Exploring The Hormonal Route. Hair=life.

JaneyElizabeth

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EK and KCMB, do you think you can restore a full head of hair without hitting adult female target levels? Just curious but @bridgeburn was sucking on six estradiol pills daily plus estrogel and he used AA's always. My initial quest was to show that topical estrogen on the scalp would restore hair but eh, I am swimming in estradiol after years of low-dose estrogen that went not very far. Oral minoxidil is a Goddess-send too.
 

JaneyElizabeth

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@Bridegeburn's Protocols

I try to re-post these frequently since many people seek proven protocols even though all items in a stack are frequently unnecessary:


@bridgeburn Dosage Recommendations:

I am trying to keep up a bit with @bridgeburn's dosing as we know that it will work. He was taking his estrogen sublingually so that means more or less it is three times as potent but has a shorter half-life from what I have read. This is about at his 9 month mark, I think:

abcnamed said:


hi, may l ask you, what's your final complete regime now?
which kind of estradiol are you using?
ethinyl estradiol ،valerate?! topical or orally or both? in which dose?,
and are you using cyproterone 50 now?
thanks
.5mg Dutasteride
2.25mg oestrogel topically
2mg estradiol hemihydrate, buccally
50mg cyproterone
10mg oral minoxidil, every other day

In terms of strength, this would be a pretty standard male to female HRT protocol for someone well into transition or maintaining adult female target levels except the CPA is off the charts. This is puzzling because he was doing fine without CPA but he might be struggling with the temples. He cut back on the oral minoxidil because someone alleged that that was causing some/much of his growth. I highly doubt this because the growth he has simply doesn't resemble minoxidil hair growth in its pervasiveness. I don't think anyone is claiming that oral minoxidil on its own could do anything close to his gains. He mentions that oral minoxidil has a short half-life so I am not sure why he didn't just go to 2.5mg twice a day.

He explains that he decreased oral minoxidil dosage due to excessive unwanted hair growth.

On August 25th, 2018, this was his regimen:

Second Cocktail in his own words, dating from late summer to fall of 2018:

1mg dutasteride everyday, 6mg buccal estrofem (a couple times i took 8mg but mostly 6mg a day), 200mg spironolactone, 500mg sulfasalizine, 10mg oral minoxidil every other day and topical minoxidil every other day on alternating days (I don't really measure just cover the area). He also was taking 100 mg of progesterone orally which is a marginal dose. October 2nd, he added one Diane pill per week.

All he really needs in my estimation at this point is the 6mg to 8mg estrofem. The oral minoxidil might be important also but that isn't a hormonal med. He shouldn't need oral minoxidil and sulfasalizine, just one or the other from what I have read as long as a person is using topical minoxidil with the sulfasalizine. I think by this point the spironolactone is largely useless as is the dutatsteride but he doesn't know this because he doesn't test so he can't be sure he is hitting targets, perhaps, without an AA.
 

Ephemeral-Kitten

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EK and KCMB, do you think you can restore a full head of hair without hitting adult female target levels? Just curious but @bridgeburn was sucking on six estradiol pills daily plus estrogel and he used AA's always. My initial quest was to show that topical estrogen on the scalp would restore hair but eh, I am swimming in estradiol after years of low-dose estrogen that went not very far. Oral minoxidil is a Goddess-send too.
I think sometimes adult female range E may not be enough. Cis women only really have high E2 for a brief period during the menstrual cycle. Estradiol helps a lot because it boosts SHBG too. In general, cis women have too much testosterone compared to what would be needed to substantially regrow significant loss.
 

JaneyElizabeth

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I think sometimes adult female range E may not be enough. Cis women only really have high E2 for a brief period during the menstrual cycle. Estradiol helps a lot because it boosts SHBG too. In general, cis women have too much testosterone compared to what would be needed to substantially regrow significant loss.
I am coming to that conclusion. There's a reason why cis-guys don't do this. Estrone and Estradiol were discovered around 1930 and people were giving eunuchs estrogen apparently back then so people knew it could regrow hair. But you can't get in and out easily. Noah is trying. I talk a lot about being captured by the experience.
 

keepcoolmybabies

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I'm not sure whether super high E levels provide any greater effect than moderate levels longterm. Estrogen increases the time in anagen phase, so obviously hair will be thicker since more will be growing at any given time. But anytime estrogen levels lower it will cause Telogen Effluvium akin to what happens after pregnancy in women. So unless E lvls stay supraphysiological indefinitely, it might just be temporary improvement
 

JaneyElizabeth

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I am coming to that conclusion. There's a reason why cis-guys don't do this. Estrone and Estradiol were discovered around 1930 and people were giving eunuchs estrogen apparently back then so people knew it could regrow hair. But you can't get in and out easily. Noah is trying. I talk a lot about being captured by the experience.
I was right at the high mark for first trimester pregnancy on my last test so that's where I am keeping things even though my PA said to go back to only one patch. I am not done yet.
 

JaneyElizabeth

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I'm not sure whether super high E levels provide any greater effect than moderate levels longterm. Estrogen increases the time in anagen phase, so obviously hair will be thicker since more will be growing at any given time. But anytime estrogen levels lower it will cause Telogen Effluvium akin to what happens after pregnancy in women. So unless E lvls stay supraphysiological indefinitely, it might just be temporary improvement
No but there was a one person study from 2016 and that drove my conclusions. Once they gave her spironolactone, she had amazing regrowth from bald scalp. She wasn't meeting target levels and they proposed that that is necessary and that's not cheerful news for our cis friends trying to grow hair.
 

JaneyElizabeth

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For anyone else, doctors were not prescribing enough estradiol because they mostly used Premarin or ethinyl estradiol which can eat up the liver long-term but still the women needed to hit target levels. I keep reiterating that I got big boobs from middling estrogen but not the hair. The hair comes last so it's not fair but I don't want to mislead anyone. spironolactone spoofed higher E2 and lower T and she had amazing regrowth. I post it frequently because it is inspired me and then someone told me about @bridegburn.
 

Ephemeral-Kitten

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I don't think too much estrogen is needed to stimulate the stem cells in the follicles, but the fact high E increases SHBG and brings the amount of circulating bio-available androgens way down is more important. Estradiol also down regulates the androgen receptor. So does DHT and testosterone, but obviously we don't want to use those.
 

JaneyElizabeth

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I don't think too much estrogen is needed to stimulate the stem cells in the follicles, but the fact high E increases SHBG and brings the amount of circulating bio-available androgens way down is more important. Estradiol also down regulates the androgen receptor. So does DHT and testosterone, but obviously we don't want to use those.
I need to inform myself some more regarding SHBG. I used the mirror method for so long that like @bridgeburn I never tested because I could tell that I had larger breasts but the hair improvement was only middling. There was some though from Biestro and I posted yesterday how I actually lost hair when I started HRT @.30 mg Premarin because I was slathering Biestro for six months before that. I need to dump my purchase history on my thread and see if I can figure out my possible levels. I mostly quit for two years and I think that helped/caused the breast growth like priming the pump. I tried to be male for her for two more years post-divorce and then I gave up and entered a formal HRT program.
 

JaneyElizabeth

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When my book comes out, you guys might find out just what a nightmare all of this has been with the children and being ghosted and gaslighted by my ex and forced into two facilities for months that were drug clinics and I got no help. She had an intervention for me just so she could snatch the children. Now she gets constant orders because she is uncomfortable seeing me at all. Sigh. So to show some vulnerability, I have been through hell but I mean I think Goddess is about to make things better. I have learned pain and that made me human. No violence--I am a pacifist but my ex has tried to frame things but otherwise, what I have been through is comparable to any Lifetime Movie any of you have ever seen about divorce.

So my big task for today is speaking to the newspaper reporter I have been working with for several months. If I have to do media, Jane needs to be perfect so I am obsessive about that. i also have to write the judge and my ex's lawyer to try to finally quell some of this but our case is like the most litigated case in the history of Maryland.
 

JaneyElizabeth

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What happened to Ikarus and DHTcell, if I may ask?
Ikarus apparently banned himself. It made no sense but I sort of took over this thread in October and then when a couple of folks asked for less trans stuff, I started my own in December and I invited everyone from here. I will help you. 17 is an important point. I can't remember who DHTcell is but I actually have read the entire thread and I have read the first 15 pages over and over. I have never met or interacted with @bridgburn so it might seem strange the way I cite to him but that's how my mind works. We know his protocol works to restore or almost, a full head of hair and we have two years of pics of his. I am trying to do some similar things. I have a picture of myself at 17. Let me find the link.
 
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JaneyElizabeth

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Jane at 17. This is my Rosebud, my lifelong quest to recover:

1612436240687.png
 

JaneyElizabeth

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Here's before I started HRT. Second time in my life where I had gone from at least better than average and I just lost my looks as a male like overnight. I need to update but I have dermatitis pics and hobo hair pics but I need to update. Jane is so classy compared to what Will was and was becoming:


1612436369134.png


This unfortunate person was like in the olden days all used up at 48 and boy, did it come on quick and I guess my maintenance was going away and you can see here the rampant dermatitis. I had no choice except to let Jane out. I don't think anyone can deny that I have had huge regrowth in front of the ears and the temples are coming downward.
 
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