Exploring The Hormonal Route. Hair=life.

Adri23

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Everything is a lottery on hrt, but i got the worst combo possible, big breast with 0 hair gains and still losing
 

sg2000

Experienced Member
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Everything is a lottery on hrt, but i got the worst combo possible, big breast with 0 hair gains and still losing
wtf have you checked something else that cab cause this shed of yours?I cant find an explanation is it androgenetic alopecia or not?
 

Adri23

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wtf have you checked something else that cab cause this shed of yours?I cant find an explanation is it androgenetic alopecia or not?
Everything went downhills after the dht spike, my hair has never been the same till then, all points to Androgenetic Alopecia cause I have only 1 hair per shaft and different thickness (mostly miniaturized), that is what you see on Androgenetic Alopecia
 

Almas_NW0

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Dutasteride doesn't work without full stack transgender regimen, Unless you are a typical Asian who is hyper responder to micro dose of finasteride, otherwise you need to embrace your feminine side and start taking your Estrogen like a good girl. I'm saying it explicitly as cis male.
It's a stereotype that Asians respond well to treatment, just like it is that they don't go bald. I am an Asian who started going bald at 16 and for whom RU + Duta + Bicalutamide did not work.
 

sg2000

Experienced Member
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320
Everything went downhills after the dht spike, my hair has never been the same till then, all points to Androgenetic Alopecia cause I have only 1 hair per shaft and different thickness (mostly miniaturized), that is what you see on Androgenetic Alopecia
how could so little dht cause this much damage ?Isnt e2 suppress all T?So where the f*** is this damn dht produced?
 

Adri23

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how could so little dht cause this much damage ?Isnt e2 suppress all T?So where the f*** is this damn dht produced?
Mostly 5ar1 prob. The thing is after a full month on dutasteride I dont see any single strand of hair growing under trichoscope, I expected at least few dots of thick hair growing but nothing but miniaturization
 

sg2000

Experienced Member
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It's a stereotype that Asians respond well to treatment, just like it is that they don't go bald. I am an Asian who started going bald at 16 and for whom RU + Duta + Bicalutamide did not work.
lookin at adris case it seems hrt isnt the cure we all tought about
 

sg2000

Experienced Member
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Mostly 5ar1 prob. The thing is after a full month on dutasteride I dont see any single strand of hair growing under trichoscope, I expected at least few dots of thick hair growing but nothing but miniaturization
yes but how even half 5ar1 can cause this damage? so 0.5 dutasteride is sh*t and tyhe biggest scam ever
 

Adri23

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lookin at adris case it seems hrt isnt the cure we all tought about
Well i guess im just unlucky, but im not certainly sure if estradiol alone regrow hair on many ppl tho, usually minoxidil paired with e2 + dutasteride is what causes the best regrowth in my opinion
 

Adri23

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yes but how even half 5ar1 can cause this damage? so 0.5 dutasteride is sh*t and tyhe biggest scam ever
Upregulation prob, it only happened after i got on daily bicalutamide. Thing is the upregulation never went away, I'm waiting for my december blood test to confirm my dht is really lower
 

sg2000

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Well i guess im just unlucky, but im not certainly sure if estradiol alone regrow hair on many ppl tho, usually minoxidil paired with e2 + dutasteride is what causes the best regrowth in my opinion
are you on minoxidil too?
 

losingbattle88

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Upregulation prob, it only happened after i got on daily bicalutamide. Thing is the upregulation never went away, I'm waiting for my december blood test to confirm my dht is really lower
What I dont understand is that it seems that most ppl get watery semen to some extent from finasteride or dutasteride. But on 2.5mg dutasteride my semen was unchanged or even thicker hmmm.
 

Adri23

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What I dont understand is that it seems that most ppl get watery semen to some extent from finasteride or dutasteride. But on 2.5mg dutasteride my semen was unchanged or even thicker hmmm.
Very weird. It never happened to me on dutasteride nor finasteride
 
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Adri23

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@Adri23
Is 25 mg bica eod enough to block my AR ? I'm still hairy on 4 mg estradiol bro wtf ?
Most likely yes. When I was taking 25 mg of bica EOD I had less hair on my body and even on my beard. Now that i stopped it for a month already, I am getting hairy again.

There is a study that shows it. https://www.jaad.org/article/S0190-9622(21)02738-9/fulltext

''All patients commenced bicalutamide at a dose of 10 mg. The mean dose of bicalutamide that reduced hypertrichosis was 14.4 mg (SD, 5.25 mg). The use of concurrent bicalutamide permitted an increase in the mean daily dose of minoxidil to 2.2 mg (SD, 1.67 mg) without development of hypertrichosis.''

''Oral bicalutamide appears to be beneficial in mitigating hypertrichosis caused by minoxidil in FPHL patients. Daily bicalutamide (mean dose, 14.4 mg) both reduced hypertrichosis and permitted an increase in the mean dosing of minoxidil by 0.7 mg/day without further hypertrichosis.''



As you can see per studies 14.4 mg is enough to reduce the hypertrichosis, so 25 mg EOD would be 100 mg a week and 14.4 mg ED is 100.8 mg a week so as you cant really take 14.4 mg the best bet is to use 25 mg EOD, which due to bica's half life it will be very similar than taking 14.4 mg ED.
 
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sg2000

Experienced Member
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Even tough it doesn seem to be guaranteed im gonna give it a try and that would be my last.At least im gonna have that peace of mind that ive tried everything i can for my hair.If after 1 year im still losing ground i will stop everything!
 
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