The AR gene contains CAG repeats which affect receptor function, where fewer repeats leads to increased receptor sensitivity to circulating androgens and more repeats leads to decreased receptor sensitivity. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756810/
Exploring The Hormonal Route. Hair=life.
- Thread starter bridgeburn
- Start date
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Is Bica the least side effect prone of the two?
That's a great site, cheers. Is it dodgy at all?
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How is your hair doing?
Same as it was before treatment (about 3m before)
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Hey Ikarus, Thanks ! I'm keeping my fingers crossed
I've been losing my hair since I was 20. I'm 35 today. Since these 15 years of fighting against this baldness, I have done two hair surgeries and I have tried the topical minoxidil and duta....
On my Hairline, I am norwood 3 (Big temples)... otherwise, I am a diffuse norwood 5 (I have thin hairs)... It's thanks to the hair grafts that I still have hair on the top... So I would say Norwood 5 diffuse.....
I hope that you have more hairs and have regrowth to become Norwood 0 again !
Not really... Few hairs in my hands but it's nothing compared to before the HRT
Congrats, looking good.
I've been slick/shiny bald on my temples since ~1996. Amazingly over the past few months im starting to see terminal hairs in this area again
(I'm using a similar regimen to you)
Hi ! Thank you
Wowww... since 1996 ! It's been a long time and I'm very happy for you that you have regrowth too !! yes... it's a very slooooow progress
I look forward to seeing your results too
It's good to see that many of us are on this similar regimen and to see that it works for you too.
Yes my first order was shipped by them too... but they were very slow to send me the order (1 month)....
Thanks dude !
At the beginning of the regimen, I had no libido... but today I have my libido back... Mentally it hasn't changed, and neither has it physically. However, for a few details, I no longer make sperm... so cyproterone acetate it's a pretty powerful drug ... I'm a cis male and I think in a few months (December) I will take bica instead of cypro...
@I'mme
Thanks I'll consider upping it, however Minoxidil is already causing me to grow new hair under my eyes and above my eyebrows. Which isn't a good look
Yeah me too ! I have new hairs just under my eyes...
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@Father_of_Shiseido : don't be a child with your dislikes on every posts of mine.
Put me on your ignore list. Grow up buddy.
And spend your time on an another website because you are not balding kid.
Put me on your ignore list. Grow up buddy.
And spend your time on an another website because you are not balding kid.
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I don't know of the entirety of bicas side profile but it is my understanding that it's rate of gyno is significantly higher than cpa
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its less likely to give fertility and libido sides.
but systematically it is more estrogenic and can give more sides.
@BananaBlunt hi obsolete thinker - how do you come up with so amazing names?
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Seems legit. Lets see if it arrives. Wondering if medicine from online pharmacy's slips easy through customs here. Patience i guess.
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They don't necessarily make skin look bad, but can in certain prone individuals. Androgens increase sebum production, which can lead to oily skin and blocked pores/acne. Estrogen meanwhile limits sebum production and also increases collagen, making skin softer.
Additionally, it all depends on what type of skin you have for whether androgens or estrogens might benefit or make the problem worse. Dry skin or eczema could be exacerbated by estrogen whereas oily skin and seborrheic dermatitis could be exacerbated by androgens.
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female-to-male. skin looks more rough and oily:
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the follicles are connected to the bloodstream, therefore, serumn DHT can add to the problem even if it isn't the primary cause
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wait did you get man boobs bridge? i'm extremely depressed about being bald and seriously considered HRT but i already have beta gay face. and man boobs would make it all pointless, as would a feminine face (i think? honestly seems like girls would prefer a femme dude over a bald guy) . i also read some f*****g terrifying things linking these hormones to heart disease , blood pressure issues and certain kinds of cancer.
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life's so f*****g meaningless as a 5'6 bald guy but my inhibitions are way too high to really do anything
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I always hated my skin since I was a teenager until I took hormones. I like looking healthy
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"Current use of bicalutamide 50 mg/day was associated with a significant increase in the risk of HF (OR 3.28; 95% CI 1.31, 8.18); however, this increased risk of HF was only found in patients taking bicalutamide 50 mg/day in combination with luteinizing hormone-releasing hormone (LHRH) receptor agonists. There were no cases of hospitalized HF in patients taking bicalutamide 50 mg/day as monotherapy and there was no significant association between current use of bicalutamide 150 mg/day and the risk of hospitalized HF"
https://www.ncbi.nlm.nih.gov/m/pubmed/21981434/
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yeah I got boobs
honestly, even if I had a million hot girls chasing me, I would not have peace within myself If I was bald.
androgens are also linked to heart disease and cancer.. I believe that estrogen is pretty healthy but too much of anything is bad of course.. It is also my belief that it increases lifespan:
"We measured the rate of H2O2 production in the presence of succinate or malate plus pyruvate. In both cases, mitochondria from females produced approximately half the amount of H2O2 than those from males. "
"We have found (Table 1) that the levels of 8-oxo-deoxyguanosine (8-oxo-dG) (an excellent indicator of oxidative damage to DNA) are fourfold higher in males than in females [10]. This is the highest change we have observed in mitochondrial DNA oxidation in any physiological situation and shows that the chronic, continuous, increase in free radical production in males results in a marked oxidative and mutagenic lesion in mitochondrial DNA [18]."
" A few years ago Orr and Sohal [21] observed that Drosophila that overexpress either SOD or catalase (they lack GPx) did not increase their average life span. However, when they overexpressed both, the life span was increased. We have found that females overexpress both superoxide dismutase and GPx (both of them mitochondrial enzymes, Table 1). Moreover, this increase can be attributed to oestrogens (see below)."
"
Expression of 16S ribosomal RNA (16S rRNA) and glutathione levels, both biological markers of ageing, show that females are younger than males of the same chronological age"
" Thus, we tested [10] the hypothesis that if females are biologically younger than males of the same chronological age, they ought to express more 16S rRNA than males. This is indeed the case and the expression of 16S rRNA is more than threefold higher in females than in males of the same age (Table 1)."
" mitochondrial H2O2 production is significantly increased (by more than 50%) after ovariectomy and this is completely prevented when ovariectomised rats are treated with oestradiol at doses similar to those used in oestrogen replacement therapy (for details see [9])."
"The effect of oestradiol as an upregulator of antioxidant, longevity-related genes indicates that its administration might be beneficial to increase longevity, particularly of males, to reach a life span similar to females."
https://www.sciencedirect.com/science/article/pii/S0014579305004540
However, the downside is that the liver releases clotting factors whenever it processes estrogen. That's why oral administration is riskier and also synthetic types of E such as that found in birth control is much riskier than bio-identical.