Hair loss renewing after 5 years on AvoDart

[abcdefg]

Can someone explain to me how inhibiting that amount of dht using something like dutasteride does not stop male pattern baldness? I mean clearly dht is far from the sole cause of male pattern baldness. How can dutasteride stop hairloss for one person and not stop it for another?

 

[Dogs3]

apparently in spite of how much dht dutasteride inhibits (something like 95% or so), the hair follicles will keep becoming more and more sensitive to dht over time, so the 5% thats left over will be enough to continue the male pattern baldness process over enough time. Plus there are probably more factors with genetics but im not sure about any of that.

 

[dresden]

i cant imagine how 5% of normal DHT levels will do that much damage to a lot of people who are still losing hair on dutasteride. there must be another reason besides the damaging effect of DHT

 

[Hammy070]

i cant imagine how 5% of normal DHT levels will do that much damage to a lot of people who are still losing hair on dutasteride. there must be another reason besides the damaging effect of DHT

Dutasteride inhibits over 90% of serum DHT.

Scalp DHT is another issue. Dutasteride inhibits just over half of scalp DHT (where it matters most), and finasteride around a third. When you look at those numbers it's quite clear why hairloss resumes later on, 50% of the DHT is still present in the scalp even on Avodart. But again, there is a unique DHT:SENSITIVTY ratio for all of us, basically how much heat you can handle before you burn.

This ratio can really only be assessed with trial and error. There are also other variables, responsiveness, immune and digestive systems, how your endochrinal system readjusts (ie. do DHT receptors increase/decrease? If so by how much? etc). It's not the drugs themselves we don't understand, we lack crucial data on our own biology to determine what would be effective, and to what degree. Generalized medicine is a thing of the past. There needs to be some kind of service or clinic that analyzes as much data as possible, genetic, cellular etc. might cost a lot, perhaps $1k but how much will you save you in the long-term if you have precise treatments tailored to yourself, instead of costly trial and error regimes which need to be tried out for around a whole year just to see if it works. Hairloss treatments are excellent for business, whatever the results it works! Loss = shedding No results = maintenance and regrowth = actual results. I notice my brothers who are bald NW4, they havn't really changed at all in 10 years, they don't use any treatments. If they used X product, they would have attributed their "maintenance" to that.

So much uncertainty because of lack of data which is silly in this age. In few other fields is trial and error used as much, nobody builds a foundation of a building or serves a gourmet dish merely hoping that it works, lots of rigorous testing.

 

[el_duterino]

Testosterone is the other factor. dutasteride raises it to about 120%. You need to protect your hair from the effect of DHT but also test if you want to halt hairloss.

That's why anti-androgens such as RU58841 or Flutamide are so effective, blocking DHT 1&2 and test from binding to the AR.

 

[Timi]

el_duterino

have you become New Hair with Fluta?


Timi

 

[TwoHairsLeft]

Hey dude, quick question:

I've been on Avodart for about 5 months now and the only side effects I have are my nips seem a little more sensitive and I can feel a very small formation behind my nipples as if gyno (Man tits!!!) are starting. Right now it's not really noticeable aesthetically but I was wondering if you had the same thing (small clumps behind nipples). If it just stays like it is now I'm fine, if it gets worse (larger) then I'll probably go back to finasteride.

thanks man! Have a good week

NOTE: this was an accidental bump, I meant to PM this guy and hit reply instead--oops

Hi All,

I used to be an active member of these forums back in 2001 - 2002. During that time I was using Propecia and Minoxodil and had slowed my hair loss. I was around 21-22 years old at the time and certainly not enjoying seeing 50-100 hairs in my hands as I washed my hair. I was in college and although the hair loss was not visible to others (very thick hair, you see) - it definitely ruined my self esteem.

Then I found AvoDart; I had followed its progress closely and when I found out I could get a prescription for .5mg off label, I did just that.

I can honestly say that for the rest of college and into the first 5 years of my professional, post-college life - I noticed zero hair loss. My hair was thick and full and I could brush and wash my hair all day and hardly notice but a few hairs. I did notice during this time, however, significant loss of color pigment in my hair and a few other side effects which I won't go into great detail. :shakehead:

Over the past three months I have been hit by what I can either describe as shedding (positive outlook) or the renewal of my hair loss from my college days (realistic outlook). My scalp and hair seem very much as they were in college; a lot of itchiness, rough hair, and some thinning in the frontal portion of my head. When I take a shower I notice the all-too familiar 20-30 hairs lost.

What should I do? Stick it out on AvoDart? I've read that some people are combining Propecia and AvoDart and having success. Can anyone recommend this regimen? I have bumped up my AvoDart intake to include one day a week where I take two .5mg pills. I'm wary of taking two every day. Many on this board seem to think AvoDart is still an experimental and ill-advised treatment.

Is there any sound evidence that medications like AvoDart decrease in effectiveness over time? Is my body becoming immune or maybe the DHT levels are now greater than they were 2-3 years ago?

Ultimately I will have to cease AvoDart at some point. I don't want to take any chances with starting a family; you can't donate blood while on AvoDart and women are encouraged to not even touch the stuff. So clearly it must not be good for trying to have a child. Has anyone read any further studies on this, by the way?

Your thoughts are welcome.

Thanks.