Exploring The Hormonal Route. Hair=life.

[mryellowman]

By low dose spironolactone do you mean under 200mg?

Yes. 100 mg was perfectly fine for some guys here. Unfortunately, nobody shares their stories anymore so i don't know how are they going with their hair. Lots of people get success from fina & duta only. Is it so surprising to get results with something like cypro and spironolactone without E ?

Sorry to stray off topic, but do you know if hair shed from letrozole grows back? i was on 2.5mg for two months and lost tons of hair on my crown, i have been off it for just over two months now and no difference, my crown is still a disaster.

You can always regrow hair with right regimen. Letrozole inhibits your estrogen levels so that might be shock loss or loss for shifted hormone levels. Give it some time you will be good.

 

[Guido]

@mellowellowman

Do you think that 25 mg cypro and 125 mg of flutamide could maintain my hair or generate growth?

 

[John Difool]

@Guido are you switching spironolactone for CPA? Why?

 

[Guido]

@John Difool
cyproterone works by lowering LH at the pituitary level in addition to blocking testosterone ... spironolactone only blocks

 

[mryellowman]

@mellowellowman

Do you think that 25 mg cypro and 125 mg of flutamide could maintain my hair or generate growth?

I think finasteride or dutasteride is necassery for maintaining. Consider using minoxidil for regrowth if you are not already using.

 

[Guido]

Do you think that with 25 mg of cypro there are risks of contracting brain tumors?

 

[John Difool]

Of course there is. Even a Diane 35 with a single digits dose has been banned in the US so what do you think? If you know the risks and benefits then the rest is up to you. If you think this is worth the reward then go for it. If not, then try to play safer.

 

[Guido]

@John Difool
I think I'll opt for spironolactone so ... 200mg do you think it will be ok?

 

[John Difool]

And get a blood test so you know what you are dealing with. Right now imagine you are on a golf course blindfolded trying to find the hole. At least blood test results will tell you where the hole is.

 

[Gergely]

should i expect shedding from bicalutamide? is 25mg starter sufficient?
edit: guess i'll find out

 

[Jacob Williams]

should i expect shedding from bicalutamide? is 25mg starter sufficient?
edit: guess i'll find out

I shed like a motherfucker at the start before I stabilized. I also got major sexual side effects, but they actually faded about a month after starting the medication. 25mg is almost definitely not enough to block your T if you aren’t taking estrogen. A normal mono dose would be 100-150mg.

 

[Jacob Williams]

I’ll add my experience on Spironolactone since there seems to be a bit of a debate about that. I was doing 200mg daily, experienced no regrowth but did stop my hairloss for a time. I had no side effects besides a less ejaculate, lower libido, and weaker erections. The problem that I’ve heard a lot of people have with Spironolactone is that you can’t maintain forever on a constant dose. For whatever reason my body needed more and more to do the job that 200mg did originally. 200mg is already a really high dose and you don’t want to push it too far so I dropped it and switched to bicalutamide.

 

[Jacob Williams]

Combining CPA and bicalutamide is asking for failure, they should not be combined at higher doses. 6.25mg of CPA can be done, but any higher has been reported to give androgenic issues by those who have tried to do it.


Maybe seek a therapist first because I remember seeing your ‘hair loss’ and you had none



spironolactone is good for hair regrowth, it’s just not convenient in the long term with how many issues it can cause, especially at the doses needed to deal with hair loss




Your concerns with it were the side effects, in which the sides would go away once stopped because it’s not like 5AR inhibitors. no one knew what sort of outcome it could give with results since the only person who got results back then was Ein. As with every other AA, you cannot use it alone for regrowth, it has to be combined with E and/or oral minoxidil.

I stopped taking bicalutamide and CPA together (my shipment of bica is ridiculously late, probably lost), and am now being forced to transition to CPA monotherapy. Do you think 25mg daily is sufficient? And how much of a shed can I expect? I’m already starting to shed a lot more hair than I usually do but it’s so difficult to distinguish between an “it’s working” shed and an “it’s not working” shed.

 

[Ikarus]

I stopped taking bicalutamide and CPA together (my shipment of bica is ridiculously late, probably lost), and am now being forced to transition to CPA monotherapy. Do you think 25mg daily is sufficient? And how much of a shed can I expect? I’m already starting to shed a lot more hair than I usually do but it’s so difficult to distinguish between an “it’s working” shed and an “it’s not working” shed.

Id go with 50mg/day to start off with, then go down to 25mg of CPA, just in case your T levels are sky high, but that’s just my opinion

 

[Guido]

@Jacob Williams
Did you have an increase in your tits in your diet?

 

[Guido]

@Ikarus

Why is the combination of cypro and bicalutamide a failure? Does Testosterone increase by positive feedback?

 

[Ikarus]

@Ikarus

Why is the combination of cypro and bicalutamide a failure? Does Testosterone increase by positive feedback?

I’m not entirely sure about the scientific stuff behind it, however I’m basing my opinion on someone who had tried higher doses of CPA with bica

 

[Moosey]

Pointless discussions. It doesnt matter wether your block the ARs or wipe out your testosterone. The result is the same. You can have 5000ng/dl in your blood, but when all receptors are blocked by bicalutamide, you will have libido issues nonetheless. And if your dick works despite the absence of androgen-activated AR-activity, then you have alien genetics. Some people can work with low amounts of androgens in the body, but no male can have working erections or libido with zero androgen activity in the body.

Your testosterone levels dont matter, stop looking at them. What matters is AR-activation. Hormones in itself dont do anything until they bind to receptors. Bicalutamide overpowers testosterone and DHT by such a huge magnitude (thousands x times), you will have your desired effects on the hair.
Personally, i would rather block ARs then mess with the testosterone production itself. Your testes have difficulty recovering from a shutdown, evident by what every steroid user experiences. And yes, spironolacton is weak. It has a very low binding affinity. I would use finasteride or dutasteride and bicalutamide. Bica can easily compete with DHT, and much much easier with testosterone.

There is no need whatsoever to mess with your testosterone production. None

 

[Ikarus]

Pointless discussions. It doesnt matter wether your block the ARs or wipe out your testosterone. The result is the same. You can have 5000ng/dl in your blood, but when all receptors are blocked by bicalutamide, you will have libido issues nonetheless. And if your dick works despite the absence of androgen-activated AR-activity, then you have alien genetics. Some people can work with low amounts of androgens in the body, but no male can have working erections or libido with zero androgen activity in the body.

Your testosterone levels dont matter, stop looking at them. What matters is AR-activation. Hormones in itself dont do anything until they bind to receptors. Bicalutamide overpowers testosterone and DHT by such a huge magnitude (thousands x times), you will have your desired effects on the hair.
Personally, i would rather block ARs then mess with the testosterone production itself. Your testes have difficulty recovering from a shutdown, evident by what every steroid user experiences. And yes, spironolacton is weak. It has a very low binding affinity. I would use finasteride or dutasteride and bicalutamide. Bica can easily compete with DHT, and much much easier with testosterone.

There is no need whatsoever to mess with your testosterone production. None

I mean, the main reason why people want to mess with their testosterone levels is due to constantly changing their AAs. No one on this website can seem to stick to one AA, and if they’re using bica alone, there is no going back unless you want to suffer with steroids-like effects...

 

[Ephemeral-Kitten]

I mean, the main reason why people want to mess with their testosterone levels is due to constantly changing their AAs. No one on this website can seem to stick to one AA, and if they’re using bica alone, there is no going back unless you want to suffer with steroids-like effects...

This and because it allows taking a lower dose of bica. I would personally feel safer on 25-50 mg of bica than 100-150 mg.