Exploring The Hormonal Route. Hair=life.

[cetm-419]

"The medical records of patients who underwent radical prostatectomy with ADT were retrospectively reviewed. In all, 221 patients were included in the analysis. Testosterone recovery was defined as supra-castration (SC) (testosterone levels in serum >50 ng/dL) or out of hypogonadism (OH) (>300 ng/dL) after ADT withdrawal.

Patients treated with ADT for ≤18 months recovered to OH in a mean of 6.8 months (74.6%), but patients treated with ADT for >18 months recovered in a mean of 9.7 months (27.5%)".

Factors associated with testosterone recovery after androgen deprivation therapy in patients with prostate cancer - PMC

We investigated factors affecting testosterone recovery after androgen deprivation therapy (ADT) withdrawal in patients with prostate cancer. The medical records of patients who underwent radical prostatectomy with ADT were retrospectively reviewed. ...

www.ncbi.nlm.nih.gov

if you don't abuse hrt (using high doses for more than 18 months) there are good chances that you won't have any problems... the ideal treatment plan is not to use full hrt for more than 12 months; afterwards, with a low dose of bicalutamide + 5ar-inhibition you should be able to maintain the progress you've made; maybe even a really small dose of E2 would solve any health related problems of ADT form bicalutamide.

 

[Almas_NW0]

For many with aggressive baldness bica is more than enough

Successes in aggressive early baldness will not even fit on the fingers of one hand. Besides, I don't remember him helping anyone without E. Dani was successful, but at what age did his baldness start? Success was with Ein with a rather strange pattern of female pattern baldness, and with DHTcel, which outperformed people on HRT, making it hard for me to believe they are real. In the Russian segment, in this thread where I read all the posts, he helped a minority. You are so focused on successful cases, overlooking those who continued to go bald on Bicalutamide.

And you will make this survival bias

And yes, 6 months is the least you should give to a treatment before discarding it.

No, and if elementary logic is available to you, then you should understand this:
If your baldness, your follicle miniaturization continues after the medicine has accumulated in your body and started to do its job, then there is no point in waiting any longer, the negative dynamics will not change. And to notice the negative dynamics, in my experience, three months are enough. Not changing your treatment regimen for half a year if you see continued deterioration is a big folly.
If the drug works for you, you should at least see no progression of miniaturization after the drug has reached its concentrations. Notice I'm not talking about telogen hair loss.
By the way, I have never experienced telogen shedding.

afterwards, with a low dose of bicalutamide + 5ar-inhibition you should be able to maintain the progress

If Bicalutamide didn't stop hair loss before HRT, it won't stop it after HRT when my T and DHT are back. For example, Dutasteride did not stop Noah's baldness before HRT, and after HRT, remaining on it, he began to go bald again. You seem to have a logic problem.

 

[Almas_NW0]

Patients treated with ADT for ≤18 months recovered to OH in a mean of 6.8 months (74.6%)

too long. In addition, no one argues with the fact that a one-time androgen blockade will not cause problems. But I was going to do cycles of HRT every year, and there is no guarantee that the situation will not worsen.

E2 would solve any health related problems of ADT form bicalutamide

Bicalutamide does not have the side effects of ADT associated with a decrease in estradiol levels. If you don't know about it, then I don't know what to talk to you about. I suggest you read wikipedia lol

 

[cetm-419]

first of all, you don't have aggressive baldness... aggressive baldness means reaching an advanced Norwood (3-4) before your 20's. You have diffuse thinning (and not much tbh).

And the information I'm giving you is not drawn out of my own experience or even anecdotal evidence in a forum. You seem to feel like a scientific or researcher when your IDEAS, because that's what they are, are based on your own experience.

our genetic predisposition to hair thinning due to androgens will only progress in the presence of androgens. I don't understand how you can discard such a powerful AA like bicalutamide, just by the 3 months or whatever period of time you were on it.

There is a reason why you have to give at least 6 months to any treatment to evaluate its performance: The hair cycle. 3 months after starting any treatment you may as well be seeing the thinning from the couple of months before starting, caused by the previous presence of androgens.

my thinning was noticeable when I was 16-17.. and finasteride worked for me (at least for maintenance).

you seem to have many problems, but I'm not going to point them out.. Any reasonable person who reads this thread will be able to notice them.

 

[cetm-419]

too long. In addition, no one argues with the fact that a one-time androgen blockade will not cause problems. But I was going to do cycles of HRT every year, and there is no guarantee that the situation will not worsen.


Bicalutamide does not have the side effects of ADT associated with a decrease in estradiol levels. If you don't know about it, then I don't know what to talk to you about. I suggest you read wikipedia lol

bicalutamide still is one strongest forms of ADT. Meaning it has side effects like:

- hot flashes
- decrease of libido
- gynecomastia
- insomnia
- testicular atrophy

if you think wikipedia is solid medical literature, I suggest you watch a couple of conferences regarding this drugs. I doubt you will understand anything like uptodate, lancet or even amboss (real medical literature)

 

[Almas_NW0]

first of all, you don't have aggressive baldness... aggressive baldness means reaching an advanced Norwood (3-4) before your 20's. You have diffuse thinning (and not much tbh).

By aggressiveness of baldness, I mean how easy it is to treat. As a rule, the earlier it starts, the more sh*t you find yourself in. My hair loss started accelerating last year, which is when I switched to HRT.

And the information I'm giving you is not drawn out of my own experience or even anecdotal evidence in a forum

Then I'm waiting for you to study Bicalutamide on young guys < 20 years old, lol

I don't understand how you can discard such a powerful AA like bicalutamide, just by the 3 months or whatever period of time you were on it.

I have not given up on Bicalutamide and have been using it for over a year without a break.

our genetic predisposition to hair thinning due to androgens will only progress in the presence of androgens. I don't understand how you can discard such a powerful AA like bicalutamide, just by the 3 months or whatever period of time you were on it.

On Bicalutamide, I experienced three miniaturization cycles: one month later, 3 months later, and 5 months on (after 3 months I upped the dosage to 100mg). That was enough. Or now you say that it was necessary to wait a year?

you seem to have many problems, but I'm not going to point them out.. Any reasonable person who reads this thread will be able to notice them.

Cool story

 

[Almas_NW0]

E2 would solve any health related problems of ADT form bicalutamide.

- hot flashes
- decrease of libido
- gynecomastia
- insomnia
- testicular atrophy

So you think that estradiol can help with these effects that bicalutamide causes?

 

[cetm-419]

sure.. insomnia, hot flashes, fatigue / weakness.

and the biggest benefit of adding e2 to a maintenance treatment using bicalutamide is being able to lower the dose of bica. And thus, decreasing the negative effects to the liver.

Of course you would have to either get gyno surgery or not care.

but you are stuck with hrt cycles, so it doesn't matter.

 

[Almas_NW0]

insomnia, hot flashes, fatigue / weakness

I think these effects are usually seen in older people with prostate cancer. The thing is, I haven't heard of anyone experiencing side effects related to weakness, poor sleep, or anything else. Maybe Dani, I don't remember well. The fact is that Bicalutamide does not reduce hormone levels, and side effects such as weakness, drowsiness are usually characteristic of a decrease in hormone levels. For me, this is something from the category of semi-mythical PFS from Finasteride. But to be honest, I'm generally not susceptible to side effects.
This is largely due to the fact that I am not subject to the placebo effect and do not attribute every ailment to the medication. It's also funny when people who reduce the dosage of any drug claim that it immediately relieved them of side effects, but the half-life of their drugs is too long to be able to feel the change in dosages in less than a few weeks.
Of course, I do not deny the possibility of side effects: we react to drugs in different ways. But I always treat claims of side effects such as weakness with a grain of salt, because such a side effect cannot be verified in any way, and it is often caused by the patient's hypochondria, and may be psychosomatic in nature.

and the biggest benefit of adding e2 to a maintenance treatment using bicalutamide is being able to lower the dose of bica. And thus, decreasing the negative effects to the liver.

I think the negative effects of Bicalutamide on the liver are overrated. If you're fine for half a year, I don't think you have anything to worry about.
I don't see the point of adding small doses of E to Bicalutamide, because in my case it won't stop the hair loss and doesn't eliminate the side effects of E. In short, I get the effects of HRT while continuing to go bald lol. I prefer to either use E fully in HRT, or not use it at all.

 

[Almas_NW0]

By the way, now I feel a little lethargic and sleepy because I stopped taking E, and now I have low levels of E and T. This side effect of stopping HRT was also mentioned by Noah. When my t grows up (I'm thinking of raising it with clomid to make it happen faster), this will stop.
However, I'm not entirely sure that the reason is the abolition of HRT: now my sleep pattern is disturbed, and I often sleep too little.

 

[Adri23]

How do you guys manage not to get sides effects on oral bica? I'm using topical bica twice a week and I'm about to die... Chest pain, headache, lower back pain, shortness of breath.... even lung aches from time to time..

 

[Almas_NW0]

How do you guys manage not to get sides effects on oral bica? I'm using topical bica twice a week and I'm about to die... Chest pain, headache, lower back pain, shortness of breath.... even lung aches from time to time..

This is strange. I haven't heard about Bik's side effects anywhere other than this forum: even in cancer patients, side effects are extremely rare and not so significant, and I haven't heard anything from transgender people at all. Are you sure it's Bicalutamide?

 

[Mr. Slap Head]

This is strange. I haven't heard about Bik's side effects anywhere other than this forum: even in cancer patients, side effects are extremely rare and not so significant, and I haven't heard anything from transgender people at all. Are you sure it's Bicalutamide?

I think he is on estradiol and I think that is primarily responsible. He should reduce the frequency of dosage since it has a pretty long half life

 

[Almas_NW0]

I think he is on estradiol and I think that is primarily responsible. He should reduce the frequency of dosage since it has a pretty long half life

On estradiol, such side effects should not occur at all. Otherwise, women's and MTF lives would be hell.
Perhaps he uses low doses of E, which puts him in the middle between hormones. But even then, he shouldn't feel so bad. Now I am in a hormonal deficiency and the worst thing I feel is a little drowsiness

 

[Adri23]

This is strange. I haven't heard about Bik's side effects anywhere other than this forum: even in cancer patients, side effects are extremely rare and not so significant, and I haven't heard anything from transgender people at all. Are you sure it's Bicalutamide?

I'm 100% sure it is bicalutamide. I stopped oral minoxidil the days I use bica to check if it was minoxidil side effect, but I still have the side effects without using minoxidil. It is weird because I only have these side effects hours after application and the day after, the rest of the days, I don't have side effects at all.

 

[Adri23]

On estradiol, such side effects should not occur at all. Otherwise, women's and MTF lives would be hell.
Perhaps he uses low doses of E, which puts him in the middle between hormones. But even then, he shouldn't feel so bad. Now I am in a hormonal deficiency and the worst thing I feel is a little drowsiness

I'm using a weak estradiol, I don't think it is the culprit.

 

[Almas_NW0]

I'm 100% sure it is bicalutamide. I stopped oral minoxidil the days I use bica to check if it was minoxidil side effect, but I still have the side effects without using minoxidil. It is weird because I only have these side effects hours after application and the day after, the rest of the days, I don't have side effects at all.

When I used retinoids, I began to have problems with well-being, weakness. I blamed the accutane for this. But now I understand that it was a coincidence. Who knows, maybe you have an individual intolerance. But how bicalutamide can cause lower back pain is a mystery to me.

 

[Adri23]

When I used retinoids, I began to have problems with well-being, weakness. I blamed the accutane for this. But now I understand that it was a coincidence. Who knows, maybe you have an individual intolerance. But how bicalutamide can cause lower back pain is a mystery to me.

I think is not only lower back pain, it is muscle pain all over my body, but it get worse on that zone. That pain reminds me to the pain you feel days after working out when you haven't moved in a long time. I came to the conclusion I have an individual intolerance, because in the first application I got dizziness and headache right after, and that's cannot be normal.

 

[DoctorHouse]

This thread is looking more like the Midnight classic the Rocky Horror Picture show. Let's all do the Time Warp again........ It's just a jump to your left.............................................off the cliff...........................

 

[Adri23]

Are you transitioning?good for you!!!

You wanna be a trannie? Just tell us already.