Exploring The Hormonal Route. Hair=life.
- Thread starter bridgeburn
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I said that I had concluded that it was unlikely without exposure to the risk of significant breast growth and complete feminization in terms of restoring signficant patches of scalp with dormant follicles. Only estradiol and its metabolites appear to be able to do this at all and certainly, safely, given current concerns about things like bone density and loss of bone mass not to mention all of the crazy sides coming from CPA, spironolactone and Bica, and that's without delving into the suicide risks of using things save estradiol for regrowth.
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A minute ago you were filling out the forms for castration surgery, lol. 15 years is a step up from that
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I am not going to repeat it, bones, mucles etc depend on AR activation and not on AR signaling. Bica acts as a corepressor and stops AR signaling but not activation. Activation gets actually increased in vitro because sex hormones get doubled or even tripled.
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I am a desperate youngster, what do you expect hahaA minute ago you were filling out the forms for castration surgery, lol. 15 years is a step up from that
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I wrote this to a friend here on the forum and I will repost here it can help some users to understand some concepts.
Testosterone increases / stimulates / creates various body tissues in our entire body.
It is possible to show in the tissues of bald men a great presence of certain types of collagens and inflammatory processes But did it develop before or after the fall? continue , testosterona -DHT (think this DHT stimulates hair growth throughout the body, but it does not happen on the scalp the question is why? ) in scalp DHT start cascate inflamatory thicken the outer layer of the skin by the process of inflammatory fibrosis, and strangle the follicles .
I want you to notice that high levels of testosterone stimulate IGF-1, this can cause certain degrees of low "acromegaly" by changing your cranial and body structure, if you look at our anatomy you can see that we have no muscles in the frontal and upper scalp, note this article that I'll post now
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639964/
You can see that it is connected with the tension exerted by our cranial box and by the muscular stretching and baldness in the male pattern.
Is so many ways , this sh*t is a big sh*t , baldness is Hydra 7 heads of the Greeks
Testosterone affects our bodies in infinite ways, so we see that infinite protocols work for some and not for others , because is more than DHT .
Having said that and knowing what I know, I know that estrogen increases the production of collagens that give quality health to specific skin types(collagen skin types), that testosterone does not check and does not maintain mainteince correctly most of the time, so the body we naturally transform T into E via aromatase for fertility (cels sertoli , cels leydig need this) , and all body need e2 .
However for some reason we lose receptors or create resistance in our E receptors or drop levels of E or maybe our testosterone drops a little bit and it ends up for any reason and our natural conversion to e2 drop, and this is not noticeable in the short term, but in a chronic state our body has physiological changes due to this lack of balance.
What I believe is that for XY the secret is not to block T entirely as TRANS methods as bridge did, he changed his entire endocrine system.
If he stops taking the medication, his life is probably over because he cannot return, he must have developed primary hypogonadism.
I don't think T is our villain, but the hormonal balance,I think the replacement of estrogens in low dose (bi-estro maybe) or stimulates LH for more conversion T -E2 men is essential if you want to maintain health, general condition, youth for health quality in general of the body, all the boys who take HRT if you notice it reach a perfect balance at a certain point of the treatment that is they look like beautiful men, I believe that the fabrics tissues in body still hold the marks of T and when E goes up it gives this appearance "Boy Band", only when they advance their body in the treatment they transform into women totally I believe that this point is where the fabrics tissues become chronicles in E without the presence of T.
I think the secret is the manipulation of the E with its T, and what I can tell you is that in several patients only E is not able to block the production of T, not even! Because this TRANS NEED USE AA , only E not suprimed T (sometimes yes) But I want you to note that progesterone is not always used in transitions I’ve seen complete transitions with AA + e2 and a full head. So it's a matter of adapting your body to "large" amounts of E and T without suppressing its axis maybe use some natural herb to influence LH/FSH at first maybe be a way.
Bicalutamide comes up against a lot of what I said, high testosterone levels influenced IGF-1, and thousands of other things, so bicalutamide is not a right shot in some cases .
I tried to explain as clearly as possible
Testosterone increases / stimulates / creates various body tissues in our entire body.
It is possible to show in the tissues of bald men a great presence of certain types of collagens and inflammatory processes But did it develop before or after the fall? continue , testosterona -DHT (think this DHT stimulates hair growth throughout the body, but it does not happen on the scalp the question is why? ) in scalp DHT start cascate inflamatory thicken the outer layer of the skin by the process of inflammatory fibrosis, and strangle the follicles .
I want you to notice that high levels of testosterone stimulate IGF-1, this can cause certain degrees of low "acromegaly" by changing your cranial and body structure, if you look at our anatomy you can see that we have no muscles in the frontal and upper scalp, note this article that I'll post now
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639964/
You can see that it is connected with the tension exerted by our cranial box and by the muscular stretching and baldness in the male pattern.
Is so many ways , this sh*t is a big sh*t , baldness is Hydra 7 heads of the Greeks
Testosterone affects our bodies in infinite ways, so we see that infinite protocols work for some and not for others , because is more than DHT .
Having said that and knowing what I know, I know that estrogen increases the production of collagens that give quality health to specific skin types(collagen skin types), that testosterone does not check and does not maintain mainteince correctly most of the time, so the body we naturally transform T into E via aromatase for fertility (cels sertoli , cels leydig need this) , and all body need e2 .
However for some reason we lose receptors or create resistance in our E receptors or drop levels of E or maybe our testosterone drops a little bit and it ends up for any reason and our natural conversion to e2 drop, and this is not noticeable in the short term, but in a chronic state our body has physiological changes due to this lack of balance.
What I believe is that for XY the secret is not to block T entirely as TRANS methods as bridge did, he changed his entire endocrine system.
If he stops taking the medication, his life is probably over because he cannot return, he must have developed primary hypogonadism.
I don't think T is our villain, but the hormonal balance,I think the replacement of estrogens in low dose (bi-estro maybe) or stimulates LH for more conversion T -E2 men is essential if you want to maintain health, general condition, youth for health quality in general of the body, all the boys who take HRT if you notice it reach a perfect balance at a certain point of the treatment that is they look like beautiful men, I believe that the fabrics tissues in body still hold the marks of T and when E goes up it gives this appearance "Boy Band", only when they advance their body in the treatment they transform into women totally I believe that this point is where the fabrics tissues become chronicles in E without the presence of T.
I think the secret is the manipulation of the E with its T, and what I can tell you is that in several patients only E is not able to block the production of T, not even! Because this TRANS NEED USE AA , only E not suprimed T (sometimes yes) But I want you to note that progesterone is not always used in transitions I’ve seen complete transitions with AA + e2 and a full head. So it's a matter of adapting your body to "large" amounts of E and T without suppressing its axis maybe use some natural herb to influence LH/FSH at first maybe be a way.
Bicalutamide comes up against a lot of what I said, high testosterone levels influenced IGF-1, and thousands of other things, so bicalutamide is not a right shot in some cases .
I tried to explain as clearly as possible
- Reaction score
- 2,035
I am done with you Almas. Best wishes in your journey. You are on a site that is way more business-like than Rob's and he is a gentleman who attempts to reconcile all of the literature in a way that is concise and convincing. People have to earn a living and his site is free and certainly worth a membership to support him. He answers essentially all email and does so politely and was one of the first mainstream folks to treat HRT as being a complete restoration possibility.
- Reaction score
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This is exactly why I decided not to try Bica, CPA and I ditched spironolactone because I want to show that at least for some, estradiol-only works just as well and much more safely as E is an endogenous hormone that both sexes produce.
My second thesis is that perhaps, mega doses of E2 only can work for virtually everyone for ten months or so, which is the approximate period of pregnancy up to giving birth when estrogen and P4 is often flushed from the system.
Obviously, we will never have research because these drugs are not meant to treat hair loss.
- Reaction score
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I really like your comments, they are empirical, full of experience and emotion, thanks Janey
Let check your thyroid!
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- 1,104
All good.
- Reaction score
- 1,104
@tato123 Bicalutamide monotherapy (no LHRH agonist) does not alter high IGF-1 levels. When used with Tamoxifen it actually decreases IGF-1 by affecting the IGF-1 axis.
When using LHRH+Bicalutamide, Insulin resistance can occur due to high IGF-1 levels and thus lead to diabetes.
But we don't use LHRH agonists, nor do we castrate ourselves.
When using LHRH+Bicalutamide, Insulin resistance can occur due to high IGF-1 levels and thus lead to diabetes.
But we don't use LHRH agonists, nor do we castrate ourselves.
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Yeah, no wonder, high IGF-1 induces Insulin resistance and thus leading to Diabetes.
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This is physiology my friend, it has nothing to do with the medication, high levels of testosterone resulted in high levels of IGF-1, perhaps bicalutamide does not stimulate even more, but I am talking about human physiology
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- 1,104
Oh, ok, sorry then. But yes, we still can't say that Bicalutamide can be taken without any issues, yes.