Exploring The Hormonal Route. Hair=life.

Pls_NW-1

Pls_NW-1

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Almas said:
We don't know what doses are needed. We can only speculate. But even if we take DHTcel's calculations (I assume that the dosages are too high), then no one needs more than 100mg. Considering the cost of Bicalutamide 75mg, this is the highest dose I can afford, dividing the 150mg tablet into 2 parts. If 75mg doesn't work for you, you might want to jump on estrogen because the effectiveness of Bicalutamide grows more slowly with increasing dosage.
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Personally, I still want to look like a man and function somewhat so...

I would just wear a system instead of taking estrogens, imo
 
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Almas

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Pls_NW-1 said:
Everybody needs a different dose of bica. some need 50mg, some need 150mg. lol
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As sensitivity to androgens increases with age, in the end everyone will need one dose
Plus, we're talking about a dose that will help everyone. I don't want people to have to wonder if a treatment will work
 
Selb

Selb

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Rather than experiment with oral AAs, I would experiment with topicals. Find one with a short half life and won’t go systemic too much
 
Pls_NW-1

Pls_NW-1

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Selb said:
Rather than experiment with oral AAs, I would experiment with topicals. Find one with a short half life and won’t go systemic too much
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I would prefer ORM topically, but it seems like it doesnt work for everyone. I still try to figure out what its molecule size is. That may be the reason why some get results and some not, it doesnt reach the root because for some the scalp is not able to absorb its size.
 
Pls_NW-1

Pls_NW-1

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Selb said:
Rather than experiment with oral AAs, I would experiment with topicals. Find one with a short half life and won’t go systemic too much
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in 5-10years there will pop up new topical AAs with small molecule size and degrading properties... Cant wait lol
 
Selb

Selb

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Almas said:
And that won't work
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Have you tried it? Order of operations should be finasteride, then dutasteride, then topical AAs. Oral AAs are for the desperate.

And if you’re willing to do bica, then why not use a huge dose of RU instead? You’ll get sides just like you’ll get sides with bica, but at least you have the benefit of not hurting your liver and not upregulating test production if you go off it
 
Pls_NW-1

Pls_NW-1

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Selb said:
Have you tried it? Order of operations should be finasteride, then dutasteride, then topical AAs. Oral AAs are for the desperate.

And if you’re willing to do bica, then why not use a huge dose of RU instead? You’ll get sides just like you’ll get sides with bica, but at least you have the benefit of not hurting your liver and not upregulating test production if you go off it
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I dont think if I am willing to use 250mg RU twice daily :(. Costly. Lol

And the upregulated LH can be counteracted with the use of CPA or E for a month to one and a half before stopping bica so everything goes to baseline again.
 
Pls_NW-1

Pls_NW-1

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Selb said:
Have you tried it? Order of operations should be finasteride, then dutasteride, then topical AAs. Oral AAs are for the desperate.

And if you’re willing to do bica, then why not use a huge dose of RU instead? You’ll get sides just like you’ll get sides with bica, but at least you have the benefit of not hurting your liver and not upregulating test production if you go off it
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But your first words are very true, I just can agree there.

Tho you have to consider that we started balding with the age of 13/14. 5ARi are almost powerless because of the aggressivness.
 
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JaneyElizabeth

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Almas said:
Oh, those Reddit experts ...
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The second point is largely true and what I advise but even 1mg of E2 might be enough. If using SL, though certainly 1 mg daily might be enough as well as 1mg on the Scrotum.

The second point is dead wrong. Again, conceptually what Powers says seems that it might be true but it just isn't true for many people. Search re-masculinization and HRT. I know this myself. DHT does not go into the night even after castration or overall T levels ~0 which is what I have and my dermatitis is back because the oral minoxidil re-invigorates the hair follicles of the beard. Not so much as to cause it to grow but the scratchiness has increased and I have seen touches of dermatitis here and there. DHT is created intracinely and it is unpredictable. I wish it were true about bica or spironolactone and I almost went off duta but I still use .5mg daily. Even estrogel on my face has struggled at times to control dermatitis. People who try to conceptualize about HRT and say prostaglandins or amounts are often wrong which is why I stress again and again from what we know, even tiny amounts of estriol might foment breast growth because tiny amounts start breast growth in pubertal girls.

I have no ax to grind and ultimately people have to try something and stop obsessing. Guys are terrified about all of this and I don't get it because my generation didn't expect sides from finasteride/min and largely we just took them and depended on the pharmaceutical regulatory system which certainly has problems but Min is out now for 40 years and finasteride for almost 20.

I see guys obsessing about T in the front and DHT in the back of the scalp and who cares? Nobody is regrowing hair without increasing their internal E2 levels either by bica perhaps or by adding exogenous E2.
 
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JaneyElizabeth

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Almas said:
Oh, those Reddit experts ...
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Powers won't prescribe reductase inhibitors to men or women as is noted in his debates with Aly from Transfeminine Sciences and she largely wipes the floor up with him. I like him because he spars with his readers and he is fun to watch in his videos but he promotes largely enhanced breast growth without even keeping data on his patients which makes his assertions largely without value. But like with hair gurus, MtF's love breast gurus. And many MtF's <raises hand> do often indicate that E2 levels north of 300 pg/ml induce feelings of well-being and libido that lower levels do not. It can almost be jarring when e2 levels go up dramatically because first libido, especially with an AA, can plunge to nothing but E2 is the libido hormone for women. It's less compulsive than T but the feeling can be, "now where did that "horny-ness" come from all of a sudden?" Women with pregnancy levels of estrogen often indicate extreme horny-ness and it is often mentioned on shows like Sex and the City and often estrogen-friendly programming about pregnancy.

This appears to be true in virtually all females but it might be much more laid back in many mammals as the female awaits the winner of the rut. Some animals like cats which bear litter from multiple input sources though can often have this induced by the act of sex itself as the male cat has an uncomfortable spiked penis that can induce ovulation. That's why they are so noisy because the female cat is not easily tamed during reproductive activities.
 
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