Exploring The Hormonal Route. Hair=life.

[Thatguy0]

I think that the androgen receptors in the muscles are partially blocked.
I'll continue training and see what happens

* I take 50 mg Bicalutamide (per day)
0.5 mg Avodart (every second day)
2 mg Estradiol ( per day)

i'll be ordering 50mg bic and 2mg estradiol, what was your experience with these two? did you notice improvements after taking it?

 

[Jacob Williams]

Can I build muscle if I take bicalutamide?
Or is it impossible? After all, the androgen receptors are blocked.

As someone who started bodybuilding while taking bicalutamide I feel more qualified to answer this than others who have no experience. I’ve personally seen huge gains. It’s likely that bicalutamide is actually helping me build muscle because it increases your testosterone.

 

[Jacob Williams]

As someone who started bodybuilding while taking bicalutamide I feel more qualified to answer this than others who have no experience. I’ve personally seen huge gains. It’s likely that bicalutamide is actually helping me build muscle because it increases your testosterone.

For reference I’ve been on bicalutamide 100mg for around 6 months. I started lifting seriously 2 months in. I’ve gained around 15 pounds, all my lifts have increased substantially and I’m very obviously more muscular than before.

 

[Jacob Williams]

Do y’all think that dutasteride is necessary in my situation or can bicalutamide alone control my hair loss? I’ve never tried going off it but it’s expensive and a hassle to get prescribed. I was trying to get a 90 day prescription instead of a 30 day prescription from a new doctor and they’re making me do a thyroid stimulating hormone test....do any of y’all know if the drugs I’m taking would cause me to have abnormal results?

 

[keepcoolmybabies]

Do y’all think that dutasteride is necessary in my situation or can bicalutamide alone control my hair loss? I’ve never tried going off it but it’s expensive and a hassle to get prescribed. I was trying to get a 90 day prescription instead of a 30 day prescription from a new doctor and they’re making me do a thyroid stimulating hormone test....do any of y’all know if the drugs I’m taking would cause me to have abnormal results?

I think dutasteride might still be necessary if you aren't on a gnrh antagonist and bica monotherapy can be its own potential hair loss powderkeg since it doesn't stop the conversion of T to DHT. Instead it simply competes for the same receptors whilst having far less affinity for them than DHT. And if you simultaneously block T from binding to AR while raising it, the extra T can then be converted to the more potent DHT which will then out compete bica (unless you are taking a sh*t ton).

 

[baba_yaga]

Do y’all think that dutasteride is necessary in my situation or can bicalutamide alone control my hair loss? I’ve never tried going off it but it’s expensive and a hassle to get prescribed. I was trying to get a 90 day prescription instead of a 30 day prescription from a new doctor and they’re making me do a thyroid stimulating hormone test....do any of y’all know if the drugs I’m taking would cause me to have abnormal results?

Please let us know how it goes for you. There isn't many members who are currently on bica.

 

[Obsessive]

Do y’all think that dutasteride is necessary in my situation or can bicalutamide alone control my hair loss? I’ve never tried going off it but it’s expensive and a hassle to get prescribed. I was trying to get a 90 day prescription instead of a 30 day prescription from a new doctor and they’re making me do a thyroid stimulating hormone test....do any of y’all know if the drugs I’m taking would cause me to have abnormal results?

We are in a rare category: males who lift weights while using bica. So you've been using 50 mg/day for 6 months? Aside from gym gains, how are hair gains?

I'm essentially microdosing bica (12.5 mg/EoD) while also using spironolactone and finasteride. Plan to bump up bica dose and drop spironolactone soon.

 

[ali.talebi1994]

I think dutasteride might still be necessary if you aren't on a gnrh antagonist and bica monotherapy can be its own potential hair loss powderkeg since it doesn't stop the conversion of T to DHT. Instead it simply competes for the same receptors whilst having far less affinity for them than DHT. And if you simultaneously block T from binding to AR while raising it, the extra T can then be converted to the more potent DHT which will then out compete bica (unless you are taking a sh*t ton).

The affinity of bicalutamide for the AR is relatively low as it is approximately 30 to 100 times lower than that of DHT, which is 2.5- to 10-fold as potent as an AR agonist as testosterone in bioassays and is the main endogenous ligand of the receptor in the prostate gland. However, typical clinical dosages of bicalutamide result in circulating levels of the drug that are thousands of times higher than those of testosterone and DHT, allowing it to powerfully prevent them from binding to and activating the receptor.
source: https://en.wikipedia.org/wiki/Bicalutamide#Pharmacodynamics

 

[ali.talebi1994]

For reference I’ve been on bicalutamide 100mg for around 6 months. I started lifting seriously 2 months in. I’ve gained around 15 pounds, all my lifts have increased substantially and I’m very obviously more muscular than before.

how much has bica helped you to treat hair loss

 

[keepcoolmybabies]

The affinity of bicalutamide for the AR is relatively low as it is approximately 30 to 100 times lower than that of DHT, which is 2.5- to 10-fold as potent as an AR agonist as testosterone in bioassays and is the main endogenous ligand of the receptor in the prostate gland. However, typical clinical dosages of bicalutamide result in circulating levels of the drug that are thousands of times higher than those of testosterone and DHT, allowing it to powerfully prevent them from binding to and activating the receptor.
source: https://en.wikipedia.org/wiki/Bicalutamide#Pharmacodynamics

Bica dosage levels were established primarily based on prostate cancer treatment, of which its not FDA approved as a monotherapy and requires use of an lhrh analogue to prevent the rise in T.

Monotherapy is used in a variety of other countries than the US, however, but at a typical dosage of 150mg, which is far higher than most people would likely consider taking for hair loss. And even at that dose, it's less effective than being combined with dutasteride, possibly for the reason I mentioned.

"PSA progression was found in 52 patients [65.8 %; 95 % confidence interval (CI) 55.4–76.3] in the monotherapy group compared to 38 patients (53.5 %; 95 % CI 41.9–65.1) in the combined therapy group (p = 0.134)."

 

[baba_yaga]

Could the adrenal glands become overworked in the long term and stop working correctly when producing double androgen levels due to taking bica? I havent found any study mentioning this. Any ideas?

 

[Kira Marie]

What about those of us whom have had an Orchiectomy? {I'm taking IM-EV, 25mg bica, and .05mg dutasteride.}

 

[Ikarus]

Could the adrenal glands become overworked in the long term and stop working correctly when producing double androgen levels due to taking bica? I havent found any study mentioning this. Any ideas?

I don’t think the adrenal glands produce more testosterone due to bicalutamide

 

[baba_yaga]

I cant seem to find any article/page mentioning Addison's disease being caused indirectly by bica. As for orchiectomy, if I remember correctly, can cause this disease unfortunately.

We must dig deeper.

 

[baba_yaga]

I don’t think the adrenal glands produce more testosterone due to bicalutamide

Like testes are the main source of T, and adrenal glands produce small quantities. So there shouldnt be any complications?

 

[Kira Marie]

I'm not worried, just curious. I may drop down to 12.5mg eventually anyway. Seems a majority (in my situation) are satisfied with that dose. Less meds=less risk.

 

[Karan48281]

How long does it take for CPA at 12.5mg a day for it to start working? It is a gradual process of lowering testosterone?

 

[coco_304]

1.25mg Oestrogel applied on inner thigh

What is for??

 

[Jjflash]

Is it more effective to be on 1.5 mg Duta or 1 mg Duta + 50 mg Bica?
What do you think?

 

[LEXUS]

1.5 duta