Exploring The Hormonal Route. Hair=life.

[bridgeburn]

progesterone has partial agonist activity of the AR

what? no it doesn't. you must be thinking of synthetic progestins

 

[DHTcel]

what? no it doesn't. you must be thinking of synthetic progestins

"SAAs include CPA, megestrol acetate, chlormadinone acetate, and spironolactone.[73][74] These drugs are steroids, and similarly to NSAAs, act as competitive antagonists of the AR, reducing androgenic activity in the body.[75]:79 In contrast to NSAAs however, they are non-selective, also binding to other steroid hormone receptors, and exhibit a variety of other activities including progestogenic, antigonadotropic, glucocorticoid, and/or antimineralocorticoid.[73][74] In addition, they are not silent antagonists of the AR, but are rather weak partial agonists with the capacity for both antiandrogenic and androgenic actions"

your regimen looks good anyways though, you have gained lots of hair

 

[Screeech]

Are you all identifying as cisgender males, or are you somewhere else on the spectrum?

Not wanting to offend anyone in the slightest, just when I read through here from time to time it seems that you may not be which would explain why you are so prepared to pursue such aggressive regimens.

Personally I would not be prepared to pursue anything that produces feminising effects so just wondering if this stuff you are talking about is out of the question for someone in my position if I was to choose to do go down this path, or should I stop looking through this thread and focus on peppermint oil and LLLT?

 

[bridgeburn]

"SAAs include CPA, megestrol acetate, chlormadinone acetate, and spironolactone.[73][74] These drugs are steroids, and similarly to NSAAs, act as competitive antagonists of the AR, reducing androgenic activity in the body.[75]:79 In contrast to NSAAs however, they are non-selective, also binding to other steroid hormone receptors, and exhibit a variety of other activities including progestogenic, antigonadotropic, glucocorticoid, and/or antimineralocorticoid.[73][74] In addition, they are not silent antagonists of the AR, but are rather weak partial agonists with the capacity for both antiandrogenic and androgenic actions"

this is talking about progestins, not bio-identical progesterone

 

[bridgeburn]

Are you all identifying as cisgender males, or are you somewhere else on the spectrum?

Not wanting to offend anyone in the slightest, just when I read through here from time to time it seems that you may not be which would explain why you are so prepared to pursue such aggressive regimens.

Personally I would not be prepared to pursue anything that produces feminising effects so just wondering if this stuff you are talking about is out of the question for someone in my position if I was to choose to do go down this path, or should I stop looking through this thread and focus on peppermint oil and LLLT?

I live every moment without preconceived notions of myself

Personally I would not be prepared to pursue anything that produces feminising effects so just wondering if this stuff you are talking about is out of the question for someone in my position

Everthing is in question no matter your position, there are no rules. Some of us on here are masculine and take E or receptor blockers temporary or try to take it while fighting gyno with raloxifene or surgery, others don't mind feminizing at all and just nuke the system. Weigh the pros and cons and do what makes you happier.

 

[keepcoolmybabies]

Are you all identifying as cisgender males, or are you somewhere else on the spectrum?

Not wanting to offend anyone in the slightest, just when I read through here from time to time it seems that you may not be which would explain why you are so prepared to pursue such aggressive regimens.

Personally I would not be prepared to pursue anything that produces feminising effects so just wondering if this stuff you are talking about is out of the question for someone in my position if I was to choose to do go down this path, or should I stop looking through this thread and focus on peppermint oil and LLLT?

Unless you add estrogen, the feminizing effects will likely be limited to sebum reduction and slightly less body hair, as well as a chance of minor gyno. But the most noticeable effect (depending on the AA) would likely be reduced libido. And depending on your preference, that could be either a good a bad thing.

If you were to add estrogen though, you will get much more significant gyno and feminine fat distribution. But depending on your age, it won't affect bones if they've already fused.

Feminization could mean as little as looking like a younger guy but if growing boobs is out of the question, you definitely shouldn't consider estrogen.

Personally I could care less about my masculinity and have preferred all the effects of HRT.

But finasteride is probably a better first stepping stone if you are worried about any possible feminization. It should at least be a more potent option than peppermint oil and LLLT.

 

[bridgeburn]

It should at least be a more potent option than peppermint oil and LLLT.

LOL

 

[I'mme]

Are you all identifying as cisgender males, or are you somewhere else on the spectrum?

Not wanting to offend anyone in the slightest, just when I read through here from time to time it seems that you may not be which would explain why you are so prepared to pursue such aggressive regimens.

Personally I would not be prepared to pursue anything that produces feminising effects so just wondering if this stuff you are talking about is out of the question for someone in my position if I was to choose to do go down this path, or should I stop looking through this thread and focus on peppermint oil and LLLT?

Peppermint oil and LLLT won't do a sh*t if you have aggressive hair loss. If you're Norwood 1.5/2 who is very slowly receding then might want to stay on those, else start off with Big3.

 

[I'mme]

But the most noticeable effect (depending on the AA) would likely be reduced libido. And depending on your preference, that could be either a good a bad thing.

Cis male here. I find low libido a good thing, for I become horny at my will and erections/orgasms are much more better and longer.

 

[Screeech]

Peppermint oil and LLLT won't do a sh*t if you have aggressive hair loss. If you're Norwood 1.5/2 who is very slowly receding then might want to stay on those, else start off with Big3.

Yeah, I know. The peppermint oil/ LLLT comment was more of a meme than anything, lol.

I'm using clascoterone at the moment and tried finasteride before that but it did nothing.

I would be keen to try something more hardcore that gave good results if it meant there were no longstanding side effects in the event the more 'gentler' things I'm planning don't work.

As long as the erection quality came back post usage.

I also read something about inherently feminising treatments causing something like feminised skin(?).

I've found that clascoterone has stopped my hair loss seemingly entirely, so if I could take something harder for a period which regrew any loss and then go back to clascoterone for maintaining that would be very appealing.

I wonder if using stronger anti-androgens does something to the receptors which would thereafter make weaker ones impotent. That would obviously obviate that plan from being an option.

Anyway, I don't want to take up your time by doing Q&A.

I will do my own digging, just wanted to know what type of characters were engaging in this thread.

Carry on.

 

[jenny-death]

Hello, thought I'd post some pictures.

Here are my temples under some precariously hard to get lighting, you can see all the fuzzies where my hairline in general used to be. Still shedding an insane amount, haven't really noticed them getting any bigger either.

 

[jenny-death]

Are you all identifying as cisgender males, or are you somewhere else on the spectrum?

Not wanting to offend anyone in the slightest, just when I read through here from time to time it seems that you may not be which would explain why you are so prepared to pursue such aggressive regimens.

Personally I would not be prepared to pursue anything that produces feminising effects so just wondering if this stuff you are talking about is out of the question for someone in my position if I was to choose to do go down this path, or should I stop looking through this thread and focus on peppermint oil and LLLT?

I'm non-binary, I value my feminine traits over my masculine ones, especially for aesthetics. So does my boyfriend. That's why I'm pretty happy to do this. Personally, I'd never recommend it to anyone other than a trans person, it will definitely feminize you.

 

[I'mme]

Yeah, I know. The peppermint oil/ LLLT comment was more of a meme than anything, lol.

I'm using clascoterone at the moment and tried finasteride before that but it did nothing.

I would be keen to try something more hardcore that gave good results if it meant there were no longstanding side effects in the event the more 'gentler' things I'm planning don't work.

As long as the erection quality came back post usage.

I also read something about inherently feminising treatments causing something like feminised skin(?).

I've found that clascoterone has stopped my hair loss seemingly entirely, so if I could take something harder for a period which regrew any loss and then go back to clascoterone for maintaining that would be very appealing.

I wonder if using stronger anti-androgens does something to the receptors which would thereafter make weaker ones impotent. That would obviously obviate that plan from being an option.

Anyway, I don't want to take up your time by doing Q&A.

I will do my own digging, just wanted to know what type of characters were engaging in this thread.

Carry on.

Spironolactone seems to have relative weak AA activity among used AAs here. Also has great regrowth results under its arsenal.
Re your approach, a guy named jgray did this and was successful. After being here for some months now and reading years of experiences, I've come to realise that you can tinker with Anti-androgens but you will regret if you did 5mg finasteride/2.5mg Duta and go back to sth weaker. So keep this in mind.

Yup, Spironolactone would provide slight feminization by itself. I have the best skin I've ever had. Exactly 0 acne.

 

[I'mme]

I'm non-binary, I value my feminine traits over my masculine ones, especially for aesthetics. So does my boyfriend. That's why I'm pretty happy to do this. Personally, I'd never recommend it to anyone other than a trans person, it will definitely feminize you.

No Anti-androgen, not even Bicalutamide or Cypro can feminize anyone much without Estrogen.

 

[jenny-death]

No Anti-androgen, not even Bicalutamide or Cypro can feminize anyone much without Estrogen.

It's not safe to so do so without estrogen though. But people can try if they like.

 

[bridgeburn]

No Anti-androgen, not even Bicalutamide or Cypro can feminize anyone much without Estrogen.

but Bica increases estrogen

 

[I'mme]

but Bica increases estrogen

It increases estrogen because it increases testosterone. I've yet to see a study that concluded that it has direct estrogenic effects.

 

[I'mme]

It increases estrogen because it increases testosterone. I've yet to see a study that concluded that it has direct estrogenic effects.

Moreover Cypro reduces both that would make the taker extremely weak.

 

[Ikarus]

It increases estrogen because it increases testosterone. I've yet to see a study that concluded that it has direct estrogenic effects.

It increases T and E due to an increase in LH. It will lead to de-masculinisation, not direct feminising effects such as fat redistribution.

 

[I'mme]

It increases T and E due to an increase in LH. It will lead to de-masculinisation, not direct feminising effects such as fat redistribution.

What would be de-masculinisation when bone density, voice, facial looks, fat redistribution won't happen? Boobs, nopes... any AA would do that.