hey tranzept
GTE (Green Tea Extract) and GSE (Grape Extract) are effective antioxidants, and may have some hairloss benefits too. Topical GTE is excellent for reducing scalp irritation and inflammation.
Here are a couple of interesting extracts to give you a heads-up
(Green Tea) - Mechanisms of cancer and hairloss prevention by tea polyphenols based on inhibition of TNF-alpha expression. Suganuma M, Sueoka E, Sueoka N, Okabe S, Fujiki H. - Saitama Cancer Center Research Institute, Japan.
Of greatest interest to those with androgenetic alopecia is evidence that green tea can influence serum concentrations of hormones and inhibit TNF-a. Research in this area is primarily with reference to hormonal effects on the development of cancer and how green tea and other caffeine containing products might mediate changes in hormone levels.
For example, high intake of green tea has been associated with higher levels of sex hormone binding globulin (SBHG) and lowered levels of serum estradiol (estrogen) concentration in women (Nagata 1998). Increased SBHG may be of help in reducing the effects of androgenetic alopecia. SBHG is a molecule that binds with high affinity to testosterone. Testosterone bound to SBHG is not bioactive and cannot bind to androgen receptors or be converted into dihydrotestosterone.
An increase in SBHG concentration effectively reduces free testosterone. green tea may also have an affect on the type I 5 alpha reductase enzyme that converts testosterone to dihydrotestosterone. These two distinct, but complementary, effects of green tea may influence androgenetic alopecia.
One cup of green tea roughly equals 50 mg of tea catechins. Typically research investigations have involved individuals drinking six cups of green tea, or utilizing green Tea Extracts (300mg or more catechins) each day. green tea is well tolerated by most individuals with no significant side effects reported.
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(Grape Seed) - Procyanidin oligomers selectively and intensively promote proliferation of mouse hair epithelial cells in vitro and activate hair follicle growth in vivo. J Invest Dermatol 1999 Mar;112(3):310-6 Takahashi T, Kamiya T, Hasegawa A, Yokoo Y. (Tsukuba Research Laboratories, Kyowa Hakko Kogyo, Ibaraki, Japan.)
We have previously reported that proanthocyanidins extracted from grape seeds possess growth-promoting activity toward murine hair epithelial cells in vitro and stimulate anagen induction in hair cycle progression in vivo. This report constitutes a comparison of the growth-promoting activity of procyanidin oligomers and the target cells of procyanidins in the skin.
Results show that procyanidin dimer and trimer exhibit higher growth-promoting activity than the monomer. The maximum growth-promoting activity for hair epithelial cells with procyanidin B-2, an epicatechin dimer, reached about 300% (30 microM) relative to controls (= 100%) in a 5 d culture. Optimum concentration of procyanidin C-1, an epicatechin trimer, was lower than that of procyanidin B-2; the maximum growth-promoting activity of procyanidin C-1 was about 220% (3 microM). No other flavonoid compounds examined exhibit higher proliferative activities than the procyanidins.
In skin constituent cells, only epithelial cells such as hair keratinocytes or epidermal keratinocytes respond to procyanidin oligomers. Topical application of 1% procyanidin oligomers on shaven C3H mice in the telogen phase led to significant hair regeneration [procyanidin B-2, 69.6% +/- 21.8% (mean +/- SD); procyanidin B-3, 80.9% +/- 13.0%; procyanidin C-1, 78.3% +/- 7.6%] on the basis of the shaven area; application of vehicle only led to regeneration of 41.7% (SD = 16.3%).
In this paper, we demonstrate the hair-growing activity of procyanidin oligomers both in vitro and in vivo, and their potential for use as agents to induce hair growth.