Going to start topical dutasteride. ADVICE NEEDED

[youngndumb]

i remember awhile back College posted about mixing dutasteride with minoxidil, and it seemed, scientifically, it made sence. i just received an order of DUPROST. i really cannot afford to take the dutasteride. orally on a daily basis, so i would like to give the dutasteride. in minoxidil idea a try. if i remember correctly, college said to squirt 2-4 capsules od dutasteride. into a bottle of minoxidil and this should, in theory, work as well as injesting the drug internally. before i try this, can anyone verify that this may work, any downside to it, or if anyone has tried it with results. feedback appreciated

 

[youngndumb]

anyone??

 

[arrogantprick]

I have sucess with it topically with great results, but I use it orally as well as using other some other things, so I cannot single that out. Check out my post in the success stories forum for pics.

What may be more cost effective is using 4 caps in minoxidil, but getting a generic finasteride to use orally and cut into very small dosages (maybe 1/5 gram).

 

[CCS]

lots of desperate people keep quoting me on my oldest posts. I know longer think it is that simple.

It may be possible to make it happen, but you need something like oleic acid to make it stay wet longer, and you need octyl salicylate to increase penetration, and you need to take off after 3 hours, and you need to use the right dose. I don't know what the right dose is. I don't even know if the dutasteride will enter the follicle at all, or go straight into back to the heart. That is a skin biology question.

You see, it enters the pores, and I don't know where it goes next. If it goes into the sebum glands next, it may exit them through the veins, which to straight back to the heart, unless the blood vessels up there are differnet.

Minoxidil is a good base since it penetrates blood vessel walls and might help dutasteride take other routes. But if you do the stuff topically, there is a good chance you won't get enough, and will be balder in 6 months. Many guys doing it orally get sheds, and think they should stay on it. What will you do when you get a shed?

Also, the topical dutasteride only works where you apply it. The rest of the head will thin. The minoxidil costs $7 per month. Why not spend $13.5 and do dutas every third day?

 

[Old Baldy]

College: I agree with the vast majority of what you said. However, some of the dutasteride. will get into our systems IMHO. People need to know that.

You can limit the amount getting into your system, as you know and probably have some local effect also? But some of the stuff will get into our systems IMHO. Same for finasteride.

So if someone wants NO finasteride. and/or dutasteride. in their systems, the topical route is unsatisfactory IMHO.

Btw, octyl salicylate has fatty alcohol in it. It has a very similar texture to oleic acid. It will keep your scalp slightly "wet" with as little as 5 percent. If you go up to 10 percent, the stuff stays too wet IMHO.

If it were me I would add 2.5 percent oleic acid with 2.5 percent octyl salicylate acid to give you a total of 5 percent. I just use the octyl salicylate acid now but I'm sure I'll go back to using oleic acid as the new found "fun" of using octyl salicylate wears off in my wacko brain.

Do you and Bryan still think oleic acid from the chemistry store has an anti-androgen effect? I'm just not in agreement with you guys on that one. Just a gut level feeling. Not pure enough, etc.?

 

[CCS]

you mis understood me.

I said that ALL of the dutasteride absorbed through the skin will get into our system.

The issue here is blood concentration and follicle concentration. You need to add only enough to keep the follicle concentration at a therapudic level for the amount of time it takes to complex with 5ar2. Obviously higher concentrations complex faster, and we have a minimization problem and must know what DHT levels are therapudic enough.

All this dutasteride will go systemic, though some may be bond to 5ar2 when it leaves. Since it will be diluted, it may have a low enough concentration to not have noticeable systemic effects.

For this to work, a large enough percentage of the topical dutasteride must go to the follicle before going to the heart, and the therapudic levels of dutasteride in the follicle must be low enough and the levels that affect the body must be high enough.

This takes lab research. My suggestions will increase people's chances of getting something that works, but there are no guarantees. And if it does not work, you will know when you loose you hair in 6 months.

Guys with side effects can know how much is entering the blood, but they don't know the concentration in the follicles and if there is a therapudic effect.

 

[Old Baldy]

Sorry College, I misunderstood.