Exploring The Hormonal Route. Hair=life.

I'mme

Experienced Member
My Regimen
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686
I think it's a combo. But agree that E is likely necessary for regrowth. This person transitioned without an added AA or 5ari and experienced a ton of regrowth.... https://www.reddit.com/r/transtimelines/comments/dkas39/im_doing_better_can_you_tell/

Granted she's on E injections which can inhibit T as a monotherapy much more effectively than pills. But still proof that E alone can grow a lot of hair.
I might just start applying oestrogel on my crown. But lemme wait..
 

keepcoolmybabies

Experienced Member
My Regimen
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1,108
I mentioned this a while back but most folks said you need AA or 5ar inhibitors, which I don't believe it's the case.

Please refer to this stunning and revolutionary article done in Germany: https://academic.oup.com/edrv/article/27/6/677/2355194

The title says it all:

The Hair Follicle as an Estrogen Target and Source.

I HIGHLY SUGGEST YOU READ EVERY SINGLE LINE LIKE YOUR LIFE DEPENDED ON IT.
The example I provided of E monotherapy was someone on injections which can bring T to castration levels without an AA. But as most people here seem to use either pills or gel it might still be necessary to be on an AA or 5ari for cessation of hair loss / regrowth, since serum T will otherwise still be relatively high.
 

bridgeburn

Senior Member
My Regimen
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3,614
I think maybe I've been gaining more fat in the cheeks these days,
IMG_20191031_173622.jpg
 

bridgeburn

Senior Member
My Regimen
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3,614
I put on close to 12lbs of water weight on oral minoxidil, i know you have cut it down to twice a week but have you noticed any weight difference since stopping spironolactone?
haven't weighed myself in awhile, I don't own a scale
 

supermusic

Established Member
Reaction score
34
Under your experience, what could be the minimum dose of bica to use as monotherapy and get improvements in hair and avoid gyno?
Thanks
 

Gaz121

Member
My Regimen
Reaction score
12
Hi guys, I'm looking for some advice on the next step I should take.

I've been on HRT for most of this year using the regimen below. I'm a diffuse thinner from the crown to the hairline. I've achieved some vellus hair regrowth, however, I'm still noticeably losing hair as my hair loss is progressing. Does this make any sense to you? I thought my hair loss would stop and then I'd have some regrowth?

Regimen
- 50mg Cypro daily (9 months so far)
- 2mg Estro Pill daily in morning (9 months so far)
- 3.75mg Estrogel daily in evening (8 months so far)
- 0.5mg Avodart Pill daily (6 months so far)
- Topical Minoxidil daily (15 years so far)
- 1mg Finasteride pill daily (15 years so far)

I also got my testosterone and estrogen levels measured recently. The results were as follows:
Testosterone is 0.45 nmol/L
Oestradiol is 10,163 pmol/L
I carried out the blood test for Oestradiol levels 7 hours after taking the 2mg Estrofem pill in the morning. So as you can see, I'm in the female range.

Taking into account the above results, can you advise what further steps I could take? Should I increase / change the current dosages or add further meds? Bridgeburn mentioned in a private message that I should switch to Bicalutimide but I'm not sure if the Bicalutimide should be replacing anything that I'm currently taking or added to my current regimen? Any help is much appreciated!
 

supermusic

Established Member
Reaction score
34
Hi guys, I'm looking for some advice on the next step I should take.

I've been on HRT for most of this year using the regimen below. I'm a diffuse thinner from the crown to the hairline. I've achieved some vellus hair regrowth, however, I'm still noticeably losing hair as my hair loss is progressing. Does this make any sense to you? I thought my hair loss would stop and then I'd have some regrowth?

Regimen
- 50mg Cypro daily (9 months so far)
- 2mg Estro Pill daily in morning (9 months so far)
- 3.75mg Estrogel daily in evening (8 months so far)
- 0.5mg Avodart Pill daily (6 months so far)
- Topical Minoxidil daily (15 years so far)
- 1mg Finasteride pill daily (15 years so far)

I also got my testosterone and estrogen levels measured recently. The results were as follows:
Testosterone is 0.45 nmol/L
Oestradiol is 10,163 pmol/L
I carried out the blood test for Oestradiol levels 7 hours after taking the 2mg Estrofem pill in the morning. So as you can see, I'm in the female range.

Taking into account the above results, can you advise what further steps I could take? Should I increase / change the current dosages or add further meds? Bridgeburn mentioned in a private message that I should switch to Bicalutimide but I'm not sure if the Bicalutimide should be replacing anything that I'm currently taking or added to my current regimen? Any help is much appreciated!
Any sides with your regime?
 

Ikarus

Banned
My Regimen
Reaction score
2,943
Hi guys, I'm looking for some advice on the next step I should take.

I've been on HRT for most of this year using the regimen below. I'm a diffuse thinner from the crown to the hairline. I've achieved some vellus hair regrowth, however, I'm still noticeably losing hair as my hair loss is progressing. Does this make any sense to you? I thought my hair loss would stop and then I'd have some regrowth?

Regimen
- 50mg Cypro daily (9 months so far)
- 2mg Estro Pill daily in morning (9 months so far)
- 3.75mg Estrogel daily in evening (8 months so far)
- 0.5mg Avodart Pill daily (6 months so far)
- Topical Minoxidil daily (15 years so far)
- 1mg Finasteride pill daily (15 years so far)

I also got my testosterone and estrogen levels measured recently. The results were as follows:
Testosterone is 0.45 nmol/L
Oestradiol is 10,163 pmol/L
I carried out the blood test for Oestradiol levels 7 hours after taking the 2mg Estrofem pill in the morning. So as you can see, I'm in the female range.

Taking into account the above results, can you advise what further steps I could take? Should I increase / change the current dosages or add further meds? Bridgeburn mentioned in a private message that I should switch to Bicalutimide but I'm not sure if the Bicalutimide should be replacing anything that I'm currently taking or added to my current regimen? Any help is much appreciated!

Why is your estradiol levels over 10000 pmol/L?
 

keepcoolmybabies

Experienced Member
My Regimen
Reaction score
1,108
Hi guys, I'm looking for some advice on the next step I should take.

I've been on HRT for most of this year using the regimen below. I'm a diffuse thinner from the crown to the hairline. I've achieved some vellus hair regrowth, however, I'm still noticeably losing hair as my hair loss is progressing. Does this make any sense to you? I thought my hair loss would stop and then I'd have some regrowth?

Regimen
- 50mg Cypro daily (9 months so far)
- 2mg Estro Pill daily in morning (9 months so far)
- 3.75mg Estrogel daily in evening (8 months so far)
- 0.5mg Avodart Pill daily (6 months so far)
- Topical Minoxidil daily (15 years so far)
- 1mg Finasteride pill daily (15 years so far)

I also got my testosterone and estrogen levels measured recently. The results were as follows:
Testosterone is 0.45 nmol/L
Oestradiol is 10,163 pmol/L
I carried out the blood test for Oestradiol levels 7 hours after taking the 2mg Estrofem pill in the morning. So as you can see, I'm in the female range.

Taking into account the above results, can you advise what further steps I could take? Should I increase / change the current dosages or add further meds? Bridgeburn mentioned in a private message that I should switch to Bicalutimide but I'm not sure if the Bicalutimide should be replacing anything that I'm currently taking or added to my current regimen? Any help is much appreciated!
Your E is over 10x higher than anything resembling ideal levels. Either that's a lab mistake or typo, or you are ultra sensitive to E supplementation (or maybe your gel dosage is off). If it's really that high you should consider adjusting dosages.
 

keepcoolmybabies

Experienced Member
My Regimen
Reaction score
1,108
Under your experience, what could be the minimum dose of bica to use as monotherapy and get improvements in hair and avoid gyno?
Thanks
I actually think bica monotherapy might be a risky idea and and may even cause more harm than good. Bica can more than double T levels unless paired with E or other GNRH anaologue. And while (depending on dosage) the extra free T is likely to be blocked at the androgen receptor, bica does not prevent 5ar from converting that surplus of T into DHT which is a far more potent androgen and has up to a 100x more affinity for the receptors than bica.

Where bica probably shifts into being more advantageous is by limiting the rise of T with a med that affects HPG axis. Or at the very least pairing it with a 5ari to prevent much of the extra T from being converted to DHT.
 

Gaz121

Member
My Regimen
Reaction score
12
Your E is over 10x higher than anything resembling ideal levels. Either that's a lab mistake or typo, or you are ultra sensitive to E supplementation (or maybe your gel dosage is off). If it's really that high you should consider adjusting dosages.
I’ve just double checked the lab results and their definitely correct. I actually got my bloods tested at two different occasions and their both around 10,000 pmol/L for Oestradiol.

What’s the level of E I should be aiming for that would be considered sufficient as part of HRT?

Should I add Bicalutimide?
 
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