Finasteride As A Preemptive Measure Just In Case

[abcdefg]

I think finasteride should only be taken orally if you have a life threatening condition. Look at the finasteride paper I referenced to in the earlier post and count the number of times the words "persistent, irreversible and permanent" appear in the paper. The drug is potent down to 0.05mg oral, that has been documented. And taking 0.2mg has the same effect as taking 1mg. We know the drug lowers DHT to castration levels, we know it causes sexual and mental problems. All documented and proven as statistically significant.

It doesnt lower DHT to castration levels. I do think the neurosteroids and the central nervous system is why finasteride causes the sexual side effects that it does. Really in a perfect world they would reformulate finasteride to not inhibit 5 ar 3 or any neurosteroids. Just target DHT some other way or through a different enzyme or part of this path. We know they wont though its too expensive.
Finasteride isnt perfect, but its the best we have. It cant be too dangerous for most men 20 years out because we have tons of men right now meeting those conditions.

 

[Endmymisery]

It doesnt lower DHT to castration levels. I do think the neurosteroids and the central nervous system is why finasteride causes the sexual side effects that it does. Really in a perfect world they would reformulate finasteride to not inhibit 5 ar 3 or any neurosteroids. Just target DHT some other way or through a different enzyme or part of this path. We know they wont though its too expensive.
Finasteride isnt perfect, but its the best we have. It cant be too dangerous for most men 20 years out because we have tons of men right now meeting those conditions.

finasteride sides could also be attributed to the raise in estrogen imo

 

[abcdefg]

finasteride sides could also be attributed to the raise in estrogen imo

Could. A lot of parts of this study talk about dutasteride and not finasteride. There are some pretty significant differences between the two drugs. Id look at studies like this as more just future directions of research, and possible methods of action. I still think taking finasteride is your best bet if your going bald. I dont know of any other better way yet do you?

 

[hairfertilizer]

I dont know of any other better way yet do you?

Very low dose topical. Even using 0.01mg topical is having systematic effects. That is the dose of a regular finasteride pill split into 100 and wiped on your head. That is how crazy this drug is. So realistic options are extreme low dose topical, shave, or toupee. Based on the literature, I would not use oral finasteride and wouldn't recommend others to use it. Especially at the prescribed 1mg dosage, where 0.2mg achieves the same result.

 

[hairfertilizer]

finasteride sides could also be attributed to the raise in estrogen imo

It's the DHT blockage that is causing the problem. You need DHT for a lot bodily functions, you can't just wipe it out and not expect things to go wrong.

The steroid products of the 5α-Rs pathways undergo further metabolism by the 3α-hydroxy-steroid dehydrogenase (3α-HSD) to produce a host of active neurosteroids with important physiological function, in many tissues including the central nervous system (CNS)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064044/