If I'm correct about this then vitamin D3 could be acting like an anticancer agent which Aubrey De Grey said senescent cells should be treated like cancer to remove them. Senescent cells are like cancer and tough to get to go thru apoptosis.
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Yes, Aubrey De Grey has said that senescent cells should be treated like cancer. De Grey is an anti-aging researcher who believes that senescent cells are a key part of the aging process and that treating them could help prevent disease and extend life.
The diclofenac study proved to me that the success of the older gentlemen was a clearing of senescent cells. Problem is we don't want to damage healthy cells trying to clear out senescent ones in the process.
There is a solution. If I'm correct then vitamin d3 will be synergistic with nicotinamide a known PARP-1 inhibitor.
In this communication we discuss a novel therapeutic paradigm of supplementation of Vitamin D with PARP inhibitors, the effect on which in tandem could produce a very selective mechanism of killing of malignant cells (that spares normal cells). We also discuss clinical implications of this observation and the possibility of its development as a support strategy for chemotherapy.
Vitamin D has a known, well demonstrated potential for killing malignant cells, by both genomic and non-genomic mechanisms [26]. One of the non-genomic mechanisms of the chemotherapeutic effect of vitamin D is its interaction with elevated copper within malignant cells.
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Yes, Aubrey De Grey has said that senescent cells should be treated like cancer. De Grey is an anti-aging researcher who believes that senescent cells are a key part of the aging process and that treating them could help prevent disease and extend life.
The diclofenac study proved to me that the success of the older gentlemen was a clearing of senescent cells. Problem is we don't want to damage healthy cells trying to clear out senescent ones in the process.
There is a solution. If I'm correct then vitamin d3 will be synergistic with nicotinamide a known PARP-1 inhibitor.
In this communication we discuss a novel therapeutic paradigm of supplementation of Vitamin D with PARP inhibitors, the effect on which in tandem could produce a very selective mechanism of killing of malignant cells (that spares normal cells). We also discuss clinical implications of this observation and the possibility of its development as a support strategy for chemotherapy.
Vitamin D has a known, well demonstrated potential for killing malignant cells, by both genomic and non-genomic mechanisms [26]. One of the non-genomic mechanisms of the chemotherapeutic effect of vitamin D is its interaction with elevated copper within malignant cells.