards the E1 side (not good)

so we need some androgens to get results? so the shgb wont bind to E2

 

[DHTcel]

maybe you should switch to bicalutimide again, but stay on it longer.. Because it has some special corepressor sciency function that Ein ws talking about

yes, bica reduces ARE(androgen response element) mechanism's of action over time

thats why after 3 months Bica reduced PSA by 86-94% and after 1 year it reduces PSA by +97%

https://www.ncbi.nlm.nih.gov/pubmed/21466228

 

[bridgeburn]

so we need some androgens to get results? so the shgb wont bind to E2

either that or have more orgasms

 

[bridgeburn]

The relative binding affinity of various sex steroids for SHBG is dihydrotestosterone (DHT) > testosterone > androstenediol > estradiol > estrone.[6]

It decreases with high levels of insulin, growth hormone, insulin-like growth factor 1 (IGF-1), androgens, prolactin and transcortin.

 

[bridgeburn]

The world record holder for longest lived human to have ever lived is a woman who lived to be 122. She ate about 2.2 pounds of chocolate per week...
maybe the sugar helps postmenopausal with greater estradiol bio-availability via a slight decrease in Shbg? whereas sugar totally destroys men

 

[I'mme]

yes, bica reduces ARE(androgen response element) mechanism's of action over time

thats why after 3 months Bica reduced PSA by 86-94% and after 1 year it reduces PSA by +97%

https://www.ncbi.nlm.nih.gov/pubmed/21466228

I have always had one question but didn't ask it lest sounding stupid, can bicalutamide overtime render androgen receptors in Skin and hair useless?