Exploring The Hormonal Route. Hair=life.

Aleksey(Aleks)

Aleksey(Aleks)

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Is it dangerous to take Dutasteride (0.5 mg per day, or half a tablet of 0.25 mg per day,)? Who took it, what happened to you, did it help, is there any change, does it make sense?

Started to use Estrogel 1 press (≈0.75 mg per day) topically, to Kirkland Minoxidil foam 2 times a day.

I think it is better to order and use Maxogen-X (1 time a day + Estrozhel 1 time a day and not drink these pills? )

Composition of Maxogen-X:

Minoxidil 7.0% (70 mg*)
Finasteride 0.15% (1.5 mg *)
Azelaic acid 1.5% (15 mg *)
ABN ComplexTM 0.8% (8.0 mg *)
Retin-A (otherwise known as tretinoin) ...... 0.025% (0.25 mg *)
Fluocinolone ........... 0.01% (0.1 mg *)
Caffeine: ............. 0.001% (0.01 mg *)
(* amount in each milliliter (ML))

Plus ketoconazole shampoo (ketoconazole 2% + zinc pyrithione), what do you think?
 
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dar3k

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How much E2 is needed to suppress T to female range while taking 50-100mg Bicalutamide?
 
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S7E841

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Before this I was taking stable Cyprus12.5mg Finasteride 2.5mg and Minoxidil 8mg I was so I was looking for regrowth and I changed therapy ... my therapy for a month is now composed of: dutasteride 0.5mg- bicalutamide100mg-minoxidil oral and lotion with 12 mg-dutasteride 0.5 g and estradiol Topic 0.001 g. These are my blood tests .. and I wonder how it is possible to have a dht so high despite the topical and oral dutasteride in my regime?
I ask for advice because unfortunately my situation is getting worse despite the treatment I am using ... I hope you can help me thanks.

26/04/2022
Exam description Result Reference values

ALBUMINEMIA ........................ 4.60 3.2-4.8 g / dl U
Method: CHEMICAL

TESTOSTERONE ....................... 7.97 Male: 1.75 - 7.81 ng / ml M
Method: ELECTRO-CHEMILUMINESCENCE RESULT CONFIRMED AFTER REPEAT Female: <0.1 - 0.75 ng / ml

FREE TESTOSTERONE .................. 11.49 Man <12 years 0-4.6 pg / ml U
Method: ELISA Male> 12 years 0.18-28.8 pg / ml
Woman 0-2.85 pg / ml

FSH (ECL) .......................... 18.86 Male: 1.4-18.1 mIU / ml U
Method: CHEMILUMINESCENCE Woman: foll.2.5-10.2 ovul.3.4-33.4
lutein. 1,5-9,1 menop. 23,0-116,3

LH (ECL) ........................... 30.40 Man: 1.5-9.3 mIU / ml U
Method: CHEMILUMINESCENCE Woman: foll. 1.9-12.5 ovul.8.7-76.3
lutein. 0.5-16.9 menop.7.9-53.8

PROLACTIN (ECL) ................... 14.74 Man: 2.1-17.7 ng / ml Woman: 2.8-29.2 U
Method: CHEMILUMINESCENCE pregnancy: 9.7 -208.5 ng / ml
menopause: 1.8-20.3 ng / ml

E2-17 BETAHEXTRADIOL ................ 54.03 Man: <39.8 pg / ml U
Method: CHEMILUMINESCENCE Woman: foll.19.5-144.2 ovul.63.9-357
lutein.:55.8-214.2 menop.:<32.2

DHT-DIIDROTESTOSTERONE ............. 543.00 Man: 250-990 pg / ml A
Method: ELISA Premenopausal woman: 24-368 pg / ml
Postmenopausal woman: 10-181 pg / ml

SHBG ............................... 35.58 Male: 14.55 - 113.13 nmol / L A
Method: ELECTRO-CHEMILUMINESCENCE Premenopausal woman: 10.84-> 180
Postmenopausal woman: 23.15-159.07
 
tato123

tato123

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S7E841 said:
Before this I was taking stable Cyprus12.5mg Finasteride 2.5mg and Minoxidil 8mg I was so I was looking for regrowth and I changed therapy ... my therapy for a month is now composed of: dutasteride 0.5mg- bicalutamide100mg-minoxidil oral and lotion with 12 mg-dutasteride 0.5 g and estradiol Topic 0.001 g. These are my blood tests .. and I wonder how it is possible to have a dht so high despite the topical and oral dutasteride in my regime?
I ask for advice because unfortunately my situation is getting worse despite the treatment I am using ... I hope you can help me thanks.

26/04/2022
Exam description Result Reference values

ALBUMINEMIA ........................ 4.60 3.2-4.8 g / dl U
Method: CHEMICAL

TESTOSTERONE ....................... 7.97 Male: 1.75 - 7.81 ng / ml M
Method: ELECTRO-CHEMILUMINESCENCE RESULT CONFIRMED AFTER REPEAT Female: <0.1 - 0.75 ng / ml

FREE TESTOSTERONE .................. 11.49 Man <12 years 0-4.6 pg / ml U
Method: ELISA Male> 12 years 0.18-28.8 pg / ml
Woman 0-2.85 pg / ml

FSH (ECL) .......................... 18.86 Male: 1.4-18.1 mIU / ml U
Method: CHEMILUMINESCENCE Woman: foll.2.5-10.2 ovul.3.4-33.4
lutein. 1,5-9,1 menop. 23,0-116,3

LH (ECL) ........................... 30.40 Man: 1.5-9.3 mIU / ml U
Method: CHEMILUMINESCENCE Woman: foll. 1.9-12.5 ovul.8.7-76.3
lutein. 0.5-16.9 menop.7.9-53.8

PROLACTIN (ECL) ................... 14.74 Man: 2.1-17.7 ng / ml Woman: 2.8-29.2 U
Method: CHEMILUMINESCENCE pregnancy: 9.7 -208.5 ng / ml
menopause: 1.8-20.3 ng / ml

E2-17 BETAHEXTRADIOL ................ 54.03 Man: <39.8 pg / ml U
Method: CHEMILUMINESCENCE Woman: foll.19.5-144.2 ovul.63.9-357
lutein.:55.8-214.2 menop.:<32.2

DHT-DIIDROTESTOSTERONE ............. 543.00 Man: 250-990 pg / ml A
Method: ELISA Premenopausal woman: 24-368 pg / ml
Postmenopausal woman: 10-181 pg / ml

SHBG ............................... 35.58 Male: 14.55 - 113.13 nmol / L A
Method: ELECTRO-CHEMILUMINESCENCE Premenopausal woman: 10.84-> 180
Postmenopausal woman: 23.15-159.07
Click to expand...

Hello, how are you? I was passing through.

You are on a regimen composed basically of Dutasteride and Bicalutamide, these estrogen levels do not make much difference in your body systematically, as your clinical exams show, Your SHBG shows me that you have low circulating estrogen. You have values within the normal range of testosterone and high levels of FSH LH hormones that signal production testosterone hormone for the testes.

We talked a lot about this here in the past, this topic already has more than 1000 pages, and I think that all knowledge is already there, at least from what we have available today, we have exhausted the literature here.


You by nature are XY, your body has AR receptors, and adaptations of your own sex to maintain your perfect homeostasis.

You are on a testosterone spike as dutasteride and bicalutamide raise your basal testosterone level, as DHT does not bind to the receptor due to the drugs the body understands it has no DHT because it has no testosterone and starts FSH-LH-Testosrone FEEDBACK.

All this hormonal medication is a test in the dark, it will vary for each patient, we are talking about the currents that control your body, and we are dealing with them, this is very dangerous, blocking your AR receptors completely can cause death, yes it is serious, but I think you all know what you're doing.


Your regimen needs a dose of estrogen to suppress your endogenous testosterone production, as you are on this route.

You have testosterone spikes and your body is transforming into DHT in the same way, the correct thing would be to increase the dose of duta, but I wouldn't do that, it will increase your testosterone levels even more, and there will be patients who will present the same , a paroxysmal hyperandrogenicity, ie even taking 5ar inhibitors (finasteride and dutastaride) will have such large peaks of testosterone that the body adapts to continue producing DHT.

The correct way to zero your DHT is with estrogen levels.

But that's a complete TRANS MTF scheme, and even then you might not get the result. But you can try.

I have never seen recovery with BICA and finasteride or dutasteride alone. Just an Indian wearer, only he was never bald, it was like maintenance.

Apart from this Indian, who has never been bald and there has been no regrowth, all users of bicalutamide who have had results have been in conjunction with another drug of estrogenic or prostagenic origin. I've been on this forum for a long time, and I've used bicalutamide alone as finasteride as well as several others from my time, it didn't work.

But you can try, why not.
 
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S7E841

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tato123 said:
Hello, how are you? I was passing through.

You are on a regimen composed basically of Dutasteride and Bicalutamide, these estrogen levels do not make much difference in your body systematically, as your clinical exams show, Your SHBG shows me that you have low circulating estrogen. You have values within the normal range of testosterone and high levels of FSH LH hormones that signal production testosterone hormone for the testes.

We talked a lot about this here in the past, this topic already has more than 1000 pages, and I think that all knowledge is already there, at least from what we have available today, we have exhausted the literature here.


You by nature are XY, your body has AR receptors, and adaptations of your own sex to maintain your perfect homeostasis.

You are on a testosterone spike as dutasteride and bicalutamide raise your basal testosterone level, as DHT does not bind to the receptor due to the drugs the body understands it has no DHT because it has no testosterone and starts FSH-LH-Testosrone FEEDBACK.

All this hormonal medication is a test in the dark, it will vary for each patient, we are talking about the currents that control your body, and we are dealing with them, this is very dangerous, blocking your AR receptors completely can cause death, yes it is serious, but I think you all know what you're doing.


Your regimen needs a dose of estrogen to suppress your endogenous testosterone production, as you are on this route.

You have testosterone spikes and your body is transforming into DHT in the same way, the correct thing would be to increase the dose of duta, but I wouldn't do that, it will increase your testosterone levels even more, and there will be patients who will present the same , a paroxysmal hyperandrogenicity, ie even taking 5ar inhibitors (finasteride and dutastaride) will have such large peaks of testosterone that the body adapts to continue producing DHT.

The correct way to zero your DHT is with estrogen levels.

But that's a complete TRANS MTF scheme, and even then you might not get the result. But you can try.

I have never seen recovery with BICA and finasteride or dutasteride alone. Just an Indian wearer, only he was never bald, it was like maintenance.

Apart from this Indian, who has never been bald and there has been no regrowth, all users of bicalutamide who have had results have been in conjunction with another drug of estrogenic or prostagenic origin. I've been on this forum for a long time, and I've used bicalutamide alone as finasteride as well as several others from my time, it didn't work.

But you can try, why not.
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hello friend, I was hoping so much for your intervention ... yes I know, estrogen plays the game here .. but it's hard to commit to those. i know what we are talking about because i have tried androcur and estrogen in the past but i stumbled terribly. however i ordered oestrogel soon it should arrive so by now i'm in it .. again. I tried to ask several users for advice here also to maybe try topical bica or ru, but in the end I understand that without all these drugs just play with estrogen dosages and understand what you are doing. I understand that all these drugs can cause me problems in the future .. but I think the present is more important. I have two questions for you?! I remember you too had high dht levels from exams .. right? and the other thing is how exactly did you dose your estrogel without running into side effects? thanks for your advice
 
tato123

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Well, let's go.

You're right who plays the game are the hormones of female origin, but understand that playing this game is like you said "Difficult".
And I understand you perfectly, I've walked this path and I know what you mean and I know how your baldness must bother you. I'm here to understand and help the choice and consequence is always yours.

I used estrogen at a dosage of 0.25 to 0.75-1.25mg 3 days week, sometimes all days, with bicalutamide, with CPA, but I was on E2 longer alone.

In the end I stopped taking all antiandrogenics, finastaride too, I was only on E2 gel (oestrogel) Cycle it during the year, I stayed from 2019 to 2021 December. at low dosages, controlled with blood tests, I always stayed within the normal range of testosterone.

When I had increased DHT I increased my E2 and SHBG levels.

But this is all very dangerous, I started to notice side effects with these doses of E2, loss of sexual potency was the main one, I started to feel it around 1 year of treatment and then it only got worse, even with normal levels of Testosterone. I want to point out that E2 is part of the male libido, but from the moment you use it exogenously and without sense, Lose that delicate control.

Better skin and hair quality. For sure. But to say that I got massive regrowth is not true. The effect is limited, and I'd say some wouldn't even notice any different effect.

What I had the most result was in a cycle of immunosuppression and steroids(prednisolone), my hair grew like crazy, but I had another health problem I didn't use it because of baldness. Here is Much more effective than the hormonal route, but much more dangerous.

I wonder the real mechanism of action of baldness, maybe the hormonal route is secondary to the real problem. But altering your immune system is very dangerous.All we have are theories, such as the galea theory, or the skull shape and bla bla bla, but in all of them it is possible to evidence the immunological role
See Cyclosporine A.

But this sexual route is the most promising("safety" or more "safety"), perhaps the female profile (immunological, skin, body composition) is responsible for the result, and until this profile is reached, it will be very difficult to have regrowth and true density with a men body.

Perhaps a strange combination of immunology, genetics and secondarily hormonal profiling may be involved. That's why the hormonal approach almost never has a satisfactory effect, perhaps it's not the root of the matter.


You need low doses of E2, start with a little and titrate upwards. And good luck, it might work. Focus faith force
 
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S7E841

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tato123 said:
Bene, andiamo.

Hai ragione chi fa il gioco sono gli ormoni di origine femminile, ma capisci che giocare a questo gioco è come hai detto tu "difficile".
E ti capisco perfettamente, ho percorso questa strada e so cosa intendi e so quanto la tua calvizie debba infastidirti. Sono qui per capire e aiutare la scelta e la conseguenza è sempre tua.

Ho usato estrogeni a un dosaggio da 0,25 a 0,75-1,25 mg 3 giorni a settimana, a volte tutti i giorni, con bicalutamide, con CPA, ma ero solo su E2 più a lungo.

Alla fine ho smesso di prendere tutti gli antiandrogeni, anche la finastaride, ero solo su gel E2 (oestrogel) Ciclalo durante l'anno, sono rimasto dal 2019 al 2021 dicembre. a bassi dosaggi, controllati con esami del sangue, sono sempre rimasto nel range di normalità del testosterone.

Quando ho aumentato il DHT, ho aumentato i miei livelli di E2 e SHBG.

Ma tutto questo è molto pericoloso, ho iniziato a notare effetti collaterali con queste dosi di E2, la perdita di potenza sessuale era la principale, ho iniziato a sentirla intorno a 1 anno di trattamento e poi è solo peggiorata, anche con livelli normali di Testosterone. Ci tengo a sottolineare che l'E2 fa parte della libido maschile, ma dal momento in cui lo usi in modo esogeno e senza senso, perdi quel delicato controllo.

Migliore qualità della pelle e dei capelli. Di sicuro. Ma dire che ho avuto una ricrescita massiccia non è vero. L'effetto è limitato e direi che alcuni non noteranno nemmeno alcun effetto diverso.

Quello che ho avuto il maggior risultato è stato in un ciclo di immunosoppressione e steroidi (prednisolone), i miei capelli sono cresciuti come un matto, ma ho avuto un altro problema di salute che non l'ho usato a causa della calvizie. Qui è molto più efficace della via ormonale, ma molto più pericolosa.

Mi chiedo il vero meccanismo d'azione della calvizie, forse la via ormonale è secondaria al vero problema. Ma alterare il tuo sistema immunitario è molto pericoloso. Abbiamo solo teorie, come la teoria della galea, o la forma del cranio e bla bla bla, ma in tutte è possibile evidenziare il ruolo immunologico
Vedi Ciclosporina A.

Ma questa via sessuale è la più promettente ("sicurezza" o più "sicurezza"), forse il profilo femminile (immunologico, pelle, composizione corporea) è responsabile del risultato, e fino a quando non sarà raggiunto questo profilo sarà molto difficile avere ricrescita e vera densità con un corpo maschile.

Forse potrebbe essere coinvolta una strana combinazione di immunologia, genetica e profilazione ormonale secondaria. Ecco perché l'approccio ormonale non ha quasi mai un effetto soddisfacente, forse non è la radice della questione.


Hai bisogno di basse dosi di E2, inizia con un po' e aumenta il titolo. E buona fortuna, potrebbe funzionare. Concentra la forza della fede
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thank you very much friend for your availability, I have read the whole discussion twice, but in the end your path seemed to me the most suitable for a man who wants to take risks .. and honestly in my opinion you have had excellent results with low dosages. I think the hormonal path is very effective, unfortunately if you want to remain men or at least half men you can't go easy with this .. when i was on androcur and oral E2 i saw hair grow that wasn't there for at least 15 years, but then I had a real nervous breakdown .. that being a man cannot be accepted. it would not make sense.I have been fighting this battle for a long time ... until one day I came across this forum without participating however ... it was 2017 and I started taking spironolactone until 2020 and it gave me excellent maintenance, unfortunately then I discovered this discussion and everything went to get fucked up .. I say so because maybe today I was still on spironolactone without problems and instead in 2020 I started cyproterone for 8 months in mono therapy with good results .. but I wanted more, and I added oral E2 and minoxidil oral 5mg. the hair started growing but one fine day I notice that my penis has shrunk in size and this can't go for a man. so from that day it is an exhausting battle but without E2 it seems that nothing works for me anymore .. sorry for the digression it was to point out that I know the medicines and their effects ... I keep asking you questions if you don't mind ?! I also need to understand how far it can go by measuring estrogen. are you still being treated today? have you lost your earnings? What role do you give to bicalutamide, metformin in the treatment? Thanks again.
I apologize if some words seem out of place but I write with the translator ..
 
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Adri23

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Itsnoahkennedy said:
I stopped minoxidil a long while ago i don't tolerate it well, crazy heart palpitations when doing simple tasks felt like i was gonna faint from exhaustion, probably low blood pressure.

From a group buy we all pitched in $38k combined to have it synthesized from the patent in late 2021 / early 2022.
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Unlucky with minoxidil... Do you think pyri is being effective or it is RU or both? I have much hope on pyri.
 
Adri23

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Itsnoahkennedy said:
Ive been on RU for 4 months and Pyrilutamide for 1 months so I'd say both. Pyrilutamide is 4x stronger than RU and a bit stronger than DHT, so it overpowers DHT at the follicle.
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I have more hope now that some people here are having results. Which vehicle are you using?
 
Adri23

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Itsnoahkennedy said:
Kintor uses a 70%:30% of Ethanol: PG so that's what i use, mixing 150mg in a 60ml solution for 2.5mg per ml, i gotta use 4ml a day to cover my scalp.
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Aren't they using a gel solution?
 
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Adri23

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Itsnoahkennedy said:
Yeah i do 100mg RU58841 at night and 10mg Pyrilutamide in the morning.
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Do you think I should use 100 mg split in 2 doses if I'm not using pyri? Ex: 12.5mg/ml 4 ml morning and 4 ml night.
 
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