Gene Therapy - Fixing Single Nucleotide Polymorphisms to cure PGD2 sensitivity

[Armando Jose]

You should make your own lab man, most of these pathways are linked to cancer and one of them is linked to prostate cancer and autoimmune diseases
does increasing everyone of them individually will make a better regrowth?

Is not that the same reason we lose hair when it comes to cancer with chemo? Hair is one of the structures of highest cell growth in our body.

 

[Nadia1972]

the important DHT for hair is made in itself parting from cholesterol, castration don't stop the production of DHT in scalp hairs.

However,androcur and provames have made me grow full of hair and increase my cholesterol

 

[Armando Jose]

However,androcur and provames have made me grow full of hair and increase my cholesterol

Hi

Not by having high cholesterol level you will have more production of sebum. I do not understand what you mean by the increase in cholesterol.

On the other hand, what kind of alopecia did you have? Localized or diffuse?

 

[Nadia1972]

Hi

Not by having high cholesterol level you will have more production of sebum. I do not understand what you mean by the increase in cholesterol.

On the other hand, what kind of alopecia did you have? Localized or diffuse?

My alopecia is androgenetic totally and completely.The hormones work very well for me.I'm a women .Our alopecia is always diffuse
I mean I have such lipid in the blood that my serum is trouble. All this because of the hormones because it never happened to me

 

[Armando Jose]

Cholesterol is vital for our life, no cholesterol and we are dead.

 

[Nadia1972]

Cholesterol is vital for our life, no cholesterol and we are dead.

i learned that cholesterol would protect against breast cancer according to a study. Statins that lower cholesterol levels are carcinogenic

 

[InBeforeTheCure]

do you know if reducing that hormone itself would be beneficial? i read it's involved in stress response so could there be any truth in stress being bad for hair?

I was wondering the same thing. Heath et al. estimate that M.P.B. is 77-85% heritable*, so there's room for environmental factors to play a role. Maybe CRH levels could account for some of the 15-23% non-heritable part of M.P.B.?

* Variance in when you start to lose hair and how fast you lose it could account for much of the non-heritable part of M.P.B, rather than whether you ever lose it.

BTW, CRH is also produced in the skin. Notice that something like UVB can also stimulate its production. Could reducing it be beneficial? Possibly in some cases. Maybe better would be to target the downstream pathway most relevant to M.P.B which, based on other associated genes**, would probably be the intracellular calcium pathway ending in activation of AP-1 -- this is involved in keratinocyte differentiation and proliferation.

**Besides CRHR1, some other M.P.B.-associate genes are: FYN, PIK3R1 (the p85 subunit of PI3K), PLCG1 (PLC-gamma1), ITPR2 (one of the IP3 receptors), PRKCA (PKC-alpha), and FOSL2. These are all known components of the calcium-induced keratinocyte differentiation pathway, some of which are shown in the CRH diagram.

Also, estrogen reduces expression of FOS, GJA1, IL6, and KRT1 while increasing expression of KRT14 -- all consistent with reduced activity of the CRH pathway, especially the parts that act through c-Fos/AP-1.

You should make your own lab man, most of these pathways are linked to cancer and one of them is linked to prostate cancer and autoimmune diseases
does increasing everyone of them individually will make a better regrowth?

All those things I mentioned are probably beneficial, except maybe the intracellular calcium...?

 

[bridgeburn]

I was wondering the same thing. Heath et al. estimate that M.P.B. is 77-85% heritable*, so there's room for environmental factors to play a role. Maybe CRH levels could account for some of the 15-23% non-heritable part of M.P.B.?

* Variance in when you start to lose hair and how fast you lose it could account for much of the non-heritable part of M.P.B, rather than whether you ever lose it.

BTW, CRH is also produced in the skin. Notice that something like UVB can also stimulate its production. Could reducing it be beneficial? Possibly in some cases. Maybe better would be to target the downstream pathway most relevant to M.P.B which, based on other associated genes**, would probably be the intracellular calcium pathway ending in activation of AP-1 -- this is involved in keratinocyte differentiation and proliferation.

**Besides CRHR1, some other M.P.B.-associate genes are: FYN, PIK3R1 (the p85 subunit of PI3K), PLCG1 (PLC-gamma1), ITPR2 (one of the IP3 receptors), PRKCA (PKC-alpha), and FOSL2. These are all known components of the calcium-induced keratinocyte differentiation pathway, some of which are shown in the CRH diagram.

Also, estrogen reduces expression of FOS, GJA1, IL6, and KRT1 while increasing expression of KRT14 -- all consistent with reduced activity of the CRH pathway, especially the parts that act through c-Fos/AP-1.



All those things I mentioned are probably beneficial, except maybe the intracellular calcium...?

Thanks for the extremely scientific reply. I'm trying to understand it the best I can. hahaha. So, about UVB light, I've been often going outside in the heat of the day and exposing my temples to sunlight for a few minutes a day because I've read that UVB stimulates PGE2 and that when researches added Vitamin D to stem cells it coaxed them into becoming follicles. I figured getting a little sunshine on the scalp may help and probly wouldn't hurt, now im a bit worried if it increases CRH.

This chart is pretty overwhelming and seems to contain many negatives for hair.
Is there anything beneficial on it?
Also, this may sound like a very ignorant question, but Calcium pathway? like the Calcium that makes bones stronger? oh sh*t, I literally had just finished drinking a glass of milk before reading your reply! yeah, i know I'm paranoid. lol

 

[Balding curse]

All those things I mentioned are probably beneficial, except maybe the intracellular calcium...?

Sorry you got me wrong, I mean you are knowledgeable about genes and science,
what I found changes on these pathways like mutation or overexpress could develop cancer.
I'm not into gense science, I just found that on a quick read, my question is can we increase every pathway individually to get a better result?

 

[InBeforeTheCure]

This chart is pretty overwhelming and seems to contain many negatives for hair.
Is there anything beneficial on it?

Yes, definitely. CTNNB1 (beta-catenin) is one example. A total loss of intracellular calcium signaling would also be disastrous.

Also, this may sound like a very ignorant question, but Calcium pathway? like the Calcium that makes bones stronger? oh sh*t, I literally had just finished drinking a glass of milk before reading your reply! yeah, i know I'm paranoid. lol

https://en.wikipedia.org/wiki/Calcium_signaling

Don't know whether dietary calcium would have much effect.

Sorry you got me wrong, I mean you are knowledgeable about genes and science,
what I found changes on these pathways like mutation or overexpress could develop cancer.
I'm not into gense science, I just found that on a quick read, my question is can we increase every pathway individually to get a better result?

For each particular pathway, you would need to do experiments to find out -- otherwise you don't know whether you've hit a plateau. For an AR inhibitor, you can certainly do much better with something like enzalutamide. To activate beta-catenin, a combination of Wnt + R-spondin would probably be much stronger. Others I'm not sure of.

(And I'm not saying those things are necessarily safe, BTW )