Exploring The Hormonal Route. Hair=life.

Pls_NW-1

Pls_NW-1

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Gergely said:
I'm basically quitting bica, but only because i'm living like a homeless. I spend all my money on suplements and hrt. My current dose for the past month is 25mg which is barely worth mentioning
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Lol, that sucks. Here you get bica on prescription for 9€ a month... xD
 
Pls_NW-1

Pls_NW-1

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tato123 said:
https://pubmed.ncbi.nlm.nih.gov/7486812/

No worry bro , I like to talk to you, you have an education
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Oh wow thank you for your nice words... :)

Interesting study, what do you think of cycling on and off Cypro 6mg to prevent spiking T? Or how can we deal against spiking T while on Bica!? I mean, we actually need the spiking T, so it can aromatize, but what if the excess T is unhealthy!? As in IGF-1 spikes, as you said...
 
Pls_NW-1

Pls_NW-1

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Gergely said:
It's 36€ here but i can only order one at a time because if the package cast more than 50€ it will get confiscated at the border
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Oh no, why dont you go to a Doctor? Thats too expensive. I wouldnt bother with taking Bica with such a price and such low doses. Bica should be taken at 75-100mg.
 
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JaneyElizabeth

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Pls_NW-1 said:
Everyone should use Bicalutamide.

Just kidding of course...
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I almost used it last summer. Let's not confuse things. For many, it might be a Goddess-sent treatment as some/many MtF's struggle to reach targets. I had noticed that bica appeared to be getting to be a thing in hair loss circles without much support in the accompanying literature as to why it might be superior to spironolactone and CPA.

Note that the majority of hype surrounding bica is not that it is better or safer than MPA, CPA(although bica is safer than CPA and I don't deny that CPA is the worst both long and short-term) or spironolactone. Having said that, many, many folks find CPA to work better for feminization and hair loss than bica, with the same being true for spironolactone. MPA is generally used for theoretical breast completion in MtF's and is less used now for strictly it's AA purposes and at much lower doses relatively. Both MPA and CPA are used for treatment of sexual offenders without ESTROGEN in large doses akin to some of the relative amounts touted on here and they can easily drop T levels by 80 to 95 percent by themselves, shutting off all or most, sexual ideation. So I will try to see if the sex offender literature has any mention of substantial feminization related to massive CPA and MPA dosages to curb "illegal" instincts but I haven't noticed any mention of this in the past.

My belief is that estrogen is not used in these circumstances, potentially for the same reason that folks don't like it on here because somehow estrogen is seen as "less male" than high dosaging of synthetic AA's which tend to be structurally unlike estrogen and more so akin to progesterone analogues and androgens regardless of the effects being substantially the same. Males can't take it psychologically to use estrogen so I propose calling estradiol or its more pertinent metabolites a pro-drug version of T in chemical structure.

The main benefit of bica has nothing to do with the other AA's; it's rather that it is substantially safer and perhaps more effective than flutamide which very few doctors will even prescribe in the U.S. This is one thing holding bica back for sure along with the cost which is maybe $600 a year but I spent three times that on Estrogel so, everything is relative. Except for Estrogel and patches, the other HRT meds tend to be unbranded and even Premarin is dirty-cheap. I also note that in the short-run, we still don't know if bio-identical works better than Premarin for feminization. It might very well not and using Premarin during three years of transition is not akin to using it forever.
 
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Gergely

Gergely

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Pls_NW-1 said:
Oh no, why dont you go to a Doctor? Thats too expensive. I wouldnt bother with taking Bica with such a price and such low doses. Bica should be taken at 75-100mg.
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No chance there's only one endocrinologist in the entire country whose dealing with MTF HRT, and he will not prescribe anything unless you can pass as a girl and live as one for years. 25 mg is sufficient with my dose of e2.
 
Pls_NW-1

Pls_NW-1

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JaneyElizabeth said:
I almost used it last summer. Let's not confuse things. For many, it might be a Goddess-sent treatment as some/many MtF's struggle to reach targets. I had noticed that bica appeared to be getting to be a thing in hair loss circles without much support in the accompanying literature as to why it might be superior to spironolactone and CPA.

Note that the majority of hype surrounding bica is not that it is better or safer than MPA, CPA(although bica is safer than CPA and I don't deny that CPA is the worst both long and short-term) or spironolactone. Having said that, many, many folks find CPA to work better for feminization and hair loss than bica, with the same being true for spironolactone. MPA is generally used for theoretical breast completion in MtF's and is less used now for strictly it's AA purposes and at much lower doses relatively. Both MPA and CPA are used for treatment of sexual offenders without ESTROGEN in large doses akin to some of the relative amounts touted on here and they can easily drop T levels by 80 to 95 percent by themselves, shutting off all or most, sexual ideation.

The main benefit of bica has nothing to do with the other AA's; it's rather that it is substantially safer and perhaps more effective than flutamide which very few doctors will even prescribe in the U.S. This is one thing holding bica back for sure along with the cost which is maybe $600 a year but I spent three times that on Estrogel so, everything is relative. Except for Estrogel and patches, the other HRT meds tend to be unbranded and even Premarin is dirty-cheap. I also note that in the short-run, we still don't know if bio-identical works better than Premarin for feminization. It might very well not and using Premarin during three years of transition is not akin to using it forever.
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The thing why Bica is such a useful treatment for non binaries and hair loss sufferers is, that it doesn't decrease androgens. It actually increases all sex hormones and can give you most-likely an estrogenic profile, while keeping "man-function". Because of that it's as well safe when talking about bone density, muscles, brain function etc. I even think that Finasteride is worse than Bica because finasteride deplets neurotransmitters, not talking about Dutasteride.

I still try to find if Bicalutamide has an effect on the GABA receptor, some experience problems with sleeping etc. Can someone asure this?

@Almas ?
 
Pls_NW-1

Pls_NW-1

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Gergely said:
No chance there's only one endocrinologist in the entire country whose dealing with MTF HRT, and he will not prescribe anything unless you can pass as a girl and live as one for years. 25 mg is sufficient with my dose of e2.
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How much E2 do you take? I forgot you take E2, sorry.
 
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Almas

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Pls_NW-1 said:
The thing why Bica is such a useful treatment for non binaries and hair loss sufferers is, that it doesn't decrease androgens. It actually increases all sex hormones and can give you most-likely an estrogenic profile, while keeping "man-function". Because of that it's as well safe when talking about bone density, muscles, brain function etc. I even think that Finasteride is worse than Bica because finasteride deplets neurotransmitters, not talking about Dutasteride.

I still try to find if Bicalutamide has an effect on the GABA receptor, some experience problems with sleeping etc. Can someone asure this?

@Almas ?
Click to expand...
It seems to be not, at least I can say for sure that I have not heard of such problems. It was on enzalutamide or darolutamide
 
tato123

tato123

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Pls_NW-1 said:
Oh wow thank you for your nice words... :)

Interesting study, what do you think of cycling on and off Cypro 6mg to prevent spiking T? Or how can we deal against spiking T while on Bica!? I mean, we actually need the spiking T, so it can aromatize, but what if the excess T is unhealthy!? As in IGF-1 spikes, as you said...
Click to expand...
I'm collecting data and taking notes, but I think a viable but dangerous therapeutic scheme would be

500mg-1000mg Metformin
0.50 mg - 2mg E2, these levels have already put you in a minimum female range over time, transdermal E2 and in the affected region (avoiding first pass through the liver)
5ar blocker Fine or whichever you do best.
Microneedling to stimulate the creation of new tissue in the fibrous region.

Oral Minoxidil (PGE2 stimulant) (dose divided on the day because of its short half-life)

LH-FSH Natural stimulants (we have many herbs that are proven to stimulate LH and FSH levels)


Some observations

What will happen to my T level?

Finasteride and LH and FSH stimulants kept it "high", as E2 is sure to change it down.

Note that for testicular health we need to maintain our T levels

That would be maintenance.

And maybe 1 CPA cycle per year or 2.

8 weeks on CPA, and small doses of E2 dropped your T by 95%, but every time you may be at risk of primary hypogonadism and infertility, be aware of that or not , maybe all gonna be all right after .

And when you stop the CPA, the e2 will hold your T shot, but I want your T to come back but a little lower, the e2 in low dosages and the LH / FSH put things in order with your t, however we need tests to confirm.


However, all of this is very dangerous and does not guarantee anything, the right thing and you will be able to absorb as much information as possible and set up your own therapeutic scheme.


If that doesn't work, which I think is impossible, bicalutamide + metformin + e2 + minoxidi will definitely be done, but I want you to note that it will take its toll.

Bicalutamida + e2 for 1 year or less = infertility

Put on balance make your choice
 
Pls_NW-1

Pls_NW-1

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tato123 said:
I'm collecting data and taking notes, but I think a viable but dangerous therapeutic scheme would be

500mg-1000mg Metformin
0.50 mg - 2mg E2, these levels have already put you in a minimum female range over time, transdermal E2 and in the affected region (avoiding first pass through the liver)
5ar blocker Fine or whichever you do best.
Microneedling to stimulate the creation of new tissue in the fibrous region.

Oral Minoxidil (PGE2 stimulant) (dose divided on the day because of its short half-life)

LH-FSH Natural stimulants (we have many herbs that are proven to stimulate LH and FSH levels)


Some observations

What will happen to my T level?

Finasteride and LH and FSH stimulants kept it "high", as E2 is sure to change it down.

Note that for testicular health we need to maintain our T levels

That would be maintenance.

And maybe 1 CPA cycle per year or 2.

8 weeks on CPA, and small doses of E2 dropped your T by 95%, but every time you may be at risk of primary hypogonadism and infertility, be aware of that or not , maybe all gonna be all right after .

And when you stop the CPA, the e2 will hold your T shot, but I want your T to come back but a little lower, the e2 in low dosages and the LH / FSH put things in order with your t, however we need tests to confirm.


However, all of this is very dangerous and does not guarantee anything, the right thing and you will be able to absorb as much information as possible and set up your own therapeutic scheme.


If that doesn't work, which I think is impossible, bicalutamide + metformin + e2 + minoxidi will definitely be done, but I want you to note that it will take its toll.

Bicalutamida + e2 for 1 year or less = infertility

Put on balance make your choice
Click to expand...
Yeah if you pair Bica+ e2 you will shut down your testicels totally. E2 should be avoided by cis mens while taking bica, pretty much, yes.
 
tato123

tato123

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CHECK GUYS
Level.png
 
tato123

tato123

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I want you to notice, some patients even with oral e2 2-4mg maintain testosterone levels at almost 500 with finasteride
 
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