Finasteride and Type 1/Type 2 5a reductase

ChiaHead

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So, ive been on the big 3 for a year now (4/20) and I've noticed some things. I have had alot of thickness in my existing hairs and had alot of dwarfed hairs grow up to be normal, terminal hairs. Now most of my regrowth was along the top of my head and the crown. But for my temples and hairline, I have noticed tons of white to semi-colored hairs growing there. Most have been this way for 4-5 months and they are just growing longer, but very very slowly.

Finasteride only binds with Type 1 5a-reductase. Knowing this, I think that alot of our frontal hairs are attacked by both type 1 and type 2 reductase as these frontal hairs seem like they are only partially effected by the finasteride. Since minoxidil is only a growth stimulator, it is just making them grow faster but not thicker or darker.

Im sure this is why avodart is "suppose" to me more effective, but I myself havent heard of any real success stories from avodart yet.
 

Rage

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There is a fundamental flaw in your argument.. it is DHT which affects your hair, not the 5alpha-reductase. Finasteride inhibits type-2, which appears in the highest concentrations in the hairline.

I think what is happening here, is that the places (temple) where you want the most "regrowth" cannot regrow much as there is already severe miniaturisation (it was one of the first places where hairloss starts) so while the hairs may come back longer/thicker, it won't be of the same quality as on the top of your head. Perhaps they will never fully recover, or just take a long time...

But congrats on your regrowth! Many people on this forum haven't come close to the success on their treatment as you have!!
 

ChiaHead

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this is quoted from the "Product reviews" part of this website under Propecia: method of action

"Testosterone floating in the bloodstream of the typical adult male routinely combines with an enzyme called 5-alpha reductase. The result of this interaction forms the more potent sexual hormone known as DHT"

Link to the rest of article:
http://www.gourmetstylewellness.com/productreviews/men/propecia/index.htm
 
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