Exploring The Hormonal Route. Hair=life.

[Yar]

Всем привет

 

[Pls_NW-1]

I am honestly worried with my hair, it gets downhill pretty fast, damn.

@Yar Also, nice hair!

 

[2TameDHT]

Now that I have a plan in mind: Bica + E2 4mg for the first three months and then E2 6mg^ monotherapy. Now I just want to figure out if progesterone would be a helpful addition later on down the road or if it'd just be superfluous.

Given that my hairloss is genetic, it may just be run of the mill male pattern baldness, the kind of hairloss that could be more surely helped by HRT. But, just to be sure, I will start directing my research into dealing with the backdoor passage ways and how to deal with them. Just in case.

Also, there's the business of explaining this all to the doctor I get.

My goal will be to achieve longer and stronger hair growth, but at the minimum, I'd be fine with having hair long and strong enough to support extensions and various braided styles.

 

[Fuchsilein]

Now that I have a plan in mind: Bica + E2 4mg for the first three months and then E2 6mg^ monotherapy. Now I just want to figure out if progesterone would be a helpful addition later on down the road or if it'd just be superfluous.

Given that my hairloss is genetic, it may just be run of the mill male pattern baldness, the kind of hairloss that could be more surely helped by HRT. But, just to be sure, I will start directing my research into dealing with the backdoor passage ways and how to deal with them. Just in case.

Also, there's the business of explaining this all to the doctor I get.

My goal will be to achieve longer and stronger hair growth, but at the minimum, I'd be fine with having hair long and strong enough to support extensions and various braided styles.

Why do you want to start with bica and then drop it? You can just start at 6mg E. Progesterone is good, it suppresses T production and also competes with AR-receptor and also directly with T for 5a-reductase IIRC.

 

[2TameDHT]

Why do you want to start with bica and then drop it? You can just start at 6mg E. Progesterone is good, it suppresses T production and also competes with AR-receptor and also directly with T for 5a-reductase IIRC.

I have some reservations about how effective monotherapy is.
So, the Bica is to give the E2 an early advantage to take hold against T/DHT.

 

[Ticken]

View attachment 160498

I am honestly worried with my hair, it gets downhill pretty fast, damn.

@Yar Also, nice hair!

For now, you are on oral finasteride only?
Would there be any downside to trying topical finasteride while you wait to start bica?
If your dhea-s is converting to t/dht locally, in hair follicles, it could make sense to also fight the battle topically/locally while you're waiting.

 

[Fuchsilein]

I have some reservations about how effective monotherapy is.
So, the Bica is to give the E2 an early advantage to take hold against T/DHT.

I started on 6mg mono. Most people shouldn't need more than that to suppress HPT axis. Some need 8mg though. with progesterone there shouldnt be need for a blocker at all in any case. But I also grew boobs really quickly. If I could go back I would immediately start with 3mg E, 90mg ralox and 25mg cypro, which is my current dosage.

 

[Pls_NW-1]

Right now, you are on oral finasteride only, while you wait for bica?
Would there be any downside to trying topical finasteride while you wait for a bica prescription?
If your dhea-s is converting to t/dht locally, in hair follicles, it could make sense to also fight the battle topically/locally while you're waiting.

Thats true. And yes. But Finasteride isn´t adressing DHEA-S´s conversation to potent androgens. Or is it!?

 

[2TameDHT]

I started on 6mg mono. Most people shouldn't need more than that to suppress HPT axis. Some need 8mg though. with progesterone there shouldnt be need for a blocker at all in any case. But I also grew boobs really quickly. If I could go back I would immediately start with 3mg E, 90mg ralox and 25mg cypro, which is my current dosage.

I feel as though I may have higher than average T due to genetics.
Though a test would be needed to be sure of that.
Is adding Ralox expensive? Are there added side effects?
Taking too many meds is also a concern for me.

 

[Androgenic Alpaca]

Now that I have a plan in mind: Bica + E2 4mg for the first three months and then E2 6mg^ monotherapy. Now I just want to figure out if progesterone would be a helpful addition later on down the road or if it'd just be superfluous.

Given that my hairloss is genetic, it may just be run of the mill male pattern baldness, the kind of hairloss that could be more surely helped by HRT. But, just to be sure, I will start directing my research into dealing with the backdoor passage ways and how to deal with them. Just in case.

Also, there's the business of explaining this all to the doctor I get.

My goal will be to achieve longer and stronger hair growth, but at the minimum, I'd be fine with having hair long and strong enough to support extensions and various braided styles.

Why do you want to start with bica and then drop it? You can just start at 6mg E. Progesterone is good, it suppresses T production and also competes with AR-receptor and also directly with T for 5a-reductase IIRC.

I have some reservations about how effective monotherapy is.
So, the Bica is to give the E2 an early advantage to take hold against T/DHT.

Consider starting on progesterone plus E2 then switching to E2 monotherapy once your HPG axis is suppressed. Once gonadal production of testosterone stops idk how much benefit progesterone would be

From what I understand progesterone best supresses t production when taken rectally, read up about it on dr powers' subreddit

If you want I guess you could add bicalutamide but it might be unescessary

 

[Androgenic Alpaca]

I feel as though I may have higher than average T due to genetics.
Though a test would be needed to be sure of that.
Is adding Ralox expensive? Are there added side effects?
Taking too many meds is also a concern for me.

Ralox or another serm is pretty much necessary if you want to avoid breast development because you will have breast development to at least some degree if you take estrogen. That's just how it is.

Also to follow up my last post, bicalutamide could be added later if adrenal testosterone production is a problem, backdoor androgen pathway is a problem, or you just have an extreme hypersensitivity to androgens even after HPG axis supression all of these would be pretty rare though

 

[2TameDHT]

Ralox or another serm is pretty much necessary if you want to avoid breast development because you will have breast development to at least done degree if you take estrogen. That's just how it is.

Also to follow up my last post, bicalutamide could be added later if adrenal testosterone production is a problem, backdoor androgen pathway is a problem, or you just have an extreme hypersensitivity to androgens even after HPG axis supression all of these would be pretty rare though

Ralox or another serm is pretty much necessary if you want to avoid breast development because you will have breast development to at least some degree if you take estrogen. That's just how it is.

Also to follow up my last post, bicalutamide could be added later if adrenal testosterone production is a problem, backdoor androgen pathway is a problem, or you just have an extreme hypersensitivity to androgens even after HPG axis supression all of these would be pretty rare though

Breast growth is one thing I could take or leave though I lean towards leave, but I also do like the possibility of facial feminization.
Another reason people take Bica is for penile function. I know Dr Powers sells a T-gel compound to combat penile atrophy, though.

 

[Androgenic Alpaca]

Breast growth is one thing I could take or leave though I lean towards leave, but I also do like the possibility of facial feminization.
Another reason people take Bica is for penile function. I know Dr Powers sells a T-gel compound to combat penile atrophy, though.

What's your reasoning bicalutamide benefiting penile function? The higher levels of testosterone from upregulation? But that shouldn't aid penile function because the higher levels of T will still be blocked from binding to ARs, right? Or am I missing something here

A lot of people actually do maintain penile function on hrt, it just works differently for them then it did before the hrt. Idk maybe hitting different T level targets will affect things differently.

Also, there's always sildenafil (v****)...

 

[2TameDHT]

What's your reasoning bicalutamide benefiting penile function? The higher levels of testosterone from upregulation? But that shouldn't aid penile function because the higher levels of T will still be blocked from binding to ARs, right? Or am I missing something here

A lot of people actually do maintain penile function on hrt, it just works differently for them then it did before the hrt. Idk maybe hitting different T level targets will affect things differently.

Also, there's always sildenafil (v****)...

It's a commonly held belief here and on various HRT related subreddits.

I think some people do maintain penile length and function, but others don't.
From what I've read, the rule of thumb is "use it or lose it." and from my experience, a lot of transwomen prefer not to use it and therefore they lose it and don't really miss it.

 

[Fuchsilein]

I feel as though I may have higher than average T due to genetics.
Though a test would be needed to be sure of that.
Is adding Ralox expensive? Are there added side effects?
Taking too many meds is also a concern for me.

There are possible side effects, but most people I talked to don't actively notice including me. The only side effect I am experiencing is that I have nightmares more often, but I don't know if it really is due to Raloxifene, also their onset coincided with the moment I added it to my routine.

Is it expensive? It depends where you buy. If you buy Evista from Germany, then yeah that's expensive. But there are also cheap generics available. I don't know if I am allowed to link sources.

 

[RStGeorge]

try super low doses of E and taper up slowly if you need to. I have been on 1mg Estradiol and .75mg estrogel for 2 months with no feminization and vellus hairs starting to grow. I am in a similar position where I dont want to feminize

I am similar to you, except I have experienced a lot of nipple pain with no breast growth.

 

[2TameDHT]

There are possible side effects, but most people I talked to don't actively notice including me. The only side effect I am experiencing is that I have nightmares more often, but I don't know if it really is due to Raloxifene, also their onset coincided with the moment I added it to my routine.

Is it expensive? It depends where you buy. If you buy Evista from Germany, then yeah that's expensive. But there are also cheap generics available. I don't know if I am allowed to link sources.

Well, I'm more concerned about the long term effects of taking so many different meds.
At most, I've taken painkillers and anti-biotics temporarily after dental work.

 

[Androgenic Alpaca]

There are possible side effects, but most people I talked to don't actively notice including me. The only side effect I am experiencing is that I have nightmares more often, but I don't know if it really is due to Raloxifene, also their onset coincided with the moment I added it to my routine.

Is it expensive? It depends where you buy. If you buy Evista from Germany, then yeah that's expensive. But there are also cheap generics available. I don't know if I am allowed to link sources.

could you dm your source? I can't find a good source for ralox. Currently buying tamoxifen from adc but I'd like to switch to ralox

 

[Androgenic Alpaca]

Well, I'm more concerned about the long term effects of taking so many different meds.
At most, I've taken painkillers and anti-biotics temporarily after dental work.

I'd think the two potential dangers would be liver damage and completely throwing off your HPG axis. You can get regular liver enzyme tests to check up on your liver. But on the second point, you're going to be completely reconfiguring your endocrine system so it is possible that you will be damaging that long term and that if you discontinue therapy things just won't go back to normal. This is just the danger of such a therapy unfortunately

Dr. Powers insists that the changes are reversible and that full reproductive function can be restored if hrt is discontinued, but idk if that's always the case.

Also consider physiological changes. Hrt will feminize you. That's what it does. You can try and minmize breast growth with SERMs but there will be permanent changes to your appearance. I saw a post on a forum by a MtF person who then destransitioned back to M and he definitely had long term effects of his time on HRT in terms of a more feminine appearance

 

[2TameDHT]

I'd think the two potential dangers would be liver damage and completely throwing off your HPG axis. You can get regular liver enzyme tests to check up on your liver. But on the second point, you're going to be completely reconfiguring your endocrine system so it is possible that you will be damaging that long term and that if you discontinue therapy things just won't go back to normal. This is just the danger of such a therapy unfortunately

Dr. Powers insists that the changes are reversible and that full reproductive function can be restored if hrt is discontinued, but idk if that's always the case.

Also consider physiological changes. Hrt will feminize you. That's what it does. You can try and minmize breast growth with SERMs but there will be permanent changes to your appearance. I saw a post on a forum by a MtF person who then destransitioned back to M and he definitely had long term effects of his time on HRT in terms of a more feminine appearance

For me, facial feminization is more of a feature, as I'm also considering HRT to transition as non-binary.
Noticing my hairloss and the resulting dysphoria is what has brought me to this. I'm actually quite excited about the potential physical changes. It makes me want to adopt a new workout/diet regimen so that I get the best out of it from the neck down.

With that said, I'm wondering about the everyday impact it could have. I mean, I know plenty of trans people who are quite healthy. They exercise, they take care of themselves, they are able to drink on the weekends etc. I'm a pretty healthy person (more or less), so perhaps it won't be too bad with the proper care.

I've read reproductive restoration is about 50/50, give or take. I guess it depends on a bunch of different factors that no one has gotten a good handle on yet.