Yes, Bica is better than Cypro. Alot of people don't know that, when Cypro lowers Androgen levels low enough (sometimes in combination with E), it can activate AR receptors (CPA works as a weak androgen in this case).
Source : In accordance with its albeit weak capacity for activation of the AR, CPA has been found to stimulate androgen-sensitive
carcinomagrowth in the absence of other androgens, an effect which could be blocked by co-treatment with flutamide.
[31][53][54] In one study in rodents, DHT-stimulated prostate weight remained 40% above controls with administration of CPA even at the highest dosage, while flutamide was able to completely block the stimulatory effects of DHT.
[57]
Bica on the other hand, blocks ARs, resultng in no androgen contact with the AR (provided you know the Bica dose you should be taking). Further more, Bica degrades ARs with time. But one important thing, if you are keen on using Bica, you should use it long term. An inappropriate dose or method, can result in AR upregulations. And since Bica is quite expensive, Cypro/spironolactone seem more attractive, and in a way they are (they do their job well).
Very good explanation
thank you
commented on dutasteride with some AA and forgot to mention
duct + spironolactone
the cost of spironolactone is much lower than that of the bica
could you try the duta + spironolactone before entering the bica ?
or the efficiency / collateral of the spironolactone is very low.
Cypro is very effective in low doses (12.5 mg) as opposed to the general idea of 50 mg+ . The starting dose (for trans at least) is 12.5 mg, increased only if T levels aren't reduced by ~70% after weeks of administration (and then reduced back once T suppression is acheived). For spironolactone, the starting dose is 50 mg, increased slowly if no signs of skin/hair improvements are seen after sometime (rarely a 400 mg dose has been used, and this dose is quite unhealthy).
