Exploring The Hormonal Route. Hair=life.

[keepcoolmybabies]

I beg to disagree. His facial fat have deposited in female like pattern. He wouldn’t be able to pass as a man even if grows a beard.

I think a decent amount of facial hair would serve as a more noticeable gender clue than facial fat. And unless every stranger he currently encounters refers to him initially as a female I think he's likely still "passing" for a guy. Granted, he could probably choose to be perceived either way if he wanted since he has great androgynous features.

 

[whatintheworld]

I think a decent amount of facial hair would serve as a more noticeable gender clue than facial fat. And unless every stranger he currently encounters refers to him initially as a female I think he's likely still "passing" for a guy. Granted, he could probably choose to be perceived either way if he wanted since he has great androgynous features.

Facial fat is one thing, but it almost seems like his jaw structure has changed as well. The entire geometry of his face has become more feminine, it is incredible how potent hormonal changes can be.

I would have legitimately thought him as a girl from birth from that last photo.

 

[pegasus2]

I haven't seen the 73 year old on sprio before. That is very surprising. I wonder what would've happened if he had taken minoxidil too. You'll notice though on all of these older men who get regrowth it's always wispy. They never regrow thick hair with the exception of wounding which creates new follicles. The question is, why are these old men able to revive some of the hairs throughout the vertex, but not the others? They've all been long gone, so what makes the ones that come back so special? And if a follicle can come back after that long, why can't we get all of ours back if it's only been 5-10 years?

It is so hard to figure out the many ways in which hair growth and loss work. Unless you make your living in hair research there's no way you'll ever have time to crack the code. We will have the cure long before we fully understand the mechanisms behind it all.

 

[Yar]

But my philosophical question is why is there a point of no return or is the contrary true? It really is important to get to the bare bottom of this enigma.

If anyone can please elucidate, that would make me sleep in peace.

Is there light at the end of the tunnel for men balding for more than 10 years?

Here are some cases proving how this can be the case:

1. Took this man 6 years to regrow a good portion of hair off spironolactone: "This 73-year-old white male has been bald since the age of 28. He developed nonA-nonB-induced liver cirrhosis and had been treated with spironolactone for the last 6 years. For the last 3 months, his hair had started to regrow over the scalp. This might be related to the antiandrogenic effect of spironolactone." Source: https://www.ncbi.nlm.nih.gov/pubmed/1977262

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Extreme case solely from ONE AND ONE DRUG only with a balding duration of 45 years. This alone suffices to give me enough hope as I am a diffuse Norwood 3/3v balding for 8 years now.

2. BBQ 78 year old man burns scalp and regrows hair:

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3. Reversal of male pattern baldness for 75 year old man balding for 30 years. Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1498062/?page=1

4. Just when it couldn't get better. A 90 Year Old Man Regrows Hair Off Topical Zinc Thymulin: Source: https://www.longdom.org/open-access/an-analysis-of-the-safety-and-efficacy-of-topical-zincthymulin-to-treat-androgenetic-alopecia-2167-0951-1000147.pdf

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So I beg anyone for the life of me, please help me better understand what it means when people say no point of return given the aforementioned case studies?

I strongly feel that the reason why most treatments - and even to SOME extent HRT - fails in REGROWING full heads of hair is because they share one thing in common: tackling one or a few layers of the Androgenetic Alopecia avalanche.

What we really need is an atomic bomb tackling every single problematic layer that is caused by Androgenetic Alopecia. A multi-faceted treatment plan that consists of:

1. E2 and progesterone to reverse the fibrosis, calcification, and hypoxia layers and encourage stem cell proliferation and cross talk signaling with the various modulators (FGF-7, PGE2, VEGF, WNT-10b, etc.);
2. Anti-DHT concoctions to tackle the DHT causation layer;
3. Supplements to tackle the malnourished follicular and inflammatory layer;
4. Iodine to tackle the thyroid disorder layer as adequate T3 production is A DIRECT TARGET FOR HAIR FOLLICLE GROWTH;
5. Green tea or another potent anti-stress agent to tackle the oxidative stress layer;

I think you get the point. You can't just place your focus on one type of treatment. It has to be synergistic otherwise your chance of success may be low or you full regrowth may not be achievable.

Thoughts????

spironolactone makes you body produce progesterone which protects the prostate from androgens

 

[Derelict]

nvm

 

[Yar]

so which is more effective: spironolactone or E2?

spironolactone with estradiol only, 50-100 mg spironolactone + 1-2 mg estradiol. for the night

 

[I'mme]

I beg to disagree. His facial fat have deposited in female like pattern. He wouldn’t be able to pass as a man even if grows a beard.

Facial fat is one thing, but it almost seems like his jaw structure has changed as well. The entire geometry of his face has become more feminine, it is incredible how potent hormonal changes can be.

I would have legitimately thought him as a girl from birth from that last photo.

In that pic angle is different and he is smiling. He didn't have protruding jaw before if you see his pics. The only difference I see is lack of facial hair and more facial fat.
If hormones were that powerful, trans people would have easier time transitioning, but this sure isn't the case. Most MTF cases I have seen always upload their worst pic before transition (or one of the worst) and their best pic after transitioning (with loads of makeup and feminising products). There's nothing wrong with it - I'm saying this just to prove that it's not *that* easy for everyone to look like opposite gender just by using hormones. Sure, some guys like Ikarus, me etc would have easier time because we already look androgynous to begin with ( I had shaved yesterday and was told by 3 friends that I'm looking very feminine).

 

[I'mme]

Testosterone OTOH may be very powerful. I just opened transtimeline and got to see this.

Though there are many reasons why going ftm isn't worth it unless the concern has severe disphoria.

 

[Yar]

what do you think what levels of estradiol can be achieved by 2 mg orally estrofem and 2 doses of estrogel 0.75 mg per thigh and buttocks

 

[Obsessive]

what do you think what levels of estradiol can be achieved by 2 mg orally estrofem and 2 doses of estrogel 0.75 mg per thigh and buttocks

Yar-why is progesterone not used by many on this forum? I have topical progesterone and have used it sporadically, but am hesitant to commit without any positive experience stories.

 

[Yar]

Yar-why is progesterone not used by many on this forum? I have topical progesterone and have used it sporadically, but am hesitant to commit without any positive experience stories.

maybe because it can be converted to androgen. I had a female breast, on estradiol somewhere around 0.5. After taking several days of progesterone 100 mg each, my breasts decreased slightly. It acts as an antagonist of estradiol.

 

[Obsessive]

No

You and I are only ones using e2 on scalp. is this a good idea? sometimes it seems it makes my loss worse.

 

[Yar]

[QUOTE = "Обсессив, пост: 1848585, участник: 138005»] Ярко-почему прогестерон не используется опыта. [/ QUOTE]

You and I are only ones using e2 on scalp. is this a good idea? sometimes it seems it makes my loss worse.

for. In order for estradiol to start working in the scalp, you first need to clean the receptor with progestin. Cyproterone acetate. But be sure to add estradiol to Cyproterone and take it staggered

 

[LEXUS]

Yar-why is progesterone not used by many on this forum? I have topical progesterone and have used it sporadically, but am hesitant to commit without any positive experience stories.

because progesterone in people with hair loss turns into androgen. some articles even call progesterone androgen. since in the male body it turns into androgens. progesterone can improve the condition of the hair only to those who do not have hair problems. Progesterone is prohibited for people with baldness. and only estradiol can help.

 

[LEXUS]

[QUOTE = "Обсессив, пост: 1848585, участник: 138005»] Ярко-почему прогестерон не используется опыта. [/ QUOTE]

for. In order for estradiol to start working in the scalp, you first need to clean the receptor with progestin. Cyproterone acetate. But be sure to add estradiol to Cyproterone and take it staggered

no one has grown water on progesterone. logically, he should help, but no.

 

[LEXUS]

You and I are only ones using e2 on scalp. is this a good idea? sometimes it seems it makes my loss worse.

What is e2? I use estrogel. What is the difference e 1 2 3? I do not understand. the fact is that estradiol contains alcohol, and therefore harms the scalp. and as the jar said, you need to use at least 12.5 mg of cpa and only then smear his estrogel

 

[Yar]

no one has grown water on progesterone. logically, he should help, but no.

I'm going to try it, but first I need to reach estradiol level of women 200-250pg / ml

 

[LEXUS]

You and I are only ones using e2 on scalp. is this a good idea? sometimes it seems it makes my loss worse.

first I smear estrogel and then smear minoxidil, so thanks to minoxidil, estrogel dries for about 5 hours almost all night, my head continuously receives estradiol. it is more effective than pills

 

[LEXUS]

You and I are only ones using e2 on scalp. is this a good idea? sometimes it seems it makes my loss worse.

as I said estrogel harms the skin. and can get worse. For this I use vitamins for regeneration. Vitamin C, B vitamins, calcium calcium, magnesium and vitamin D, iron, manganese, and copper. melatonin is a hormone of youth. and protein, for the healing of skin lesions from estrogel. nutrition is also very important.

 

[Mr. Grey]

I use now 4 mg of estrogen + duta and this not working without anti androgen. All hair which i have got with cpa is getting out ( 6 weeks ago i stopped cpa).