Exploring The Hormonal Route. Hair=life.

[DiffuseSucks]

I stopped using spironolactone around a year ago, I think




I would but knowing the people on this website, and how they like to attempt to humiliate people on such a regimen, I think it’s best not to, for now.


Vertigo, feeling unwell, nausea, etc.

Hey, I'm looking for advice. I'm currently been on dutasteride for 7 months now. It's hard to say if it's helped or not but my hairline seems to be receding. Although my hair seems to look better than when I was on finasteride.

Idk if the receding hairline is from dutasteride shed or just general receding that dutasteride can't prevent. So I'm thinking of adding oral Min and seeing if that will regrow the hairline. Should I add the Min or wait at least 12 months on dutasteride ?

 

[John Difool]

You need to figure out if you are shedding or if the hair that are falling are miniaturizing. Are you diffuse thinner or is your hairline receeding? If you are on Duta and still receeding then you need to up the AA (eg RU) and start microneedling. minoxidil will not stop Androgenetic Alopecia but you can add it topical with the Follica protocol (check other thread). I would add RU to minoxidil both 5%, apply morning and evening then see what's happening.

EDIT: it's not like you just realized you are balding so what was your hair loss pattern before you switch to Duta and how long ago where you on Fina?

 

[pegasus2]

Estrone, Estradiol, and spironolactone

 

[RudaSync]

Estrone, Estradiol, and spironolactone

View attachment 142554

Amazing

 

[DiffuseSucks]

You need to figure out if you are shedding or if the hair that are falling are miniaturizing. Are you diffuse thinner or is your hairline receeding? If you are on Duta and still receeding then you need to up the AA (eg RU) and start microneedling. minoxidil will not stop Androgenetic Alopecia but you can add it topical with the Follica protocol (check other thread). I would add RU to minoxidil both 5%, apply morning and evening then see what's happening.

EDIT: it's not like you just realized you are balding so what was your hair loss pattern before you switch to Duta and how long ago where you on Fina?

My Hairloss pattern is diffuse thinning. I was on finasteride for a year before switching to dutasteride. The first few months my hair felt thicker on dutasteride and hair fall seemed to have dropped a lot. Then I started noticing the hair fall go back to normal, the same amount I'd get when I was on finasteride. The hair I lost on finasteride was mostly thin and small. I've now got similar hair fall on dutasteride. However I've been noticing some thick short hairs as well. and some being less than an inch but look thick. I never took baseline pics of my hairline but it looks like the left side has receded a bit. I'm seeing a lot of baby hairs so it could maybe have been a shed?

 

[John Difool]

Estrone, Estradiol, and spironolactone

View attachment 142554

Curious to see Estrone as part of the regimen since it's less potent than estradiol and its usage is not that popular anymore.

 

[pegasus2]

Curious to see Estrone as part of the regimen since it's less potent than estradiol and its usage is not that popular anymore.

Yes, that caught my interest as well. Oral estradiol is very quickly metabolized to estrone and estriol. Here's the link to that case way back in 1988. https://www.jaad.org/article/S0190-9622(11)01172-8/fulltext

 

[John Difool]

Maybe the study was old (b&w pictures) and by then Estrone was the rage for mtf treatment

 

[Marky]

Amazing

Not that amazing. In the last pic the head is tilted forwad showing the back of the head instead of the top.

 

[John Difool]

That's the type of regrowth I am aspiring to. Then you patch the rest with a FUE and keep all your regrowth with maintenance. Except maintenance may be staying on E bica and AA till death.

 

[Jacob Williams]

I started my new routine trying to combine bicalutamide and CPA to limit side effects about a week ago. Unfortunately delayed shipments have complicated what was supposed to be a more slow and methodical process. I’m almost out of bicalutamide so I’m taking 25mg CPA and 50mg bicalutamide daily for now but soon that’s going to turn into just 25mg CPA daily. I’ve experienced acne, more oily skin, and it seems like my libido is increasing. It’s hard to tell if hair fall has increased as well or if I’m just more paranoid about it. Ever since I cut my hair short my thinning spots have become much more obvious. I’m pretty terrified by these side effects because it makes me think I’m losing ground, but I’m hoping it’s just a phase of adjustment like the one I had when I switched from Spironolactone to bicalutamide monotherapy. Hopefully CPA can give me the results I’m looking for because it’s my last option before I’m forced to start taking estrogen, and I’m not sure I’m willing to do that.

 

[Jacob Williams]

I’m also in disbelief that no AA to date has impacted my extremely oily scalp and awful dandruff. It certainly wasn’t the reason I started more aggressive treatment, but how the hell could 100mg of bicalutamide daily + nizoral not treat my dandruff? My body makes no sense.

 

[Moosey]

I’m also in disbelief that no AA to date has impacted my extremely oily scalp and awful dandruff. It certainly wasn’t the reason I started more aggressive treatment, but how the hell could 100mg of bicalutamide daily + nizoral not treat my dandruff? My body makes no sense.

Thats indeed weird man. but nizoral treats only a special kind of fungus on your scalp (and its side effect which is dandruff). Your dandruff might be happening for a reason not related to a fungus, androgens or oil.

 

[Marky]

It is tilted the same way in the second photo. It's still thicker on the sides, but he has full coverage on top in the last pic. Considering he started at slick bald on 99% of his scalp I think that's amazing. The paper even calls it near full regrowth.

Stop with the nonsense my friend, the red shows what part of his head is in the last photo. He had modest thickening on top with what looks like a bit of a comb over with that clump of hair coming from the right side, but nothing to jump for joy about, like bridgeburn:

 

[John Difool]

Imagine the possibilities of having access to early treatments without waiting for some phase 3 trial results and reporting progress to the community. That's exciting and precu

Pm me if you want to subscribe to my Discord channel.

I started my new routine trying to combine bicalutamide and CPA to limit side effects about a week ago. Unfortunately delayed shipments have complicated what was supposed to be a more slow and methodical process. I’m almost out of bicalutamide so I’m taking 25mg CPA and 50mg bicalutamide daily for now but soon that’s going to turn into just 25mg CPA daily. I’ve experienced acne, more oily skin, and it seems like my libido is increasing. It’s hard to tell if hair fall has increased as well or if I’m just more paranoid about it. Ever since I cut my hair short my thinning spots have become much more obvious. I’m pretty terrified by these side effects because it makes me think I’m losing ground, but I’m hoping it’s just a phase of adjustment like the one I had when I switched from Spironolactone to bicalutamide monotherapy. Hopefully CPA can give me the results I’m looking for because it’s my last option before I’m forced to start taking estrogen, and I’m not sure I’m willing to do that.

I started with spironolactone & CPA while taking E. Then switched to Bica and E. Lost ground, re-added CPA to keep Bica at reasonable daily intake. Now considering going back to spironolactone and keeping CPA.

I don't think Bica worked well for me. If I have to take CPA I may as well use Spyro. Measuring T levels with Bica seems impossible. I also worry that I need to up E & AA too much because of its mechanism.

Has anyone experienced regrowth on Bica. Even @bridgeburn was using Spyro at the beginning and then switched to Bica after regain. Anyone else care to chime in?

 

[pegasus2]

Bica was pretty successful in a small clinical trial of women, but I think @Ikarus is the only one here who has gotten regrowth on bica. Or maybe he got the bulk of his regrowth when he was on spironolactone? For reasons I posted in the estrogen thread, spironolactone just might be superior to bica, and eplerenone might be able to replace spironolactone without the sides.

 

[John Difool]

Bica was pretty successful in a small clinical trial of women, but I think @Ikarus is the only one here who has gotten regrowth on bica. Or maybe he got the bulk of his regrowth when he was on spironolactone? For reasons I posted in the estrogen thread, spironolactone just might be superior to bica, and eplerenone might be able to replace spironolactone without the sides.

Eplerenone looks great but it's not easy to get

 

[Gergely]

would it be beneficial to take CPA once a week, while taking spironolactone and estradiol daily?
edit: (assuming it wouldn't lead to testosterone fluctuation)

 

[John Difool]

If you are going to take CPA do your blood work first and check out your T level and liver to responsibly determine what dose you need if you want to reduce/nuke your T.
Half Life oral elimination is 1.6–4.3 days so instead of taking the med weekly, split each 50mg pill with a pill cutter and use a pill dispenser to hold the bits. Whatever you do don't go excessive. 50mg is max recommendation and it was studied that 12.5mg provides the same benefits.

 

[Gergely]

If you are going to take CPA do your blood work first and check out your T level and liver to responsibly determine what dose you need if you want to reduce/nuke your T.
Half Life oral elimination is 1.6–4.3 days so instead of taking the med weekly, split each 50mg pill with a pill cutter and use a pill dispenser to hold the bits. Whatever you do don't go excessive. 50mg is max recommendation and it was studied that 12.5mg provides the same benefits.

I had it done a bit back, i was on E and spironolactone for 1 month. The only thing that was higher than normal was my bilirubin but that has always been high and in this case it was lower than prior to the meds