Exploring The Hormonal Route. Hair=life.

[Adri23]

Lmao imagine being sensitive to androgens so you want a higher shbg to make them less bioavailable but you have sh*t estradiol sensitivity and you need low shbg levels to get more free estradiol xD. Thank god bica and dutas exist. Also I think orchi will unironically benefits me a lot because I will be able to lower my levels a lot without a T rebound and get my shbg down to 60 nmol/L like in the past and boost my free e2. May have more free T and DHT but bica and dutasteride should get rid of that issue.

 

[Gergely]

I think free e2 is just something random like, yes having more free e2 should lead to better outcomes but I think it is the sensitivity what matter most. You can have shitty free estradiol yet have everything ok or have good free e2 like me and everything is sh*t. Like maybe on your case and Gergely your free e2 is not that great yet you are good because you have good sensitivity to e2. I literally need like a free e2 of 2% or more to see positive stuff. I bet my e2 receptors are kinda insensitive like I have many kind of mutations so one more wouldn't be a surprise to me . High 5ar1 and 5ar2 enzyme activity, poor aromatase, fucked up e2 receptors. Damn life wants me bald and ogre holy sh*t.

While im not going to post any pictures. When my SHBG was low 58,64 nmol/L and E2 in reasonable range of 847,0 pmol/L. Back in 2021 i had the best results regarding with things you're looking for

 

[Adri23]

While im not going to post any pictures. When my SHBG was low 58,64 nmol/L and E2 in reasonable range of 847,0 pmol/L. Back in 2021 i had the best results regarding things you're looking for

I literally had the same experience as you! That can explain a lot

 

[Adri23]

Ok, think I'll test salivary free E2 just to know how it differs from calculated one. Also gonna test for IGF-1, 3a diol-g, dhea-s. Mb any other suggestions?

That would be great. I also test igf-1 3adg, dhea-s, but also DHEA and androstenedione among other stuff to rule out adrenal issues or smthing like that

 

[Adri23]

I'm gonna be lowering my E2 progressively from 6 mg to 5 mg per week. I hope my balls are dead enough so I don't get a T rebound. I put them on an alcohol-induced coma so they better be dead

 

[Gergely]

I'm gonna be lowering my E2 progressively from 6 mg to 5 mg per week. I hope my balls are dead enough so I don't get a T rebound. I put them on an alcohol-induced coma so they better be dead

I'm on 4mg EV/week 50mg bica/day 9mg boron/day as of my last blood test

 

[Adri23]

I'm on 4mg EV/week 50mg bica/day 9mg boron/day as of my last blood test

Idk how you have high shbg with such low dosage of estradiol especially for EV weekly injections. Do you have or have had any kind of malnutrition recently? Do you have gut issues of any kind?

 

[Adri23]

I already tested 3a-Androstanediol Glucuronide, 11-deoxycortisol, 17-OHP, ACTH, DHEA, Pregnenolone, 3a-diol-g and all types of cortisole b4.
Unfortunately can't find it rn, its from 3 years ago, I think its on my old phone. Everything was in ok ranges, except ACTH, cortisole and 17-OHP pretty low, so I'll as well test at least those.

That's a great one. I still want to test 11-deoxycortisol as well but I will have to pay for it. It isn't too expensive so all ok

Everything was in ok ranges, except ACTH, cortisole and 17-OHP pretty low, so I'll as well test at least those.

Yeah those are important especially if you have any kind of issue with them. Mine are under normal range as of the last 2 blood test (6 and 3 months ago) I will get the new one on friday

 

[Gergely]

Idk how you have high shbg with such low dosage of estradiol especially for EV weekly injections. Do you have or have had any kind of malnutrition recently? Do you have gut issues of any kind?

This is not accurate. When the test was taken i was on 4mg EV every 4 days. And before that i used to abuse Diane 35 and CPA for some time

 

[Dav1234]

Metformin is also known to increase SHBG. You might want to quit that

If I have oily scalp itchy feels like inflammation will metformin help? I see people using it for pcos, and helping reduce glucose levels.

 

[Adri23]

This is not accurate. When the test was taken i was on 4mg EV every 4 days. And before that i used to abuse Diane 35 and CPA for some time

Oh so maybe you have way lower shbg then cause 4 mg/week EV is low dosage

 

[Gergely]

If I have oily scalp itchy feels like inflammation will metformin help? I see people using it for pcos, and helping reduce glucose levels.

It's possible, since SHBG primarily binds T/DHT Side note: Ketoconazole will help you more if you're not already using it

 

[Gergely]

Oh so maybe you have way lower shbg then cause 4 mg/week EV is low dosage

It'll be a couple of months till my next test. Around the end of the year. I will leave a note

 

[Adri23]

It'll be a couple of months till my next test. Around the end of the year. I will leave a note

Yeah please update, I'm interested. Again thanks for sharing your levels!

 

[foy]

I'm doing fine according to the people who see me

You're all so lucky, damn, then there's me who has the shbg and dht in the f*****g sh*t and I look like a f*****g ugly, masculinized monkey......

 

[Seanrutty]

Adding dutasteride once a week will do nothing compared with daily.

I'd say Norwood 1.5

Hey fast question as far as the back door I’m still looking into it.. if it is happening to me does it mean finasteride is useless as in is the back door pathway tons of dht or just some and I had a test done about a month ago for test dht all that stuff

 

[Adri23]

Hey fast question as far as the back door I’m still looking into it.. if it is happening to me does it mean finasteride is useless as in is the back door pathway tons of dht or just some and I had a test done about a month ago for test dht all that stuff

Depends on your genetics. There are ppl that has more active 5ar1 than others. Same with 5ar2. And yes finasteride do nothing against 5ar1

 

[Seanrutty]

Depends on your genetics. There are ppl that has more active 5ar1 than others. Same with 5ar2. And yes finasteride do nothing against 5ar1

Okay I guess my question is if I had the back door pathway finasteride won’t do anything for type one but my question is if I did nothing not finasteride at all wouldn’t it be worse??

 

[Seanrutty]

Okay I guess my question is if I had the back door pathway finasteride won’t do anything for type one but my question is if I did nothing not finasteride at all wouldn’t it be worse??

Thanks for the fast response too

 

[Seanrutty]

Thanks for the fast response too

I’ll have to look all I know is the endo said my test is like 460 and dht is like 8 I think he said ill have to find the paper.. that gene test you were talking about last night does it test for if someone has more type 1?? And if so like I said if type 1 and type 2 are both at play with me wouldn’t taking finasteride to at least help type 2 be better the doing nothing ???